Bridging behavior and physiology: Ion-channel perspective on mushroom body-dependent olfactory learning and memory inDrosophila

2006 ◽  
Vol 209 (3) ◽  
pp. 1046-1053 ◽  
Author(s):  
Gabriel Gasque ◽  
Pedro Labarca ◽  
Ricardo Delgado ◽  
Alberto Darszon
Keyword(s):  
Ion Channel ◽  
Learning And Memory ◽  
Mushroom Body ◽  
Olfactory Learning

scholarly journals Roles for Drosophila mushroom body neurons in olfactory learning and memory

2006 ◽  
Vol 13 (5) ◽  
pp. 659-668 ◽  
Author(s):  
D.-B. G. Akalal ◽  
C. F. Wilson ◽  
L. Zong ◽  
N. K. Tanaka ◽  
K. Ito ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Mushroom Body ◽  
Olfactory Learning

scholarly journals The neuronal architecture of the mushroom body provides a logic for associative learning

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Yoshinori Aso ◽  
Daisuke Hattori ◽  
Yang Yu ◽  
Rebecca M Johnston ◽  
Nirmala A Iyer ◽  
...  
Keyword(s):  
Associative Learning ◽  
Learning And Memory ◽  
Mushroom Body ◽  
Dopaminergic Neuron ◽  
Olfactory Learning ◽  
Kenyon Cell ◽  
Feedforward Network ◽  
Kenyon Cells ◽  
Functional Logic ◽  
Dendritic Arbors

We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell–MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.

scholarly journals Reward signaling in a recurrent circuit of dopaminergic neurons and Kenyon cells

2018 ◽  
Author(s):  
Radostina Lyutova ◽  
Maximilian Pfeuffer ◽  
Dennis Segebarth ◽  
Jens Habenstein ◽  
Mareike Selcho ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Dopaminergic Neurons ◽  
Mushroom Body ◽  
Olfactory Learning ◽  
Mushroom Bodies ◽  
Neuronal Circuitry ◽  
Sustained Activity ◽  
Kenyon Cells ◽  
Reward Information ◽  
The Brain

1.AbstractDopaminergic neurons in the brain of theDrosophilalarva play a key role in mediating reward information to the mushroom bodies during appetitive olfactory learning and memory. Using optogenetic activation of Kenyon cells we provide evidence that a functional recurrent signaling loop exists between Kenyon cells and dopaminergic neurons of the primary protocerebral anterior (pPAM) cluster. An optogenetic activation of Kenyon cells paired with an odor is sufficient to induce appetitive memory, while a simultaneous impairment of the dopaminergic pPAM neurons abolishes memory expression. Thus, dopaminergic pPAM neurons mediate reward information to the Kenyon cells, but in turn receive feedback from Kenyon cells. We further show that the activation of recurrent signaling routes within mushroom body circuitry increases the persistence of an odor-sugar memory. Our results suggest that sustained activity in a neuronal circuitry is a conserved mechanism in insects and vertebrates to consolidate memories.

scholarly journals Predictive olfactory learning in Drosophila

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chang Zhao ◽  
Yves F. Widmer ◽  
Sören Diegelmann ◽  
Mihai A. Petrovici ◽  
Simon G. Sprecher ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Dopaminergic Neurons ◽  
Mushroom Body ◽  
Trace Conditioning ◽  
Fruit Fly ◽  
Olfactory Learning ◽  
Shock Strength ◽  
Behavioral Experiments ◽  
Kenyon Cells ◽  
Output Neurons

AbstractOlfactory learning and conditioning in the fruit fly is typically modelled by correlation-based associative synaptic plasticity. It was shown that the conditioning of an odor-evoked response by a shock depends on the connections from Kenyon cells (KC) to mushroom body output neurons (MBONs). Although on the behavioral level conditioning is recognized to be predictive, it remains unclear how MBONs form predictions of aversive or appetitive values (valences) of odors on the circuit level. We present behavioral experiments that are not well explained by associative plasticity between conditioned and unconditioned stimuli, and we suggest two alternative models for how predictions can be formed. In error-driven predictive plasticity, dopaminergic neurons (DANs) represent the error between the predictive odor value and the shock strength. In target-driven predictive plasticity, the DANs represent the target for the predictive MBON activity. Predictive plasticity in KC-to-MBON synapses can also explain trace-conditioning, the valence-dependent sign switch in plasticity, and the observed novelty-familiarity representation. The model offers a framework to dissect MBON circuits and interpret DAN activity during olfactory learning.

Distributed Plasticity for Olfactory Learning and Memory in the Honey Bee Brain

2011 ◽  
pp. 393-408 ◽  
Author(s):  
Brian H. Smith ◽  
Ramón Huerta ◽  
Maxim Bazhenov ◽  
Irina Sinakevitch
Keyword(s):  
Learning And Memory ◽  
Honey Bee ◽  
Olfactory Learning

scholarly journals Conditional Rescue of Olfactory Learning and Memory Defects in Mutants of the 14-3-3ζ Geneleonardo

2001 ◽  
Vol 21 (21) ◽  
pp. 8417-8425 ◽  
Author(s):  
Nisha Philip ◽  
Summer F. Acevedo ◽  
Efthimios M. C. Skoulakis
Keyword(s):  
Learning And Memory ◽  
Olfactory Learning

Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice

2013 ◽  
Vol 441 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Maruf Mohammad Akbor ◽  
Koji Tomobe ◽  
Tomomi Yamada ◽  
Juhyon Kim ◽  
Hiroki Mano ◽  
...  
Keyword(s):  
Ion Channel ◽  
Learning And Memory ◽  
Memory Dysfunction ◽  
Samp8 Mice
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