Proliferation of human melanoma cells is under tight control of protein kinase C alpha

2004 ◽  
Vol 199 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Konstantin Krasagakis ◽  
Carsten Lindschau ◽  
Sabine Fimmel ◽  
J�rgen Eberle ◽  
Petra Quass ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Tight Control ◽  
Kinase C ◽  
Human Melanoma Cells ◽  
Protein Kinase C Alpha

Lack of protein kinase C (PKC)-β and low PKC-α, -δ, -ε, and -ζ isozyme levels in proliferating human melanoma cells

2002 ◽  
Author(s):  
Konstantin Krasagakis ◽  
Sabine Fimmel ◽  
Daniela Genten ◽  
Jurgen Eberle ◽  
Petra Quas ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Kinase C ◽  
Human Melanoma Cells ◽  
Pkc Β

Deletion of specific protein kinase C subspecies in human melanoma cells

1996 ◽  
Vol 167 (3) ◽  
pp. 406-412 ◽  
Author(s):  
Masahiro Oka ◽  
Kouji Ogita ◽  
Hideya Ando ◽  
Tatsuya Horikawa ◽  
Kazuhito Hayashibe ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Melanoma Cells ◽  
Specific Protein ◽  
Human Melanoma ◽  
Kinase C ◽  
Human Melanoma Cells ◽  
Specific Protein Kinase

scholarly journals Association of protein kinase-C-alpha with cytoplasmic vesicles in melanoma cells.

1996 ◽  
Vol 44 (2) ◽  
pp. 177-182 ◽  
Author(s):  
J Timar ◽  
B Liu ◽  
R Bazaz ◽  
K V Honn
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Fluid Phase ◽  
Subcellular Fractionation ◽  
Melanoma Cells ◽  
Kinase C ◽  
Cytoplasmic Vesicles ◽  
Protein Kinase C Alpha ◽  
Pkc Alpha

In B16a melanoma cells, protein kinase-C-alpha (PKC alpha) is immunomorphologically associated with cytoplasmic vesicles in addition to the previously observed locations (plasma membrane, cytoskeleton, nucleus), as detected with monoclonal antibody (MAb) MC3a. Subcellular fractionation indicated that the authentic 80-KD protein as well as PKC activity can be detected in several particulate fractions except for L2, which contains dense lysosomes. The highest PKC activity is associated with the cytosol-ultralight vesicles and the L1 fraction (containing plasma membrane, endosomes, and the Golgi apparatus). Both of these fractions contained the fluid-phase endocytosis marker peroxidase, indicating that PKC alpha, in addition to other subcellular structures, is most probably associated with endosomal membranes in B16a melanoma cells.

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