scholarly journals Association between urinary VEGFA and renal pathology of IgA nephropathy patients

2021 ◽  
Author(s):  
Shaozhen Feng ◽  
Naya Huang ◽  
Miaorong Xue ◽  
Puhua Zhang ◽  
Zhong Zhong ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Renal Pathology

scholarly journals Renal Pathology in Two Chinese Patients with Concomitant IgG4-Related Disease (IgG4-RD) and IgA Nephropathy (IgAN)

2015 ◽  
Vol 17 (2) ◽  
pp. S36
Author(s):  
C.K.Y. Poon ◽  
H.L. Tang ◽  
Y.F. Mak ◽  
H.M. Cheng ◽  
L.Y. Wong ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Renal Pathology ◽  
Chinese Patients ◽  
Related Disease ◽  
Igg4 Related Disease

scholarly journals P0114BENEFITS AND CHALLENGES OF A RENAL BIOPSY REGISTRY AND NETWORK - FCGG EXPERIENCE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Wim Laurens ◽  
Johan De Meester ◽  
Ben Sprangers ◽  
Steven Van Laecke ◽  
Dendooven Amélie ◽  
...  
Keyword(s):  
Renal Disease ◽  
Renal Biopsy ◽  
Iga Nephropathy ◽  
Clinical Care ◽  
Adult Population ◽  
Age Groups ◽  
Time Frame ◽  
Renal Pathology ◽  
Renal Diseases ◽  
Renal Biopsies

Abstract Background and Aims End December 2016, a renal biopsy network in the Flemish region (Belgium) was founded as a collaboration between the renal pathologists and nephrologists. This FCGG network introduced a uniform renal biopsy request form, a well-structured report form of the renal pathology examination and a comprehensive list of renal pathology diagnoses. Method Following informed consent [99.5%] and in compliance with GDPR, the registration of the renal biopsies consists of basic categorical renal data, structured renal pathology information and the final clinical renal disease. Results In 2017 and 2018, 1385 renal biopsies were registered – 10.5 per million inhabitants per year; in addition, 28 patients had a repeat biopsy in the same time frame (2%). Of the pediatric patients ( age < 18 years; N=92; 6.6%), 23 had IgA nephropathy, 20 a minimal change disease and 15 another type of glomerulonephritis. The biopsy was reported as normal or non-diagnostic in 15 patients (16%) – the majority was clinically considered as glomerulonephritis. The spectrum of the adult population was quite similar across gender and age groups: 56% glomerulonephritis [= IgA nephropathy [19%] + FSGS [8%] + pauci-immune glomerulonephritis [7%] + other GN [22%] ), 10% tubulo-interstitial nephritis, 7% acute tubular necrosis [ATN], 7% diabetes mellitus, and 7% nephroangiosclerosis. Exceptions are pauci-immune glomerulonephritis as the most important renal disease in women aged 65 years and older, and lupus nephritis as the second most important glomerulonephritis in women aged 18-44 years. Only a small percentage of adult renal biopsies yielded no result (7%), clinically interpreted as glomerulonephritis in 50% of the cases. Conclusion The FCGG network has provided a more intense collaboration between renal pathologists and nephrologists mainly by standardizing the renal biopsy reading and reporting across all centers. More precise estimates of the prevalent renal diseases were provided for the first time; however, in order to get full information, renal diseases diagnosed by other techniques ( serology, genetic analysis ) should also be collected in the future. Efforts will be done to coordinate the clinical care of renal diseases, particularly the more rare renal diseases, and to offer access to new therapeutic molecules or new schemes, through this super-regional network.

scholarly journals P0134PROTEINURIA IS NOT ALWAYS ASSOCIATED WITH PROGNOSIS IN IGA NEPHROPATHY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Byoung-Soo Cho ◽  
Hyaejin Yun ◽  
Sungmin Jung ◽  
Hyun-soon Lee
Keyword(s):  
Renal Biopsy ◽  
Iga Nephropathy ◽  
Surrogate Marker ◽  
Pulse Therapy ◽  
Methylprednisolone Pulse Therapy ◽  
Renal Pathology ◽  
Crescent Formation ◽  
Methylprednisolone Pulse ◽  
Renal Biopsies

