Can Low-Cost Strategies Improve Attendance Rates in Brief Psychological Therapy? Double-Blind Randomized Controlled Trial

2015 ◽  
Vol 71 (12) ◽  
pp. 1139-1152 ◽  
Author(s):  
Jaime Delgadillo ◽  
Omar Moreea ◽  
Elizabeth Murphy ◽  
Shehzad Ali ◽  
Joshua K. Swift
Keyword(s):  
Randomized Controlled Trial ◽  
Low Cost ◽  
Controlled Trial ◽  
Psychological Therapy ◽  
Attendance Rates ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals Neural predictors of treatment response to brain stimulation and psychological therapy in depression: a double-blind randomized controlled trial

2019 ◽  
Vol 44 (9) ◽  
pp. 1613-1622 ◽  
Author(s):  
Camilla L. Nord ◽  
D. Chamith Halahakoon ◽  
Tarun Limbachya ◽  
Caroline Charpentier ◽  
Níall Lally ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Response ◽  
Brain Stimulation ◽  
Controlled Trial ◽  
Psychological Therapy ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals 3-in-1 Block with Bupivacaine VS Bupivacaine Plus Dexamethasone in Acute Pain Control for Patients Undergoing Hip Nailing Surgery: A Double Blind Randomized Controlled Trial

2020 ◽  
pp. 40-46
Author(s):  
Afshin, Amini ◽  
Arash, Farbood ◽  
Seyed Masoud, Hashemi ◽  
Mehrdad, Taheri ◽  
Amin Reza, Khaledi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Nerve Block ◽  
Low Cost ◽  
Controlled Trial ◽  
Postoperative Pain Management ◽  
Case Group ◽  
Double Blind ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Vas Scores

Background: Femoral 3-in-1 block is one of the most effective methods in cases of hip nailing surgery because of its ease, low cost, and fewer complications. This study aims to evaluate the effect of adding dexamethasone to peripheral nerve block solution. Methods: Forty-four ASA (I,II & III) patients aged between 50-80 years, scheduled for elective hip-nailing surgery who met inclusion and exclusion criteria were enrolled in this double blind randomized controlled trial. Patients were allocated into two groups randomly; at the end of the surgery, femoral 3-in-1 nerve block was performed with 40 ml of bupivacaine 0.25% solution with or without 8 mg dexamethasone. Pain score was measured for 24 hours. Results: We found no significant difference in pain intensity scores until hour 0.5 and the scores were below 1. Thereafter, the VAS scores increased, yet it remained below 3 in the first 12 postoperative hours. Morphine was administered during hours 12-24 in both groups, when VAS scores reached to about 4. The total amount of morphine consumption was a little lower in the case group, although the difference was not statistically significant. Conclusion: Adding dexamethasone to bupivacaine 0.25% for 3-in-1 block has no more benefit than bupivacaine 0.25% alone for acute postoperative pain management after elective hip nailing surgery.

scholarly journals Randomized Controlled Trial of Early Outpatient COVID-19 Treatment with High-Titer Convalescent Plasma

2021 ◽  
Author(s):  
David J Sullivan ◽  
Kelly A Gebo ◽  
Shmuel Shoham ◽  
Evan M Bloch ◽  
Bryan Lau ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
High Titer ◽  
Low Cost ◽  
Controlled Trial ◽  
Placebo Control ◽  
Double Blind ◽  
Recent Onset ◽  
Intention To Treat ◽  
Randomized Controlled ◽  
Control Plasma

BACKGROUND: The efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain. METHODS: This multicenter, double-blind randomized controlled trial compared the efficacy and safety of SARS-CoV-2 high titer convalescent plasma to placebo control plasma in symptomatic adults >18 years positive for SARS-CoV-2 regardless of risk factors for disease progression or vaccine status. Participants with symptom onset within 8 days were enrolled, then transfused within the subsequent day. The measured primary outcome was COVID-19-related hospitalization within 28 days of plasma transfusion. The enrollment period was June 3, 2020 to October 1, 2021. RESULTS: A total of 1225 participants were randomized and 1181 transfused. In the pre-specified modified intention-to-treat analysis that excluded those not transfused, the primary endpoint occurred in 37 of 589 (6.3%) who received placebo control plasma and in 17 of 592 (2.9%) participants who received convalescent plasma (relative risk, 0.46; one-sided 95% upper bound confidence interval 0.733; P=0.004) corresponding to a 54% risk reduction. Examination with a model adjusting for covariates related to the outcome did not change the conclusions. CONCLUSION: Early administration of high titer SARS-CoV-2 convalescent plasma reduced outpatient hospitalizations by more than 50%. High titer convalescent plasma is an effective early outpatient COVID-19 treatment with the advantages of low cost, wide availability, and rapid resilience to variant emergence from viral genetic drift in the face of a changing pandemic.

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial

2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled
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