scholarly journals Long non‐coding RNA T‐cell factor 7 in multiple myeloma: A potential biomarker for deteriorated clinical features and poor prognosis

2020 ◽  
Vol 34 (9) ◽  
Author(s):  
Cui Zhang ◽  
Min Chu ◽  
Yingchao Fan ◽  
Liting Wu ◽  
Zhumeng Li ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
T Cell ◽  
Clinical Features ◽  
Poor Prognosis ◽  
T Cell Factor ◽  
Non Coding Rna ◽  
Potential Biomarker ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating the microRNA-34a-5p/NOTCH1 signaling pathway

2020 ◽  
Vol 15 (1) ◽  
pp. 284-295
Author(s):  
Yongtian Zhang ◽  
Dandan Zhao ◽  
Shumei Li ◽  
Meng Xiao ◽  
Hongjing Zhou ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Signaling Pathway ◽  
Notch Receptor ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Notch1 Signaling ◽  
Non Coding Rna ◽  
Notch1 Signaling Pathway ◽  
Long Non Coding Rna

AbstractMultiple myeloma (MM) is a serious health issue in hematological malignancies. Long non-coding RNA taurine-upregulated gene 1 (TUG1) has been reported to be highly expressed in the plasma of MM patients. However, the functions of TUG1 in MM tumorigenesis along with related molecular basis are still undefined. In this study, increased TUG1 and decreased microRNA-34a-5p (miR-34a-5p) levels in MM tissues and cells were measured by the real-time quantitative polymerase reaction assay. The expression of relative proteins was determined by the Western blot assay. TUG1 knockdown suppressed cell viability, induced cell cycle arrest and cell apoptosis in MM cells, as shown by Cell Counting Kit-8 and flow cytometry assays. Bioinformatics analysis, luciferase reporter assay, and RNA pull-down assay indicated that miR-34a-5p was a target of TUG1 and directly bound to notch receptor 1 (NOTCH1), and TUG1 regulated the NOTCH1 expression by targeting miR-34a-5p. The functions of miR-34a-5p were abrogated by TUG1 upregulation. Moreover, TUG1 loss impeded MM xenograft tumor growth in vivo by upregulating miR-34a-5p and downregulating NOTCH1. Furthermore, TUG1 depletion inhibited the expression of Hes-1, Survivin, and Bcl-2 protein in MM cells and xenograft tumors. TUG1 knockdown inhibited MM tumorigenesis by regulating the miR-34a-5p/NOTCH1 signaling pathway in vitro and in vivo, deepening our understanding of the TUG1 function in MM.

Low absolute CD4+ T cell counts in peripheral blood predict poor prognosis in patients with newly diagnosed multiple myeloma

2020 ◽  
Vol 61 (8) ◽  
pp. 1869-1876 ◽  
Author(s):  
Yan Gu ◽  
Yuanyuan Jin ◽  
Jie Ding ◽  
Wu Yujie ◽  
Qinglin Shi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
T Cell ◽  
Peripheral Blood ◽  
Poor Prognosis ◽  
Cd4 T Cell ◽  
Newly Diagnosed ◽  
Cell Counts

scholarly journals Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

2019 ◽  
Vol 51 (9) ◽  
pp. 1337-1343 ◽  
Author(s):  
Gaëlle Angenard ◽  
Aude Merdrignac ◽  
Corentin Louis ◽  
Julien Edeline ◽  
Cédric Coulouarn
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Poor Prognosis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer

2017 ◽  
Vol 359 (1) ◽  
pp. 185-194 ◽  
Author(s):  
Yuan Cao ◽  
Huirong Shi ◽  
Fang Ren ◽  
Yanyan Jia ◽  
Ruitao Zhang
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Poor Prognosis ◽  
Non Coding Rna ◽  
Long Non Coding Rna
Sign in / Sign up

Export Citation Format

Share Document