Increases in intracellular calcium dephosphorylate histone H3 at serine 10 in human hepatoma cells: Potential role of protein phosphatase 2A-protein kinase CβII complex

2005 ◽  
Vol 205 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Wei Huang ◽  
Sanjay Batra ◽  
Brett A. Atkins ◽  
Vachaspati Mishra ◽  
Kamal D. Mehta
Keyword(s):  
Protein Kinase ◽  
Intracellular Calcium ◽  
Protein Phosphatase ◽  
Potential Role ◽  
Protein Phosphatase 2A ◽  
Histone H3 ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Phosphatase 2A

Inhibition of 5‐HT1Areceptor‐dependent cell survival by cAMP/protein kinase A: Role of protein phosphatase 2A and Bax

2008 ◽  
Vol 86 (10) ◽  
pp. 2326-2338 ◽  
Author(s):  
Shu‐chi Hsiung ◽  
Adrianne Tin ◽  
Hadassah Tamir ◽  
Thomas F. Franke ◽  
Kuo‐peing Liu
Keyword(s):  
Protein Kinase ◽  
Cell Survival ◽  
Protein Kinase A ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Phosphatase 2A ◽  
Dependent Cell ◽  
Kinase A

scholarly journals Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56  subunit

2007 ◽  
Vol 104 (8) ◽  
pp. 2979-2984 ◽  
Author(s):  
J.-H. Ahn ◽  
T. McAvoy ◽  
S. V. Rakhilin ◽  
A. Nishi ◽  
P. Greengard ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Phosphatase 2A ◽  
Kinase A

scholarly journals The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets

2020 ◽  
Vol 21 (23) ◽  
pp. 8939
Author(s):  
Stephanie Makhoul ◽  
Elena Kumm ◽  
Pengyu Zhang ◽  
Ulrich Walter ◽  
Kerstin Jurk
Keyword(s):  
Protein Kinase ◽  
Platelet Activation ◽  
Protein Phosphatase ◽  
Feedback Inhibition ◽  
Protein Phosphatase 2A ◽  
Human Platelets ◽  
Membrane Receptors ◽  
Functional Link ◽  
S Protein ◽  
Phosphatase 2A

Distinct membrane receptors activate platelets by Src-family-kinase (SFK)-, immunoreceptor-tyrosine-based-activation-motif (ITAM)-dependent stimulation of spleen tyrosine kinase (Syk). Recently, we reported that platelet activation via glycoprotein (GP) VI or GPIbα stimulated the well-established Syk tyrosine (Y)-phosphorylation, but also stoichiometric, transient protein kinase C (PKC)-mediated Syk serine(S)297 phosphorylation in the regulatory interdomain-B, suggesting possible feedback inhibition. The transient nature of Syk S297 phosphorylation indicated the presence of an unknown Syk pS297 protein phosphatase. In this study, we hypothesize that the S-protein phosphatase 2A (PP2A) is responsible for Syk pS297 dephosphorylation, thereby affecting Syk Y-phosphorylation and activity in human washed platelets. Using immunoblotting, we show that specific inhibition of PP2A by okadaic acid (OA) alone leads to stoichiometric Syk S297 phosphorylation, as analyzed by Zn2+-Phos-tag gels, without affecting Syk Y-phosphorylation. Pharmacological inhibition of Syk by PRT060318 or PKC by GF109203X only minimally reduced OA-induced Syk S297 phosphorylation. PP2A inhibition by OA preceding GPVI-mediated platelet activation induced by convulxin extended Syk S297 phosphorylation but inhibited Syk Y-phosphorylation. Our data demonstrate a novel biochemical and functional link between the S-protein phosphatase PP2A and the Y-protein kinase Syk in human platelets, and suggest that PP2A represents a potential enhancer of GPVI-mediated Syk activity caused by Syk pS297 dephosphorylation.

2214 Role of protein phosphatase 2A in hippocampal long-term potentiation

1997 ◽  
Vol 28 ◽  
pp. S254
Author(s):  
Kohji Fukunaga ◽  
Dominique Muller ◽  
Masao Ohmitsu ◽  
Eishichi Miyamoto
Keyword(s):  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Phosphatase 2A

scholarly journals Role of Protein Phosphatase 2A in Regulating the Visual Signaling in Drosophila

2008 ◽  
Vol 28 (6) ◽  
pp. 1444-1451 ◽  
Author(s):  
N. Wang ◽  
H.-T. Leung ◽  
W. L. Pak ◽  
Y. T. Carl ◽  
B. E. Wadzinski ◽  
...  
Keyword(s):  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Visual Signaling ◽  
Phosphatase 2A
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