Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor cell lines

2003 ◽  
Vol 198 (2) ◽  
pp. 277-294 ◽  
Author(s):  
James S. Liou ◽  
James S. Chen ◽  
Douglas V. Faller
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Kinase C

Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines

1999 ◽  
Vol 44 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Michael J. Kelner ◽  
Trevor C. McMorris ◽  
Mark A. Montoya ◽  
Leita Estes ◽  
Sheldon F. Uglik ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Mgi 114

scholarly journals Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Wilfredo Hernández ◽  
Juan Paz ◽  
Fernando Carrasco ◽  
Abraham Vaisberg ◽  
Evgenia Spodine ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Thiosemicarbazone Complexes ◽  
Benzaldehyde Thiosemicarbazone

The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1(1), 4-phenyl-1-(2′-chloro-benzaldehyde)-thiosemicarbazone, HTSC2(2), 4-phenyl-1-(3′-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3(3), 4-phenyl-1-(2′-naphthaldehyde)-thiosemicarbazone, HTSC4(4), and 4-phenyl-1-(1′-nitro-2′-naphthaldehyde)-thiosemicarbazone, HTSC5(5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and1H- and13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex6shows a square planar geometry with two deprotonated ligands coordinated toPdIIthrough the azomethine nitrogen and thione sulfur atoms in acisarrangement. Thein vitrocytotoxic activity measurements indicate that the palladium(II) complexes (IC50=0.01–9.87 μM) exhibited higher antiproliferative activity than their free ligands (IC50=23.48–70.86 and >250 μM) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 μM, resp.).Corrigendum to “Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines”

scholarly journals Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

1986 ◽  
Vol 261 (29) ◽  
pp. 13754-13759
Author(s):  
N Rosen ◽  
J B Bolen ◽  
A M Schwartz ◽  
P Cohen ◽  
V DeSeau ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Cell ◽  
Cell Lines ◽  
Kinase Activity ◽  
Human Tumor ◽  
Protein Kinase Activity ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Radiobiological Characterization of 53 Human Tumor Cell Lines

1989 ◽  
Vol 56 (5) ◽  
pp. 553-560 ◽  
Author(s):  
Ralph R. Weichselbaum ◽  
Jacob Rotmensch ◽  
Susan Ahmed-Swan ◽  
Michael A. Beckettt
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Abstract B42: Molecular and cytogenetic characterization of novel multidrug-resistant human tumor cell lines

2010 ◽  
Author(s):  
Sabera Ruzdijic ◽  
Ana Podolski-Renic ◽  
Milica Pesic ◽  
Maria Chiourea ◽  
Jasna Bankovic ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Multidrug Resistant ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Cytogenetic Characterization
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