scholarly journals LncRNA H19 gene rs2839698 polymorphism is associated with a decreased risk of colorectal cancer in a Chinese Han population: A case‐control study

2020 ◽  
Vol 34 (8) ◽  
Author(s):  
Bingqu Yu ◽  
Jiayuan Chen ◽  
Chenfeng Hou ◽  
Lei Zhang ◽  
Jie Jia
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
H19 Gene ◽  
Control Study

MMP-2, -3 and TIMP-2, -3 polymorphisms in colorectal cancer in a Chinese Han population: A case-control study

Gene ◽  
2020 ◽  
Vol 730 ◽  
pp. 144320
Author(s):  
Nan Wang ◽  
Shuai Zhou ◽  
Xiong-Chao Fang ◽  
Peng Gao ◽  
Qing Qiao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Control Study

scholarly journals IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hong Ji ◽  
Le Lu ◽  
Jingjing Huang ◽  
Yang Liu ◽  
Binchao Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factor ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Control Study

C5orf66 rs4976270/rs639933 Are Associated with Colorectal Cancer Risk in Southern Chinese Han Population: A Case-Control Study

Digestion ◽  
2021 ◽  
pp. 1-13
Author(s):  
Xingyun Zhan ◽  
Fenghua Bai ◽  
Sifeng Lin ◽  
Tao Feng ◽  
Xiaosi Tang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Candidate Snps ◽  
Chinese Han ◽  
Han Population ◽  
Southern Chinese ◽  
Increased Risk ◽  
Control Study

<b><i>Background:</i></b> Colorectal cancer (CRC) is one of the common malignant tumors, with high mortality and poor prognosis. Our study aimed to determine the association between the long noncoding RNA (LncRNA) <i>C5orf66</i> polymorphism and CRC risk in southern Chinese Han population. <b><i>Method:</i></b> Using the experimental design of “case-control” study (512 cases and 513 controls), we selected 4 candidate single-nucleotide polymorphisms (SNPs) of <i>C5orf66</i>. All candidate SNPs were genotyped by Agena MassARRAY. Logistic regression was used to analyze the association between SNPs and CRC risk. Then, we used false-positive report probability analysis to detect whether the significant result is just a chance or noteworthy observation. Multi-factor dimensionality reduction was used to analyze the interaction of “SNP-SNP” in CRC risk. <b><i>Results:</i></b> Our results showed that <i>C5orf66</i> SNPs rs4976270 (odds ratio [OR] = 1.69, <i>p</i> = 0.021) and rs639933 (OR = 1.67, <i>p</i> = 0.024) were, respectively, associated with increasing CRC risk in the southern Chinese Han population. Stratified analysis showed that rs4976270 and rs639933 were significantly associated with an increased risk of CRC in subgroups (&#x3e;60 years, body mass index ≤24 and drinking) under multiple genetic models. In addition, rs254563 and rs647161 also had potential association with CRC risk in subgroups (BMI ≤24 and drinking). Finally, haplotype analysis results showed that haplotype “TA” was significantly associated with increased CRC risk (OR = 1.21, confidence interval = 1.47–2.02, <i>p</i> = 0.043). <b><i>Conclusion:</i></b> Our study provides a new idea for the risk assessment of CRC. LncRNA C5orf66 SNPs have a certain association with CRC risk in the southern Chinese Han population.

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