Requirement of protein kinase C?, extracellular matrix remodeling, and cell-matrix interaction for transforming growth factor?-regulated expression of E-cadherin and catenins

2001 ◽  
Vol 187 (2) ◽  
pp. 188-195 ◽  
Author(s):  
Hongmei Wang ◽  
Subhas Chakrabarty
Keyword(s):  
Extracellular Matrix ◽  
Protein Kinase C ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Matrix Interaction ◽  
Cell Matrix ◽  
Kinase C ◽  
Regulated Expression

Localization of Transforming Growth Factor-β- Expressing Cells and Comparison with Major Extracellular Components in Aural Cholesteatoma

1997 ◽  
Vol 106 (8) ◽  
pp. 669-673 ◽  
Author(s):  
Stephan Lang ◽  
Volker Schilling ◽  
Brigitte Mack ◽  
Barbara Wollenberg ◽  
Andreas Nerlich
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Matrix Proteins ◽  
Matrix Interaction ◽  
Cell Matrix ◽  
Continuous Band ◽  
Enhanced Expression ◽  
Stimulation Of

Transforming growth factor-β (TGF-β) plays an important role in the regulation of extracellular matrix (ECM) deposition by stimulating the synthesis of individual matrix proteins like tenascin and fibronectin. Cholesteatoma shows significant changes in the ECM, supporting the view of adisturbed cell-matrix interaction. The purpose of our present study was to evaluate the distribution of TGF-β in comparison to the deposition of tenascin, fibronectin, and collagen as major components of the ECM in cholesteatoma (n = 12) by means of histochemistry and immunohistochemistry. We found TGF-P in lymphocytes and fibrohistiocytes in the stroma of 7 cholesteatomas. In corresponding sections, a marked expression of tenascin and fibronectin was seen manifesting as a continuous band along the epidermal-stromal junction, extending to the deeper stroma. In addition, in those cases of TGF-β expression, beginning collagen fibril formation was seen in adjacent deeper stroma layers, indicating beginning stromal fibrosis. These results suggest that TGF-β may be involved in the stimulation of the synthesis of tenascin, fibronectin, and collagen. Furthermore, the enhanced expression of tenascin and fibronectin provides evidence for a deregulated cell-matrix interaction in cholesteatoma associated with the enhanced proliferative process of cholesteatoma formation.

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