scholarly journals A method for measuring the experimental resolution of laboratory assays (clinical biochemical, blood count, immunological, and qPCR) to evaluate analytical performance

2021 ◽  
Author(s):  
Chenxi Sun ◽  
Dongxia Wang ◽  
Henggui Xu ◽  
Guang Yang ◽  
Xiaomei Yan ◽  
...  
Keyword(s):  
Blood Count ◽  
Analytical Performance ◽  
Experimental Resolution

Basophil counting in hematology analyzers: time to discontinue?

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Johannes J. M. L. Hoffmann
Keyword(s):  
Clinical Relevance ◽  
Blood Count ◽  
Complete Blood Count ◽  
Analytical Performance ◽  
Physical Methods ◽  
Alternative Pathways ◽  
Analytical Imprecision ◽  
Very High ◽  
Hematology Analyzers ◽  
Performance Demands

AbstractBasophils (basophilic granulocytes) are the least abundant cells in blood. Nowadays, basophils are included in the complete blood count performed by hematology analyzers and therefore reported in practically all patients in whom hematologic investigations are requested. However, hematology analyzers are not reliable enough to report clinically useful results. This is due to a combination of very high analytical imprecision and poor specificity, because the chemical and physical methods used for basophil counting in hematology analyzers are ill-defined and thus basophils are not well recognized by the analyzers. As a result, false basophil counts are quite common. In view of increasing analytical performance demands, hematology laboratories should stop reporting basophil counts produced by hematology analyzers. Suggestions for alternative pathways are presented for those situations where basophils are of clinical relevance.

Beyond Blood Count: Check Iron for Unexplained Fatigue

2006 ◽  
Vol 37 (1) ◽  
pp. 37
Author(s):  
Patrice Wendling
Keyword(s):  
Blood Count

Analytical Performance of New ARCHITECT AFP Assay: Comparison with the Current Assay

2018 ◽  
Vol 8 (2) ◽  
pp. 62
Author(s):  
Kwang-Sook Woo ◽  
Gyu-Dae An ◽  
Hyeon-Ho Lim ◽  
Jin-Yeong Han
Keyword(s):  
Analytical Performance
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