Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts

2003 ◽  
Vol 195 (1) ◽  
pp. 70-79 ◽  
Author(s):  
Emily J. Foulstone ◽  
Paul B. Savage ◽  
Anna L. Crown ◽  
Jeff M.P. Holly ◽  
Claire E.H. Stewart
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Human Adult ◽  
Skeletal Myoblasts ◽  
Igfbp 3

scholarly journals The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Ayfer Altas ◽  
Fatih Kuzu ◽  
Dilek Arpaci ◽  
Mustafa Unal ◽  
Murat Can ◽  
...  
Keyword(s):  
Growth Factor ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Binding Protein ◽  
Serum Levels ◽  
Needle Aspiration ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Igfbp 3

Aim.Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases.Materials and Methods.In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples.Results.The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 μg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 μg/ml) (p<0.01). Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043). A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042,r=0.23).Conclusion.This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules.

scholarly journals Emerging role of insulin-like growth factor-binding protein 7 in hepatocellular carcinoma

2014 ◽  
pp. 9
Author(s):  
Devanand Sarkar ◽  
Maaged Akiel ◽  
Devaraja Rajasekaran ◽  
Rachel Gredler ◽  
Ayesha Siddiq ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Malnutrition in children associated with low insulin-like growth factor binding protein-3 (IGFBP-3) levels

2021 ◽  
Vol 35 ◽  
pp. S275-S277
Author(s):  
Dwi Ayu Rahmawati ◽  
Aminuddin Aminuddin ◽  
Firdaus Hamid ◽  
Prihantono Prihantono ◽  
Burhanuddin Bahar ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Igfbp 3
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