Abstract Background and Aims To date the most widely well studied risk factor for progression to ESRD in patients with IgA nephropathy is proteinuria. Recent report suggests proteinuria reduction as a surrogate end point in trial of IgA nephropathy(2019,CJASN). Sensitivity of most biomarkers such as blood and urine gd-IgA1 level, IgG/IgA autoantibody, sCD89, sCD71, NGAL, KIM-1, Cystatin-C etc were compared with the amount of proteinuria. Most nephrologists do not performing kidney biopsy in patients without proteinuria or proteinuria less than than 500mg/day even though IgA nephropathy is suspected. However we recently experienced severe IgA nephropathy (HSD Lee, grade IV) in patients with normal urinalysis, and more than half the patients showed stationary or aggravated renal pathology at the follow up renal biopsy although urinalysis findings were normalized after methylprednisolone pulse therapy. Method In our center we performed 892 renal biopsies during last 6 years, we experienced 253 IgA nephropathy, of which 152 cases were done follow up renal biopsies to see the pathologic changes who showed normalized urinalysis findings after methylprednisolone pulse therapy. Results Of the 253 patients 241 patients showed initial abnormal urinalysis like hematuria and or proteinuria. However eleven patients showed normal urinalysis at the time of renal biopsy, of which 5 cases were diagnosed as essential hypertension and 6 cases were normal urinalysis associated with lowered GFR. Of the 152 follow up renal biopsies we evaluated 99 cases who showed normalized urinalysis findings after therapy, of which 65 cases(65.7%) showed stationary or aggravated renal pathology. Conclusion In conclusion further long term studies are needed, proteinuria could not be a surrogate marker for prognosis of the IgA nephropathy, Regardless of proteinuria if associated with hypertension and or lowered GFR, renal biopsy should be done. Follow up renal biopsy might be needed to confirm the healing of IgA nephropathy regardless of urinary findings to see the disappearance of IgA deposition, decreasing mesangial and endocapillary hypercellularity, disappearance of crescent formation, decreasing sclerosis, etc.

scholarly journals AJKD Atlas of Renal Pathology: IgA Nephropathy

2015 ◽  
Vol 66 (5) ◽  
pp. e33-e34 ◽  
Author(s):  
Agnes B. Fogo ◽  
Mark A. Lusco ◽  
Behzad Najafian ◽  
Charles E. Alpers
Keyword(s):  
Iga Nephropathy ◽  
Renal Pathology

scholarly journals The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Tsutomu Nomura ◽  
Yoshimi Makizumi ◽  
Tsuyoshi Yoshida ◽  
Tatsuya Yamasoba
Keyword(s):  
Prognostic Factor ◽  
Retrospective Analysis ◽  
Iga Nephropathy ◽  
Reduction Rate ◽  
Renal Pathology ◽  
Pathological Findings ◽  
Improvement Rate ◽  
Significant Difference ◽  
The Relationship

Objective.The aim of this study was to evaluate the effects of tonsillectomy as a treatment for IgA nephropathy in relation to renal pathological findings.Methods.This is a retrospective analysis of 13 patients having IgA nephropathy treated by tonsillectomy.Results.UP/UCre levels decreased from 820.8 to 585.4 one month postsurgery and then showed slight worsening to 637.3 at the most recent follow-up. There was no significant difference in the improvement rate between pathological grades I–III and IV. There was positive correlation between Pre-UP/UCre level and the reduction rate of UP/UCre, which was statistically significant (R = 0.667,R2 = 0.445, andP=0.01).Conclusions.Reduction of UP/UCre at one month postsurgery is considered to be an overall prognostic factor, and tonsillectomy is considered to be an effective therapy for IgA patients regardless of the grade of renal pathology.

Interstitial inflammation and the expression of apoptotic modulators in iga nephropathy

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A114-A114
Author(s):  
Menahem Sa ◽  
Maguire Ja ◽  
Stein‐Oakley A ◽  
Bailey M ◽  
Dowling J ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Interstitial Inflammation
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