scholarly journals Association between serum levels of bone turnover markers and bone mineral density in men and women with type 2 diabetes mellitus

2019 ◽  
Vol 34 (4) ◽  
Author(s):  
Chenhe Zhao ◽  
Guangwang Liu ◽  
Yao Zhang ◽  
Guiping Xu ◽  
Xilu Yi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Turnover ◽  
Serum Levels ◽  
Mineral Density ◽  
Men And Women ◽  
Turnover Markers

Trabecular Bone Score in Thais with or without Type 2 Diabetes

2020 ◽  
Vol 103 (11) ◽  
pp. 1131-1137
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fracture Risk ◽  
Trabecular Bone ◽  
Trabecular Bone Score ◽  
Mineral Density ◽  
Men And Women

Background: When compared to people without type 2 diabetes mellitus (T2DM), people with T2DM have an increase in fracture risk despite having higher bone mineral density (BMD). Many studies in Caucasians demonstrated that trabecular bone score (TBS) is lower in people with T2DM than those without. The utility of TBS as a fracture risk assessment tool in Asians with T2DM is currently unclear. Objective: To compared lumbar spine (LS) BMD and TBS in Thais with or without T2DM and investigate the correlation between TBS and hemoglobin A1c (HbA1c) and diabetes duration in participants with T2DM. Materials and Methods: The present study was a cross-sectional study that included 97 participants with T2DM (37 men and 60 women) and 342 participants without T2DM (174 men and 168 women). LS-BMD and TBS were obtained. Results: Men and women with T2DM were older and had higher body mass index (BMI). Men with T2DM had significant higher LS-BMD (1.051±0.166 versus 0.972±0.125, p=0.009) and non-significant lower TBS (1.333±0.084 versus 1.365±0.096, p=0.055) than those without. Similarly, women with T2DM had significant higher LS-BMD (0.995±0.155 versus 0.949±0.124, p=0.021) and lower TBS (1.292±0.105 versus 1.382±0.096, p<0.001). After adjusting for age and BMI, T2DM predicted higher BMD in men (p<0.001), but not in women (p=0.143). T2DM was not associated with TBS after adjusting for age and BMI in both genders (p=0.403 and p=0.151 in men and women, respectively). TBS did not correlate with HbA1c in both genders. However, TBS was non-significantly associated with diabetes duration in women (p=0.073), but not in men (p=0.639). Conclusion: T2DM significantly predicted higher LS-BMD only in men and was not independently associated with TBS in both genders. These data highlighted that, in T2DM, there was some variation in the clinical usefulness of BMD and TBS in predicting osteoporotic fractures with regard to clinical characteristic of participants. Keywords: Bone mineral density, Type 2 diabetes mellitus, Trabecular bone score

scholarly journals Hemoglobin A1c of 7% is the Threshold For Bone Impairment in Men With Type 2 Diabetes Mellitus

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A276-A276
Author(s):  
Sabaa Salim Joad ◽  
Giulia Gregori ◽  
Vittoria Russo ◽  
Lina E Aguirre ◽  
Georgia Colleluori ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liquid Chromatography ◽  
Bone Turnover ◽  
Hemoglobin A1c ◽  
Mineral Density ◽  
Group 4

Abstract Background: Emerging data suggest that type 2 diabetes mellitus (T2DM) is associated with increased risk for fractures despite relatively normal or increased bone mineral density (BMD). Furthermore, it is now known that decreased bone turnover mainly due to reduced bone formation is the hallmark for bone disease in T2DM. Whether glucose control is important in generating this impairment in bone metabolism remains unknown and to what extent it would reflect this abnormality is undetermined. The purpose of our study is to identify Hemoglobin A1c (A1c) level threshold by which reduction in bone turnover begins. Method: Baseline data from 217 men between age of 35–65 who were participants in 2 clinical trials conducted at the Michael DeBakey VA Medical Center and the New Mexico VA Health Care System were analyzed. A1c was measured by high performance liquid chromatography, testosterone and estradiol measured by liquid chromatography/mass spectrometry (LC/MS). Bone turnover markers (Osteocalcin [OC],C-telopeptide of type 1 Collagen [CTx]) and sclerostin were measured by enzyme-linked immunosorbent assay. Bone mineral density was assessed by dual energy X-ray absorptiometry. Patients were grouped into 4 categories based of A1c values (%) (group 1:&lt;6, group 2:6.1–6.5, group 3: 6.6–7 and group 4: &gt;7). Simple correlations were assessed by simple regression analysis and group comparisons among the different A1c categories were performed by analysis of variance (ANOVA). Results: The mean age of the participants was 55±9 years old with mean BMI of 36.15±6.44 kg/m2. Participants mean A1c was 6.1±1.5%. Simple correlation analysis showed a significant negative correlation between A1C and OC (r=-0.32, p&lt;0.001) and CTx (r=-0.32, p&lt;0.001). Comparison of bone turn over markers among different A1c groups revealed significantly lower OC in group 4 (A1C&gt;7%), compared to groups with A1Cs ≤7%, i.e. 1, 2 and 3 (4.04 ± 2.64 vs 6.53 ± 3.18, 5.99 ± 3.16 and 6.09 ± 3.16 ng/mL, respectively, p = 0.002). Similarly, CTx was lower in group 4 compared to groups 1, 2, and 3 (0.19 ± 0.12 ng/mL vs 0.34 ± 0.17, 0.32 ± 0.18 and 0.28 ± 0.14 ng/mL, respectively, p=0.0002). Sclerostin levels were comparable among all the A1c categories. Analysis of the subgroup of men with T2DM (n=71) again showed lower OC (3.95 ± 2.68 vs. 6.34 ± 2.77, p=0.007) and CTx (0.18 ± 0.13 vs. 0.31 ± 0.15, p&lt;0.001) in those with A1c &gt;7% compared to those ≤7%, respectively. The significance between the groups persisted even after adjusting for medications, p=0.003. Analysis adjusted for baseline age, weight and testosterone showed no significant difference in areal BMD at all sites in the general population and in the subset of men with T2DM according to A1C categories. Conclusion: Our data analysis showed breakpoint A1c level of 7% or greater is associated with lower bone turnover irrespective of medication use in patients with T2DM.

scholarly journals Rosiglitazone Decreases Bone Mineral Density and Increases Bone Turnover in Postmenopausal Women With Type 2 Diabetes Mellitus

2013 ◽  
Vol 98 (4) ◽  
pp. 1519-1528 ◽  
Author(s):  
John P. Bilezikian ◽  
Robert G. Josse ◽  
Richard Eastell ◽  
E. Michael Lewiecki ◽  
Colin G. Miller ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density

Bone mineral density in male patients with type 2 diabetes mellitus, with and without hypogonadism

2017 ◽  
Author(s):  
Agathi Vasileiou ◽  
Ioanna Karathanassi ◽  
Parthena Navrozidou ◽  
Marianna Vlychou ◽  
Georgios Koukoulis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Mineral ◽  
Mineral Density ◽  
Male Patients
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