scholarly journals Analysis of genotype distribution of thalassemia and G6PD deficiency among Hakka population in Meizhou city of Guangdong Province

2019 ◽  
Vol 34 (4) ◽  
Author(s):  
Heming Wu ◽  
Qiuyan Zhu ◽  
Hua Zhong ◽  
Zhikang Yu ◽  
Qunji Zhang ◽  
...  
Keyword(s):  
G6pd Deficiency ◽  
Guangdong Province ◽  
Genotype Distribution ◽  
Meizhou City

The gene spectrum of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Guangdong province, China

Gene ◽  
2018 ◽  
Vol 678 ◽  
pp. 312-317 ◽  
Author(s):  
Fen Lin ◽  
Zhao-Yun Lou ◽  
Shao-Yi Xing ◽  
Lin Zhang ◽  
Li-Ye Yang
Keyword(s):  
G6pd Deficiency ◽  
Guangdong Province ◽  
Glucose 6 Phosphate Dehydrogenase

Mechanism and Technics to Produce Geographical Indication Products of Chinese Blue-and-White Porcelain

2018 ◽  
Vol 281 ◽  
pp. 952-958 ◽  
Author(s):  
Gang Qin Shao ◽  
Xiao Bin Zhong ◽  
Yong Zhang ◽  
Xin Yi Feng ◽  
Can Zhu ◽  
...  
Keyword(s):  
Traditional Culture ◽  
Guangdong Province ◽  
Geographical Indication ◽  
High Quality ◽  
Local Resources ◽  
Meizhou City ◽  
White Porcelain

For over 1400 years, Dapu county, under the jurisdiction of Meizhou city, Guangdong province, one cradleland of the Hakka traditional culture, is renowned for the blue and white porcelain in China. In this work, the mechanism and technics to produce Dapu geographical indication products of blue-and-white porcelains with high quality were studied, based on the distinct characteristics of local resources.

scholarly journals Distribution of G6PD deficiency genotypes among Southeast Asian populations

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Indah S. Tantular ◽  
Fumihiko Kawamoto
Keyword(s):  
G6pd Deficiency ◽  
Genetic Disorders ◽  
Epidemiological Studies ◽  
Southeast Asian ◽  
Genotype Distribution ◽  
Asian Countries ◽  
Asian Populations ◽  
Functional Variants ◽  
G6pd Gene ◽  
Glucose 6 Phosphate Dehydrogenase

AbstractGlucose-6-phosphate dehydrogenase (G6PD) deficiency is a group of X-linked, hereditary genetic disorders caused by mutations in the G6PD gene and results in functional variants of about 400 biochemical and clinical phenotypes. Among them, more than 215 genotypes have been identified so far. In this review, specific features of the genotype distribution in different communities and countries are discussed based on multiple reports and our molecular epidemiological studies of Southeast Asian countries. Particularly, in Indonesia, the frequency distribution of G6PD deficiency variants was distinct between western and eastern Indonesian populations, suggesting two different gene flows during Indonesian expansions.

Evaluation of the Diagnostic Accuracy of the CareStart™ Glucose-6-Phosphate Dehydrogenase Deficiency Rapid Diagnostic Test among Chinese Newborns

2020 ◽  
Vol 66 (5) ◽  
pp. 495-503 ◽  
Author(s):  
Fengting Yu ◽  
Sufen Zhang ◽  
Binhuan Chen ◽  
Yuqiu Zhou ◽  
Chengjie Ma ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Diagnostic Accuracy ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
G6pd Deficiency ◽  
Quantitative Detection ◽  
Study Cohort ◽  
Genotype Distribution ◽  
Residual Enzyme Activity ◽  
Cutoff Value

Abstract Previous studies have shown that the CareStart™ G6PD Deficiency rapid diagnostic test has high diagnostic accuracy on G6PD deficiency in Africa and Thailand, but not in China. As there are regional differences of G6PD genotype distribution, we are attending to verify the effectiveness of the kit in Chinese population. The study cohort included 247 newborns admitted to our hospital for jaundice. The quantitative detection of G6PD enzyme activity and G6PD gene mutations analysis was used to classify the status of G6PD deficiency. The performance of CareStart™ assays was verified by calculating the sensitivity, specificity and area under the receiver operating characteristic curve (AUC) based on the corrected G6PD deficiency status. In male newborns, the sensitivity of the CareStart™ assay was 98.9%, the specificity was 94.2% and the AUC was 0.97. In female newborns, the sensitivity was 58.5% when the cutoff value of residual enzyme activity was 100%; however, the sensitivity was 100% when the cutoff value was 60%. Therefore, the CareStart™ test can effectively screen G6PD deficiency in male newborns and female infants with less than 60% residual enzyme activity, female infants with residual enzyme activities of 60–100% are more likely to be missed diagnosed among Chinese newborns.

PCR-RFLP Detection od PAI-2 Gene Variants: Prevelence in Ethnic Groups and Disease Relationship in patients Undergoing corony Angiography

1997 ◽  
Vol 77 (05) ◽  
pp. 0955-0958 ◽  
Author(s):  
Carole A Foy ◽  
Peter J Grant
Keyword(s):  
Gene Variants ◽  
Genotype Distribution ◽  
Pima Indians ◽  
Significant Difference ◽  
Pcr Rflp ◽  
History Of ◽  
Caucasian Patients ◽  
Clinical Conditions ◽  
Rflp Assay ◽  
Coronary Atheroma

SummaryPAI-2 is a fibrinolytic inhibitor produced predominantly by monocytes. Most PAI-2 is intracellular making study in clinical conditions difficult. Abnormalities in production may be associated with inflammation and fibrinolysis at sites of tissue damage such as the atherosclerotic plaque.PAI-2 gene variants have been described: variant A consists of Asn120, Asn404 and Ser413 and variant B consists of Asp120, Lys404 and Cys413. We designed a PCR-RFLP assay using primers spanning the region containing Asn/Lys404 and Ser/Cys413. Variant B contains an Mwol restriction site. We analysed 302 Pima Indians and 286 healthy Caucasian volunteers. To investigate relationships between genotype and vascular disease we analysed 333 Caucasian patients undergoing coronary angiography.Gene variant B was more common in the Pimas than in Caucasians (p <0.0001). There was no significant difference in genotype distribution between the volunteers and patients. In the patients there was no association between genotype and either a history of MI or extent of coronary atheroma.

Benefits of the Tram System in Zhuhai, Guangdong Province, China

ICTE 2015 ◽  
2015 ◽  
Author(s):  
Lin Hong ◽  
Ying Jiang ◽  
Yaqian Li ◽  
Zekai Xu ◽  
Fan Li ◽  
...  
Keyword(s):  
Guangdong Province
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