CCL20 chemokine induces both osteoblast proliferation and osteoclast differentiation: Increased levels of CCL20 are expressed in subchondral bone tissue of rheumatoid arthritis patients

2006 ◽  
Vol 210 (3) ◽  
pp. 798-806 ◽  
Author(s):  
Gina Lisignoli ◽  
Anna Piacentini ◽  
Sandra Cristino ◽  
Francesco Grassi ◽  
Carola Cavallo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Tissue ◽  
Subchondral Bone ◽  
Osteoclast Differentiation ◽  
Osteoblast Proliferation ◽  
Subchondral Bone Tissue

Metabolism of subchondral bone tissue in posttraumatic osteoarthrosis in rats

2021 ◽  
Vol 172 (8) ◽  
pp. 240-243
Author(s):  
R. А. Zubavlenko ◽  
◽  
S. V. Belova ◽  
V. Yu. Ul'yanov ◽  
◽  
...  
Keyword(s):  
Bone Tissue ◽  
Subchondral Bone ◽  
Posttraumatic Osteoarthrosis ◽  
Subchondral Bone Tissue

The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass

2018 ◽  
Vol 69 (9) ◽  
pp. 2541-2545
Author(s):  
Raluca Barzoi ◽  
Elena Rezus ◽  
Codruta Badescu ◽  
Razan Al Namat ◽  
Manuela Ciocoiu
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Cells ◽  
Osteoclast Differentiation ◽  
Bone Destruction ◽  
Nuclear Factor ◽  
Receptor Activator ◽  
Level Function ◽  
Rheumatoid Polyarthritis ◽  
The Impact ◽  
Nuclear Factor Kb

There is a bidirectional interaction between most immune cells and osteoblasts, osteoclasts and their precursor cells. The receptor activator of nuclear factor-kB ligand (RANKL)/RANK/osteoprotegerin (OPG) system plays an essential role in the formation of osteoblasts, but it also has implications in osteoclast biology and implicitly on the diseases characterized by bone loss. Proinflammatory cytokines existing at synovial level function as direct or indirect stimulators of osteoclast differentiation, but also of its survival or activity, although some cytokines may also play an antiosteocastogenic role. The fate of bone destruction is determined by the balance between osteoclastogenic and antiosteoclastogenic mediators. Our study has shown that the early initiation of the therapy with anti-TNF and anti-IL6 biological agents, in patients with rheumatoid arthritis, inhibits bone destruction, regardless of the anti-inflammatory activity in patients with rheumatoid arthritis.

Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair

Life Sciences ◽  
2003 ◽  
Vol 73 (15) ◽  
pp. 1973-1983 ◽  
Author(s):  
Stefano Guizzardi ◽  
Carlo Galli ◽  
Paolo Govoni ◽  
Renata Boratto ◽  
Giulia Cattarini ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Repair ◽  
Human Osteoblast ◽  
Osteoblast Proliferation
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