scholarly journals Simultaneous disruption of circulating miR‐21 and cytotoxic T lymphocytes (CTLs): Prospective diagnostic and prognostic markers for esophageal squamous cell carcinoma (ESCC)

2021 ◽  
Author(s):  
Hadiseh Samiei ◽  
Faezeh Ajam ◽  
Abdolsamad Gharavi ◽  
Sara Abdolmaleki ◽  
Parviz Kokhaei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Lymphocytes ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cytotoxic T Lymphocytes ◽  
Squamous Cell ◽  
Prognostic Markers

SART1 Gene Encoding Squamous Cell Carcinoma Antigen Recognized by Cytotoxic T Lymphocytes

Cell Therapy ◽  
2000 ◽  
pp. 15-28
Author(s):  
Kyogo Itoh ◽  
Shigeki Shichijo ◽  
Yoshiko Inoue ◽  
Akihiro Hayashi ◽  
Uhi Toh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Lymphocytes ◽  
Cell Carcinoma ◽  
Cytotoxic T Lymphocytes ◽  
Squamous Cell ◽  
Squamous Cell Carcinoma Antigen ◽  
Gene Encoding

scholarly journals Clonal Expansion of Tumor-Infiltrating T Cells and Analysis of the Tumor Microenvironment within Esophageal Squamous Cell Carcinoma Relapsed after Definitive Chemoradiation Therapy

2021 ◽  
Vol 22 (3) ◽  
pp. 1098
Author(s):  
Takahiro Mori ◽  
Kenichi Kumagai ◽  
Keisuke Nasu ◽  
Takamasa Yoshizawa ◽  
Koji Kuwano ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Healthy Volunteers ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Markers ◽  
Clonal Expansion ◽  
Diversity Indices ◽  
Chemoradiation Therapy ◽  
Definitive Chemoradiation

(1) Background: Comparable prognoses after definitive chemoradiation therapy (CRT) to surgery alone for esophageal squamous cell carcinoma (ESCC) have been previously reported; however, no robust prognostic markers have been established. The clonality of tumor-infiltrating lymphocytes (TILs) and tumor microenvironments (TMEs) in ESCC relapsed after CRT were examined to explore prognostic markers. (2) Methods: Clonality of TIL and TME were examined in ESCC with and without preceding CRT, as well as oral squamous cell carcinoma (OSCC) and healthy volunteers as controls. The clonality of TIL was assessed by T-cell receptor (TCR) α and β repertoire analyses and evaluated by diversity indices. The TME was assessed by quantitative polymerase chain reaction evaluating PD-L1 and CD8B. (3) Results: The clonal expansion of TIL was significantly induced within ESCCs and OSCCs, when compared to healthy volunteers, and was mostly induced within ESCCs after definitive CRT. Diversity indices of TIL were not associated with the prognosis, but the ratio of PD-L1 mRNA to CD8B mRNA in TME was significantly associated with a poor prognosis after salvage surgery (p = 0.007). (4) Conclusions: The clonal expansion of TIL is induced after definitive CRT for ESCC, and the ratio of PD-L1 mRNA to CD8B mRNA within tumor tissues is a prognostic marker candidate for salvage esophagectomy after CRT.

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