scholarly journals Late onset of type 2 diabetes is associated with mitochondrial tRNA Trp A5514G and tRNA Ser(AGY) C12237T mutations

2021 ◽  
Author(s):  
Liuchun Yang ◽  
Qinxian Guo ◽  
Jianhang Leng ◽  
Keyi Wang ◽  
Yu Ding
Keyword(s):  
Type 2 Diabetes ◽  
Late Onset ◽  
Mitochondrial Trna

HNF-4α: from MODY to late-onset type 2 diabetes

2004 ◽  
Vol 10 (11) ◽  
pp. 521-524 ◽  
Author(s):  
Rana K. Gupta ◽  
Klaus H. Kaestner
Keyword(s):  
Type 2 Diabetes ◽  
Late Onset ◽  
Onset Type

scholarly journals Mutational Analysis of Mitochondrial tRNA Genes in 200 Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol Volume 14 ◽  
pp. 5719-5735
Author(s):  
Liangyan Lin ◽  
Dongdong Zhang ◽  
Qingsong Jin ◽  
Yaqin Teng ◽  
Xiaoyan Yao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mutational Analysis ◽  
Trna Genes ◽  
Mitochondrial Trna ◽  
Mitochondrial Trna Genes

scholarly journals Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

2019 ◽  
Vol 9 (10) ◽  
pp. 262 ◽  
Author(s):  
Hayden
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Type 2 Diabetes Mellitus ◽  
Late Onset ◽  
Neurovascular Unit ◽  
Age Related ◽  
Increased Risk

Type 2 diabetes mellitus (T2DM) and late-onset Alzheimer’s disease–dementia (LOAD) are increasing in global prevalence and current predictions indicate they will only increase over the coming decades. These increases may be a result of the concurrent increases of obesity and aging. T2DM is associated with cognitive impairments and metabolic factors, which increase the cellular vulnerability to develop an increased risk of age-related LOAD. This review addresses possible mechanisms due to obesity, aging, multiple intersections between T2DM and LOAD and mechanisms for the continuum of progression. Multiple ultrastructural images in female diabetic db/db models are utilized to demonstrate marked cellular remodeling changes of mural and glia cells and provide for the discussion of functional changes in T2DM. Throughout this review multiple endeavors to demonstrate how T2DM increases the vulnerability of the brain’s neurovascular unit (NVU), neuroglia and neurons are presented. Five major intersecting links are considered: i. Aging (chronic age-related diseases); ii. metabolic (hyperglycemia advanced glycation end products and its receptor (AGE/RAGE) interactions and hyperinsulinemia-insulin resistance (a linking linchpin); iii. oxidative stress (reactive oxygen–nitrogen species); iv. inflammation (peripheral macrophage and central brain microglia); v. vascular (macrovascular accelerated atherosclerosis—vascular stiffening and microvascular NVU/neuroglial remodeling) with resulting impaired cerebral blood flow.

scholarly journals Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes

Diabetes Care ◽  
2000 ◽  
Vol 23 (10) ◽  
pp. 1533-1538 ◽  
Author(s):  
J. Rissanen ◽  
H. Wang ◽  
R. Miettinen ◽  
P. Karkkainen ◽  
P. Kekalainen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Late Onset ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Onset Type ◽  
Chinese Subjects

scholarly journals Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

1999 ◽  
Vol 104 (9) ◽  
pp. R41-R48 ◽  
Author(s):  
El Habib Hani ◽  
Doris A. Stoffers ◽  
Jean-Claude Chèvre ◽  
Emmanuelle Durand ◽  
Violeta Stanojevic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Late Onset ◽  
Onset Type ◽  
Insulin Promoter
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