scholarly journals Precipitated sdLDL: An easy method to estimate LDL particle size

2020 ◽  
Vol 34 (7) ◽  
Author(s):  
Bárbara Fernández‐Cidón ◽  
Beatriz Candás‐Estébanez ◽  
Josep Ribalta ◽  
Edmond Rock ◽  
Montserrat Guardiola‐Guionnet ◽  
...  
Keyword(s):  
Particle Size ◽  
Easy Method ◽  
Ldl Particle Size

The total apolipoprotein B/LDL-cholesterol ratio does not predict LDL particle size

1995 ◽  
Vol 240 (1) ◽  
pp. 63-73 ◽  
Author(s):  
G.A. Tallis ◽  
M.D.S. Shephard ◽  
S. Sobecki ◽  
M.J. Whiting
Keyword(s):  
Particle Size ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Ldl Particle Size ◽  
Cholesterol Ratio

Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia

2002 ◽  
Vol 144 (4) ◽  
pp. G1-G8 ◽  
Author(s):  
Vojtech Melenovsky ◽  
Jan Malik ◽  
Dan Wichterle ◽  
Jan Simek ◽  
Alexandra Pisarikova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Particle Size ◽  
Ldl Particle Size

Lipoprotein(a) and LDL Particle Size Are Related to the Severity of Coronary Artery Disease

Cardiology ◽  
2007 ◽  
Vol 108 (4) ◽  
pp. 282-289 ◽  
Author(s):  
Jae-Youn Moon ◽  
Hyuck Moon Kwon ◽  
Sung Woo Kwon ◽  
Se-Jung Yoon ◽  
Jung-Sun Kim ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Particle Size ◽  
Coronary Artery ◽  
Ldl Particle Size ◽  
Lipoprotein A ◽  
Artery Disease

Abstract P198: Does Cetp Mass Contribute to the Response of LDL Particle Size to a 1-yr Lifestyle Modification Program in Viscerally Obese Dyslipidemic Men?

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Emilie Pelletier Beaumont ◽  
Jean Bergeron ◽  
Natalie Alméras ◽  
Angelo Tremblay ◽  
Paul Porier ◽  
...  
Keyword(s):  
Particle Size ◽  
Lifestyle Modification ◽  
Particle Sizes ◽  
Ldl Particle Size ◽  
Transfer Protein ◽  
Ldl Size ◽  
Gradient Gel Electrophoresis ◽  
Lifestyle Modification Program ◽  
One Year ◽  
Visceral Adipose

Numerous studies have demonstrated improvements in lipid and lipoprotein levels with endurance exercise training and weight loss. However, less is known about the contribution of the enzyme cholesteryl ester transfer protein (CETP) to the response of lipoprotein levels to a physical activity/healthy eating lifestyle modification program. Objective: To examine the effect of a 1-year lifestyle modification program inducing loss of visceral adipose tissue on plasma CETP mass in abdominally obese dyslipidemic men. Methods: Plasma CETP mass concentration was measured by ELISA at baseline and after a 1-year lifestyle modification program in 116 abdominally obese men aged 30 to 65 years without diabetes. Visceral adiposity was assessed by computed tomography and a complete fasting plasma lipoprotein-lipid profile was also obtained at baseline and after the intervention. Results: After 1 year, no significant changes were observed in CETP mass (1.91±0.45 vs.1.93±0.49 mg/l, ns). However, both HDL (81.7±2.1 vs. 83.8±3.1 Å, p<0.0001) and LDL (252.1±3.9 vs. 253.6±3.7 Å, p<0.0001) particle sizes assessed by gradient gel electrophoresis were increased. Whereas no significant correlation between change in HDL size and CETP mass was observed, change in LDL size was significantly correlated with change in CETP mass (r=−0.30, p=0.001). We also divided men into two groups: men who showed no change or an increase in their CETP mass (ΔCETP≥0) and men who decreased their CETP mass (ΔCETP<0). Men who reduced their CETP mass after one year showed a greater increase in LDL size (Δ 2.37±3.18 vs.0.32±3.04 Å, p=0.0006) and a greater decrease in triglyceride levels (Δ-0.70±0.86 vs. −0.34±0.80 mmol/l, p=0.03) than men who showed no change or an increase in CETP mass. A Multivariate analysis revealed that 19% of the variance in the response of LDL size could be attributed to changes in triglyceride levels (15%) and in CETP mass (4%) (p=0.02). Conclusion: Whereas no significant change in CETP mass was observed, our results showed that individual variation in the response of CETP mass contributed to the response of LDL particle size to a 1-yr lifestyle modification program in viscerally obese dyslipidemic men.

