Vascular smooth muscle cell growth-promoting factor/F-spondin inhibits angiogenesis via the blockade of integrin ?v?3 on vascular endothelial cells

2001 ◽  
Vol 188 (3) ◽  
pp. 394-402 ◽  
Author(s):  
Yoshito Terai ◽  
Mayumi Abe ◽  
Kaoru Miyamoto ◽  
Masamichi Koike ◽  
Motoo Yamasaki ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Cell Growth ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Smooth Muscle Cell Growth ◽  
Growth Promoting

Transfer and Expression of the Interferon Gamma Gene in Human Endothelial Cells Inhibits Vascular Smooth Muscle Cell Growth in Vitro

1997 ◽  
Vol 6 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Alison T. Stopeck ◽  
Mahmood Vahedian ◽  
Stuart K. Williams
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Cell Growth ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Smooth Muscle Cell ◽  
Interferon Gamma ◽  
Muscle Cell ◽  
Smooth Muscle Cell Growth

Intimal hyperplasia in blood vessels is primarily caused by the migration and proliferation of vascular smooth muscle cells. Excessive intimal thickening characterizes atherosclerosis as well as bypass graft and angioplasty failures. Endothelial cell-smooth muscle cell interactions and local cytokine production are important regulators of smooth muscle cell growth. Interferon gamma (γ-IFN), a product of T lymphocytes found in atherosclerotic lesions, inhibits smooth muscle cell proliferation in vitro. To determine if local delivery of γ-IFN may be useful in the treatment or prevention of vascular proliferative diseases, we transferred the human γ-IFN gene into endothelial cells isolated from human arteries and microvessels using a retroviral vector. Biologically active γ-IFN was produced and secreted by γ-IFN transduced endothelial cells, but not by control, nontransduced cells, or cells identically transduced with E. coli beta galactosidase (β-gal). To more closely approximate the microenvironment of blood vessels, subconfluent smooth muscle cells were plated in coculture with control, nontransduced endothelial cells, γ-IFN transduced endothelial cells, or β-gal transduced endothelial cells. Smooth muscle cell growth was inhibited 30-70% by coculture with γ-IFN transduced endothelial cells compared to coculture with β-gal transduced or control endothelial cells (p < 0.05). Our results suggest endothelial cells modified to produce γ-IFN may be a useful therapy in proliferative vascular diseases. Copyright © 1997 Elsevier Science Inc.

THE EFFECTS OF LEUKOCYTE 12-LIPOXYGENASE ON ID3 MEDIATED VASCULAR SMOOTH MUSCLE CELL GROWTH

2004 ◽  
Vol 13 (3) ◽  
pp. 59 ◽  
Author(s):  
Angela M Taylor ◽  
Catherine Hedrick ◽  
Jerry Nadler ◽  
Ross Hanchett ◽  
Coleen McNamara
Keyword(s):  
Smooth Muscle ◽  
Cell Growth ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Smooth Muscle Cell Growth ◽  
12 Lipoxygenase

scholarly journals Effects of loop diuretics on angiotensin II‐stimulated vascular smooth muscle cell growth

2001 ◽  
Vol 16 (suppl_1) ◽  
pp. 14-17 ◽  
Author(s):  
Paula Muñiz ◽  
Ana Fortuño ◽  
Guillermo Zalba ◽  
M. Antonia Fortuño ◽  
Javier Díez
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Cell Growth ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Loop Diuretics ◽  
Smooth Muscle Cell Growth

scholarly journals BAY 41‐2272 reduces vascular smooth muscle cell growth via PK‐G & PK‐A signals

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Trisha A Brown ◽  
Natalia N. Mendelev ◽  
Jonathan C. Fox ◽  
Chintamani N. Joshi ◽  
David A. Tulis
Keyword(s):  
Smooth Muscle ◽  
Cell Growth ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Smooth Muscle Cell Growth
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