scholarly journals The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases

2020 ◽  
Vol 34 (5) ◽  
Author(s):  
Zhenluo Jiang ◽  
Shuwei Wang ◽  
Jiancheng Jin ◽  
Sheng Ying ◽  
Zhigang Chen ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Clinical Significance ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

scholarly journals Serum ischemic modified albumin (IMA) concentration and IMA/albumin ratio in patients with hepatitis B-related chronic liver diseases

2017 ◽  
Vol 47 ◽  
pp. 947-953 ◽  
Author(s):  
Fatma YAVUZ ◽  
Murat BIYIK ◽  
Mehmet ASIL ◽  
Ramazan DERTLİ ◽  
Ali DEMİR ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Albumin Ratio

scholarly journals Micro-RNAs in hepatitis B virus-related chronic liver diseases and hepatocellular carcinoma

2018 ◽  
Vol 10 (9) ◽  
pp. 558-570 ◽  
Author(s):  
Evangelista Sagnelli ◽  
Nicoletta Potenza ◽  
Lorenzo Onorato ◽  
Caterina Sagnelli ◽  
Nicola Coppola ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Micro Rnas ◽  
B Virus

scholarly journals Depressive symptoms and cognitive dysfunctions in patients with chronic hepatitis B

2015 ◽  
Vol 143 (1-2) ◽  
pp. 6-11 ◽  
Author(s):  
Sladjana Pavic ◽  
Neda Svirtlih ◽  
Dragan Delic ◽  
Aleksandra Radovanovic-Spurnic
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cognitive Dysfunction ◽  
Cognitive Functions ◽  
Liver Diseases ◽  
Cognitive Disorders ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Healthy Persons

Introduction. Pronounced symptoms of depression and disorders of cognitive functions can be observed in patients with chronic hepatitis B. Objective. The objective of the study was evaluation of the severity of symptoms and predictive factors for depression and the existence of cognitive disorders in patients with chronic hepatitis B. Methods. A total of 150 respondents were included in this prospective study (50 patients with chronic hepatitis B, 50 patients with other chronic liver diseases and 50 healthy persons). The patients with chronic hepatitis B were homogeneous by age compared to healthy subjects (p=0.566) and patients with other chronic liver diseases (p=0.528). Assessment of intensity of depression was determined by the Hamilton Depression Rating Scale (HAMD). A Mini Mental State Examination (MMSE) test was used to investigate the presence of cognitive disorders. Results. Significantly expressed depression was observed in patients with chronic hepatitis B compared with healthy persons as well as the occurrence of cognitive dysfunction (p=0.00), while in comparison with the patients with chronic nonviral liver diseases, depression was statistically significantly less markedly expressed (p=0.003). Depression and cognitive dysfunction were more noticeable in patients with chronic hepatitis B in the stage of liver cirrhosis in relation to the early stage of the disease. Multivariate analysis of variables related to the sociodemographic characteristics showed that the most significant positive predictor of depression was more expressed in older age (over 50 years) (B=0.276; SE=0.092; p=0.004). Conclusion. Patients with chronic hepatitis B have a higher intensity of depression compared to healthy people, which is intensified with the progression of the disease. The highest expression of depression is expected in the elderly. Patients with chronic hepatitis B have a lower intensity of depression and fewer disorders of cognitive functions than patients with other chronic liver diseases.

The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review

2017 ◽  
Vol 54 (2) ◽  
pp. 282-294 ◽  
Author(s):  
Mingjie Yao ◽  
Leijie Wang ◽  
Patrick S. C. Leung ◽  
Yanmei Li ◽  
Shuhong Liu ◽  
...  
Keyword(s):  
Experimental Data ◽  
Literature Review ◽  
Clinical Significance ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

The Impact of p53 Mutations on the Course of Hepatitis B or C-related Chronic Liver Diseases in Taiwan

2009 ◽  
Vol 104 ◽  
pp. S148
Author(s):  
Yone-Han Mah ◽  
Ching-Sheng Hsu ◽  
Chen-Hua Liu ◽  
Chun-Jen Liu ◽  
Ming-Yang Lai ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Liver Diseases ◽  
Chronic Liver ◽  
P53 Mutations ◽  
Chronic Liver Diseases ◽  
The Impact

scholarly journals Prevalence and Clinical Significance of Immunoglobulin A Antibodies against Tissue Transglutaminase in Patients with Diverse Chronic Liver Diseases

2005 ◽  
Vol 12 (8) ◽  
pp. 941-948 ◽  
Author(s):  
Anastasios E. Germenis ◽  
Efthalia E. Yiannaki ◽  
Kalliopi Zachou ◽  
Violeta Roka ◽  
Sotirios Barbanis ◽  
...  
Keyword(s):  
Liver Disease ◽  
Clinical Significance ◽  
Liver Diseases ◽  
Tissue Transglutaminase ◽  
Immunoglobulin A ◽  
Chronic Liver ◽  
Intestinal Biopsy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Chronic Liver Diseases ◽  
Hla Dq

ABSTRACT The prevalence of celiac disease (CD) and the prevalence and clinical significance of anti-tissue transglutaminase (tTG) antibodies (tTGAbs) in a large series of patients with chronic liver diseases were assessed. We studied 738 patients (462 with chronic viral hepatitis, 117 with autoimmune liver diseases, 113 with alcoholic or nonalcoholic fatty liver disease, and 46 with other liver disorders) and 1,350 healthy controls (HC). Immunoglobulin A (IgA) tTGAbs were measured by enzyme-linked immunosorbent assay and a microsphere-based flow cytometric assay. Positive sera were investigated for IgA antiendomysial antibodies (EmA). IgA tTGAb-positive subjects were invited to undergo a small-intestinal biopsy and HLA-DQ allele typing. Four of 1,350 HC (0.3%) tested tTGAb+ EmA+ and underwent a biopsy (CD confirmation in all). Four of 738 liver disease patients tested tTGAbs+ EmA+ (0.54%; not statistically significant). Two were HCV infected (1.24%; not statistically significant), and two had transaminasemia of unknown origin. Forty-three patients tested tTGAbs+ EmA− (5.8%; P < 0.001 compared to HC). Inhibition experiments verified the existence of specific IgA anti-tTG reactivity. Twenty-six of 43 patients underwent a biopsy (all negative for CD). Binary logistic regression analysis revealed age (P = 0.008), cirrhosis (P = 0.004), alkaline phosphatase (P = 0.026), and antinuclear antibodies (P = 0.012) as independent risk factors for tTGAb reactivity among the patients. It was concluded that CD prevalence is the same in HC and patients with chronic liver diseases. The prevalence of tTGAbs is higher in hepatic patients compared to HC, but their specificity for CD diagnosis in this group of patients is low. tTGAbs in patients appear to be associated with the presence of autoimmunity, cirrhosis, and cholestasis, irrespective of the origin of the liver disease.

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