An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition

2006 ◽  
Vol 209 (3) ◽  
pp. 706-710 ◽  
Author(s):  
Gary S. Stein ◽  
André J. van Wijnen ◽  
Janet L. Stein ◽  
Jane B. Lian ◽  
Martin Montecino ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Control ◽  
S Phase ◽  
Phase Cell ◽  
Cell Cycle Transition ◽  
Architectural Perspective

scholarly journals Downregulation of ZBTB24 hampers the G0/1- to S-phase cell-cycle transition via upregulating the expression of IRF-4 in human B cells

2016 ◽  
Vol 17 (5) ◽  
pp. 276-282 ◽  
Author(s):  
J Liang ◽  
R Yan ◽  
G Chen ◽  
J Feng ◽  
W-W Wu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
B Cells ◽  
S Phase ◽  
Phase Cell ◽  
Human B Cells ◽  
Cell Cycle Transition

scholarly journals The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

2008 ◽  
Vol 9 (8) ◽  
pp. R127 ◽  
Author(s):  
Nicole Cloonan ◽  
Mellissa K Brown ◽  
Anita L Steptoe ◽  
Shivangi Wani ◽  
Wei Chan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
S Phase ◽  
Phase Cell ◽  
Cell Cycle Transition

Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma

2013 ◽  
Vol 223 (1) ◽  
pp. 60-72 ◽  
Author(s):  
Subramanian Raghunandhakumar ◽  
Arumugam Paramasivam ◽  
Selvam Senthilraja ◽  
Chandrasekar Naveenkumar ◽  
Selvamani Asokkumar ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
S Phase ◽  
Phase Cell ◽  
Cell Cycle Transition

scholarly journals A General G1/S-Phase Cell-Cycle Control Module in the Flowering Plant Arabidopsis thaliana

PLoS Genetics ◽  
2012 ◽  
Vol 8 (8) ◽  
pp. e1002847 ◽  
Author(s):  
Xin'Ai Zhao ◽  
Hirofumi Harashima ◽  
Nico Dissmeyer ◽  
Stefan Pusch ◽  
Annika K. Weimer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Arabidopsis Thaliana ◽  
Cell Cycle Control ◽  
S Phase ◽  
Flowering Plant ◽  
Phase Cell ◽  
Control Module ◽  
Plant Arabidopsis Thaliana

Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells

2012 ◽  
Vol 33 (12) ◽  
pp. 1500-1505 ◽  
Author(s):  
Yu Sun ◽  
Shusheng Tang ◽  
Xi Jin ◽  
Chaoming Zhang ◽  
Wenxia Zhao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
S Phase ◽  
Mapk Signaling Pathway ◽  
Phase Cell ◽  
Human Hepatoma ◽  
Cycle Arrest

scholarly journals S-Phase Cell Cycle Arrest, Apoptosis, and Molecular Mechanisms of Aplasia Ras homolog Member I–Induced Human Ovarian Cancer SKOV3 Cell Lines

2014 ◽  
Vol 24 (4) ◽  
pp. 629-634 ◽  
Author(s):  
Qiaoying Zhu ◽  
Jianming Hu ◽  
Huijuan Meng ◽  
Yufei Shen ◽  
Jinhua Zhou ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Molecular Mechanisms ◽  
Significant Inhibition ◽  
S Phase ◽  
Phase Cell ◽  
Cell Cycle Distribution ◽  
Human Ovarian Cancer ◽  
Skov3 Cell ◽  
Skov3 Cells

ObjectiveAplasia Ras homolog member I (ARHI) is associated with human ovarian cancer (HOC) growth and proliferation; however, the mechanisms are unclear. The purpose of this study was to investigateARHIeffects in HOC SKOV3 cells.MethodsWe transfected SKOV3 cells with PIRES2-EGFP-ARHI and measured growth inhibition rates, cell cycle distribution, apoptosis rates, and expression of P-STAT3 (phosphorylated signal transduction and activators of transcription 3) and P-ERK (phosphorylated extracellular signal regulated protein kinase).ResultsOur data showed significant inhibition of growth, significantly increased S-phase arrest and apoptosis rates, and reduction of P-STAT3 and P-ERK1/2 expression levels.ConclusionsWe propose the mechanism may involveARHI-induced phosphorylation of ERK1/2 and STAT3 protein kinases, thereby blocking proliferation signaling pathways, to induce HOC SKOV3 apoptosis.

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