scholarly journals Lipoprotein cholesterol distribution and LDL particle size is proatherogenic in Mexican Americans with metabolic syndrome

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Giselle Adriana Pereira Pignotti ◽  
Srijana Neupane ◽  
Kristin J Farr ◽  
Sonia Vega-López
Keyword(s):  
Metabolic Syndrome ◽  
Particle Size ◽  
Mexican Americans ◽  
Lipoprotein Cholesterol ◽  
Ldl Particle Size

scholarly journals A very low carbohydrate diet and increased physical activity improve LDL particle size in individuals taking statins

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Erin E Quann ◽  
Kevin D Ballard ◽  
Brian R Kupchak ◽  
Carl M Maresh ◽  
William J Kraemer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Particle Size ◽  
Carbohydrate Diet ◽  
Ldl Particle Size ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

scholarly journals Dietary Saturated Fat Is Associated with Larger LDL Particle Size and Reduced CVD Risk in Framingham Offspring Study (P08-128-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Mengjie Yuan ◽  
R Taylor Pickering ◽  
Martha Singer ◽  
Lynn Moore
Keyword(s):  
Particle Size ◽  
Fatty Acid ◽  
Dietary Fat ◽  
Cox Proportional Hazards ◽  
Particle Sizes ◽  
Food Groups ◽  
Linear Regression Models ◽  
Cvd Risk ◽  
Ldl Particle Size ◽  
Ldl Particles

Abstract Objectives Small dense LDL particles have been shown to promote atherogenic cardiovascular disease (CVD). Dietary fat type may impact LDL particle size, but few studies have examined the association between fatty acid intake and LDL particle size and CVD risk. Our goal was to examine the association of saturated fatty acid (SFA) intake with LDL particle size and CVD risk in subjects in the Framingham Offspring Study (FOS). Methods LDL particle profiles were measured by NMR spectroscopic assay during exam visit 4 in the prospective FOS. Dietary fat, carbohydrate and food groups were assessed using 3-day diet records at exams 3 and 5; intakes were adjusted for body weight using the residuals from linear regression models. Multivariable Cox proportional hazards models and generalized linear modeling (GLM) were used to adjust for sex, age, height, pack-years of smoking, fruit and non-starchy vegetable intakes, dairy, LDL particle size, and prevalent hypertension. Results Subjects were classified into 6 categories using the combined intakes of carbohydrates (<48% vs. ≥48% of calories) and weight-adjusted SFA (<20, 20-<30, ≥30 g/day). Among those with higher carbohydrate intake, increasing levels of dietary SFA were associated with reduced risk of CVD. Specifically, those with the highest SFA intake and higher energy-adjusted carbohydrate intakes had a 56% (CI: 0.24–0.82) lower risk of CVD compared with those who had both low SFA and lower carbohydrate intakes. Moreover, increasing SFA intake among those with higher carbohydrate intakes was also associated with larger LDL particle sizes (P = 0.04, highest SFA intake vs. lowest SFA intake). Among low-carbohydrate consumers, SFA intake was not associated with risk of CVD, but was still positively associated with larger LDL particle size (P = 0.0003, highest SFA intake vs. lowest SFA intake). Conclusions SFA intake was associated with larger LDL particle sizes regardless of carbohydrate intakes. However, a higher SFA intake was only associated with reduced CVD risk among those with higher carbohydrate intakes. Funding Sources National Dairy Council.

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