Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells

2001 ◽  
Vol 188 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Hui-Chiu Chang ◽  
Li-Huang Tsai ◽  
Lea-Yea Chuang ◽  
Wen-Chun Hung
Keyword(s):  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Akt Kinase ◽  
Induced Apoptosis

scholarly journals Functional Role of Caspases in Sphingosine-Induced Apoptosis in Human Hepatoma Cells

IUBMB Life ◽  
2003 ◽  
Vol 55 (7) ◽  
pp. 403-407 ◽  
Author(s):  
Hui-Chiu Chang ◽  
Chin Hsu ◽  
Hseng-Kuang Hsu ◽  
Rei-Cheng Yang
Keyword(s):  
Functional Role ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Induced Apoptosis

scholarly journals Caspase-8 acts as a key upstream executor of mitochondria during justicidin A-induced apoptosis in human hepatoma cells

FEBS Letters ◽  
2006 ◽  
Vol 580 (13) ◽  
pp. 3185-3191 ◽  
Author(s):  
Chun-Li Su ◽  
Lynn L.H. Huang ◽  
Li-Min Huang ◽  
Jenq-Chang Lee ◽  
Chun-Nan Lin ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Caspase 8 ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Induced Apoptosis

844 Protection of transforming factor-beta1-induced apoptosis by beta1-integrin in human hepatoma cells

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 568-568
Author(s):  
I OZAKI ◽  
H ZHANG ◽  
T MIZUTA ◽  
T YOSHIMURA ◽  
S MATSUHASHI ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Beta1 Integrin ◽  
Induced Apoptosis

Abstract 3423: The role of PGC1-α and KLF4 in inhibiting the progression of human hepatoma cells

2011 ◽  
Author(s):  
Chin-Wen Chi ◽  
Ming-Ta Sung ◽  
Ann-Tin Ho ◽  
Chin-Chun Lee ◽  
Wei-Shan Tu ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

scholarly journals Hepatitis C Virus Core Protein Down-Regulates p21Waf1/Cip1 and Inhibits Curcumin-Induced Apoptosis through MicroRNA-345 Targeting in Human Hepatoma Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61089 ◽  
Author(s):  
Tzu-Yue Shiu ◽  
Shih-Ming Huang ◽  
Yu-Lueng Shih ◽  
Heng-Cheng Chu ◽  
Wei-Kuo Chang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Virus Core ◽  
Induced Apoptosis

The role of alpha-fetoprotein in maintaining the growth of human hepatoma cells

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14081-14081
Author(s):  
M. Li ◽  
S. Zhou ◽  
X. Liu ◽  
G. Li
Keyword(s):  
Confocal Microscopy ◽  
Caspase 3 ◽  
Immune Surveillance ◽  
Hepatoma Cells ◽  
Alpha Fetoprotein ◽  
Jurkat Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Apoptosis Related Gene

14081 Background: This study was to explored the functional mechanism of alpha-fetoprotein (AFP) in maintaining the proliferation of human hepatoma cells line Bel 7402 and the immunsuppression of lymphocyte Jurkat cells. Methods: Western blot was used to detecting the expression of some apoptosis-related gene, fluorescence labeled AFP and confocal microscopy scanning for receptor binding assay in the membrane in Jurkat cells. Results: It showed that AFP could enhance the expression of survivin and c-ras, but restrain caspase-3 express in Bel 7402 cells by Western blotting analysis. It also showed that AFP could bind to the membrane of Jurkat cells by confocal microscopy scanning, and when treated Jurkat with AFP, it indicated that AFP could repress the expression of survivin and Livin and elevated the activity of caspase-3 in the cells; Co-cultured Bel 7402 cells with Jurkat cells, the expression of tumor necrosis related-apoptosis induced ligand (TRAIL) in Jurkt cells was inhibited, when pretreatment with monoclonal antibody of AFP (Anti-AFP), the restrained effect of TRAIL express and the activity of caspase-3 was elevated in Jurkat cells was removed. It also indicated that Anti-AFP had an ability to block these functions of AFP. Conclusions: AFP has a capability to promote the growth and escape from immune surveillance of human hepatoma cells through enhancing the expression of ras and survivin gene in Bel 7402 cells, suppressing TRAIL, survivin and Livin expressed and upregulated activity of caspase-3 in Jurkat cells. No significant financial relationships to disclose.

Sign in / Sign up

Export Citation Format

Share Document