scholarly journals Retraction statement: A landscape of circulating long non‐coding RNA (IncRNA) expression profile and the predictive value of candidate IncRNAs for disease risk of knee osteoarthritis

2020 ◽  
Vol 34 (12) ◽  
Keyword(s):  
Knee Osteoarthritis ◽  
Expression Profile ◽  
Predictive Value ◽  
Disease Risk ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Endogenous intronic antisense long non-coding RNA, MGAT3-AS1, and kidney transplantation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Subagini Nagarajah ◽  
Shengqiang Xia ◽  
Marianne Rasmussen ◽  
Martin Tepel
Keyword(s):  
Kidney Transplantation ◽  
Predictive Value ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function ◽  
Transplant Recipients ◽  
Donor Kidney ◽  
Non Coding Rna ◽  
Deceased Donor Kidney ◽  
Long Non Coding Rna

Abstract β-1,4-mannosylglycoprotein 4-β-N-acetylglucosaminyltransferase (MGAT3) is a key molecule for the innate immune system. We tested the hypothesis that intronic antisense long non-coding RNA, MGAT3-AS1, can predict delayed allograft function after kidney transplantation. We prospectively assessed kidney function and MGAT3-AS1 in 129 incident deceased donor kidney transplant recipients before and after transplantation. MGAT3-AS1 levels were measured in mononuclear cells using qRT-PCR. Delayed graft function was defined by at least one dialysis session within 7 days of transplantation. Delayed graft function occurred in 22 out of 129 transplant recipients (17%). Median MGAT3-AS1 after transplantation was significantly lower in patients with delayed graft function compared to patients with immediate graft function (6.5 × 10−6, IQR 3.0 × 10−6 to 8.4 × 10−6; vs. 8.3 × 10−6, IQR 5.0 × 10−6 to 12.8 × 10−6; p < 0.05). The median preoperative MGAT3-AS1 was significantly lower in kidney recipients with delayed graft function (5.1 × 10−6, IQR, 2.4 × 10−6 to 6.8 × 10−6) compared to recipients with immediate graft function (8.9 × 10−6, IQR, 6.8 × 10−6 to 13.4 × 10−6; p < 0.05). Receiver-operator characteristics showed that preoperative MGAT3-AS1 predicted delayed graft function (area under curve, 0.83; 95% CI, 0.65 to 1.00; p < 0.01). We observed a positive predictive value of 0.57, and a negative predictive value of 0.95. Long non-coding RNA, MGAT3-AS1, indicates short-term outcome in patients with deceased donor kidney transplantation.

scholarly journals A long-non-coding RNA, LINC00473, confers the human adipose tissue thermogenic phenotype through enhanced cAMP responsiveness

2018 ◽  
Author(s):  
Khanh-Van Tran ◽  
Cecilie Nandrup-Bus ◽  
Tiffany DeSouza ◽  
Ricardo Soares ◽  
Naja Zenius Jespersen ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Adipose Tissue ◽  
Disease Risk ◽  
Human Adipose Tissue ◽  
Non Coding Rna ◽  
Highly Correlated ◽  
Thermogenic Adipocytes ◽  
The Many ◽  
External Stimuli ◽  
Long Non Coding Rna

SummarySpecialized adipocytes localized in distinct depots mediate the many physiological functions of adipose tissue. In humans, paucity of thermogenic adipocytes correlates with high metabolic disease risk, raising much interest in the mechanisms by which these cells arise. Here we report molecular signatures associated with adipocyte development in different human depots and identify a long non-coding RNA, LINC00473, as the transcript most closely associated with enrichment of thermogenic adipocytes. LINC00473 expression is low in subjects with obesity or type-2 diabetes and is highly correlated with cAMP signaling and mitochondrial oxidative phosphorylation pathways. LINC00473 is localized in the nucleus and the cytoplasm, and its knockdown impairs induction of UCP1 and mitochondrial respiration. These results reveal that depot-enriched genes that modulate responsiveness to external stimuli, specifically LINC00473, are important determinants of the adipose tissue thermogenic phenotype, and potential targets for metabolic disease therapy.

scholarly journals Analysis of Long Non-Coding RNA Expression Profile and Functional Study of LOC389332 in Early Gastric Cancer

2019 ◽  
Vol 25 ◽  
pp. 10114-10121
Author(s):  
Hang Yu ◽  
Ai-ming Yang ◽  
Xing-hua Lu ◽  
Lin Feng ◽  
Xi Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Expression Profile ◽  
Functional Study ◽  
Rna Expression ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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