Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro

2002 ◽  
Vol 190 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Joan M. Lemire ◽  
Mervyn J. Merrilees ◽  
Kathleen R. Braun ◽  
Thomas N. Wight
Keyword(s):  
Smooth Muscle ◽  
Cell Adhesion ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle ◽  
Proliferation In Vitro

An In Vitro Study of Nano-fiber Polymers for Guided Vascular Regeneration

2001 ◽  
Vol 711 ◽  
Author(s):  
Derick C. Miller ◽  
Anil Thapa ◽  
Karen M. Haberstroh ◽  
Thomas J. Webster
Keyword(s):  
Smooth Muscle ◽  
Cell Adhesion ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Surrounding Tissue ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle ◽  
Cell Functions ◽  
Fiber Dimensions

ABSTRACTBiomaterials that successfully integrate into surrounding tissue should match not only the tissue's mechanical properties, but also the dimensions of the associated nano-structured extra-cellular matrix (ECM) components. The goal of this research was to use these ideals to develop a synthetic, nano-structured, polymeric biomaterial that has cytocompatible and mechanical behaviors similar to that of natural vascular tissue. In a novel manner, poly-lactic acid/polyglycolic acid (PLGA) (50/50 wt.% mix) and polyurethane were separately synthesized to possess a range of fiber dimensions in the micron and nanometer regime. Preliminary results indicated that decreasing fiber diameter on both PLGA and PU enhanced arterial smooth muscle cell adhesion; specifically, arterial smooth muscle cell adhesion increased 23% when PLGA fiber dimensions decreased from 500 to 50 nm and increased 76% on nano-structured, compared to conventional structured, polyurethane. However, nano-structured PLGA decreased endothelial cell adhesion by 52%, whereas adhesion of these same cells was increased by 50% on polyurethane. For these reasons, the present in vitro study provides the first evidence that polymer fiber dimensions can be used to selectively control cell functions for vascular prosthesis.

Heparinase III limits rat arterial smooth muscle cell proliferation in vitro and in vivo

1998 ◽  
Vol 351 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Paul J Silver ◽  
Jean-Pierre Moreau ◽  
Elizabeth Denholm ◽  
YongQing Lin ◽  
Linh Nguyen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Smooth Muscle Cell Proliferation ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle ◽  
Proliferation In Vitro

Sodium spirulan as a potent inhibitor of arterial smooth muscle cell proliferation in vitro

Life Sciences ◽  
2004 ◽  
Vol 74 (19) ◽  
pp. 2431-2439 ◽  
Author(s):  
Toshiyuki Kaji ◽  
Maiko Okabe ◽  
Satomi Shimada ◽  
Chika Yamamoto ◽  
Yasuyuki Fujiwara ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Potent Inhibitor ◽  
Smooth Muscle Cell Proliferation ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle ◽  
Proliferation In Vitro
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