scholarly journals Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio are associated with disease activity in polymyalgia rheumatica

2019 ◽  
Vol 33 (9) ◽  
Author(s):  
Ju‐Yang Jung ◽  
Eunyoung Lee ◽  
Chang‐Hee Suh ◽  
Hyoun‐Ah Kim
Keyword(s):  
Disease Activity ◽  
Polymyalgia Rheumatica ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Marker of Disease Activity in Rheumatoid Arthritis

2019 ◽  
Vol 87 (March) ◽  
pp. 139-145
Author(s):  
REHAB M. HELAL, M.Sc. MOHAMMED H. EL-NAGGAR, M.D.; ◽  
MOHAMED K. ZAHRA, M.D. NASHWA M. ABO EL-NASR, M.D.
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

Hematological Inflammatory Markers in Patients with Pemphigus Vulgaris

Dermatology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Anna Lyakhovitsky ◽  
Joel Dascalu ◽  
Theodoulos Drousiotis ◽  
Aviv Barzilai ◽  
Sharon Baum
Keyword(s):  
Disease Activity ◽  
Treatment Response ◽  
Mean Platelet Volume ◽  
Pemphigus Vulgaris ◽  
Neutrophil To Lymphocyte Ratio ◽  
Disease Stage ◽  
Platelet Volume ◽  
Platelet To Lymphocyte Ratio ◽  
Early Relapse ◽  
Lymphocyte Ratio

<b><i>Background:</i></b> Emerging evidence indicates that several hematological markers can be used to evaluate treatment response, prediction, and early relapse detection in different inflammatory conditions. This study aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, platelet-to-neutrophil ratio, mean platelet volume, and disease activity in patients with pemphigus vulgaris. <b><i>Methods:</i></b> Fifty-six patients (20 men, 36 women; mean age 54 ± 14 years) diagnosed with pemphigus vulgaris were included in this retrospective study. Patients were divided into those treated and not treated with rituximab (groups 1 and 2), and into those who did and did not develop relapse (groups 3 and 4). The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, platelet-to-neutrophil ratio and mean platelet volume were evaluated at the time of diagnosis, remission, and relapse. The relationship between each marker and disease stage was analyzed using the Wilcoxon rank-sum test for pairwise comparisons. <b><i>Results:</i></b> The neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio showed a positive correlation with disease activity, while the platelet-to-neutrophil ratio and mean platelet volume showed a negative correlation. The neutrophil-to-lymphocyte ratio significantly decreased in remission (<i>p</i> &#x3c; 0.001) and significantly increased in relapse (<i>p</i> &#x3c; 0.01). The platelet-to-lymphocyte ratio significantly decreased in remission (<i>p</i> &#x3c; 0.001) and showed no significant change in relapse. The platelet-to-neutrophil ratio significantly increased in remission (<i>p</i> &#x3c; 0.001) and significantly decreased at relapse (<i>p</i> &#x3c; 0.001). The mean platelet volume significantly increased in remission (<i>p</i> &#x3c; 0.001) and decreased non-significantly at relapse. A more significant decrease in the neutrophil-to-lymphocyte ratio in remission was found in patients not treated with rituximab. No significant differences were observed between patients who developed relapse and those who did not. <b><i>Conclusion:</i></b> Our results suggest that the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, platelet-to-neutrophil ratio, and mean platelet volume can be useful markers for monitoring treatment response, while the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio can also assist in detecting early relapse.

scholarly journals Neutrophil to Lymphocyte Ratio Predicts Glucocorticoid Resistance in Polymyalgia Rheumatica: A Prospective Study

2020 ◽  
Author(s):  
Claire Owen ◽  
Christopher McMaster ◽  
David FL Liew ◽  
Jessica L Leung ◽  
Andrew M Scott ◽  
...  
Keyword(s):  
Disease Activity ◽  
Polymyalgia Rheumatica ◽  
Linear Regression Analysis ◽  
Initial Response ◽  
Primary Outcome Measure ◽  
Neutrophil To Lymphocyte Ratio ◽  
Glucocorticoid Resistance ◽  
Newly Diagnosed ◽  
Lymphocyte Ratio ◽  
The Relationship

Abstract Background Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been found to correlate with disease activity in several rheumatic diseases, however their clinical and prognostic utility in polymyalgia rheumatica (PMR) remains unclear. This study evaluated the relationship between NLR and PLR, and disease activity and glucocorticoid resistance in PMR. Methods Data for disease activity (PMR-AS) and full blood examination was obtained from a prospective observational cohort comprising newly diagnosed (2012 EULAR/ACR classification criteria), steroid-naïve PMR patients treated with low-dose glucocorticoid therapy (BSR guideline). Glucocorticoid resistance was defined as non-response to initial prednisolone dose (15mg/day) or initial response followed by flare (PMR-AS ≥9.35 or ∆≥6.6) upon weaning prednisolone to 5mg/day. Univariable Bayesian linear regression analysis of the relationship between PMR-AS (baseline and mean) and NLR and PLR was performed. Predictors of glucocorticoid resistance were identified using a multivariable outcome model, with variables chosen based upon Bayesian model selection. Results Of the 32 included patients, 16 (50%) fulfilled the primary outcome measure of glucocorticoid resistance. These participants were older, typically female, and had higher baseline CRP than their glucocorticoid-responsive counterparts. A statistically significant relationship was identified between PMR-AS and both NLR (OR 28.1 [95% CI 1.6 – 54.7]) and PLR (OR 40.6 [95% CI 10.1 – 71.4]) at baseline, with PLR also found to correlate with disease activity during follow-up (OR 15.6 [95% CI 2.7 – 28.2]). Baseline NLR proved to be a statistically significant predictor of glucocorticoid-resistant PMR (OR 14.01 [95% CI 1.49 – 278.06]). Conclusion Baseline NLR can predict glucocorticoid resistance in newly diagnosed PMR patients. Both NLR and PLR may be reliable biomarkers of disease activity in PMR.

Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein to albumin ratio, and albumin to fibrinogen ratio in axial spondyloarthritis: a monocentric study

2020 ◽  
Vol 16 ◽  
Author(s):  
Maroua Slouma ◽  
Safa Rahmouni ◽  
Rim Dhahri ◽  
Imen Gharsallah ◽  
Leila Metoui ◽  
...  
Keyword(s):  
Disease Activity ◽  
Pearson Correlation ◽  
Neutrophil To Lymphocyte Ratio ◽  
High Disease Activity ◽  
C Reactive Protein ◽  
Platelet To Lymphocyte Ratio ◽  
Albumin Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Very High

Background: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are routinely used to assess disease activity in spondyloarthritis. New biomarkers have been reported, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), CRP to albumin ratio (CAR), and albumin to fibrinogen ratio (AFR). Our study aimed to assess these ratios in spondyloarthritis and to determine the relationship between these ratios and the disease activity. Methods: We conducted a cross-sectional study, including patients with spondyloarthritis. The following ratios were calculated: PLR, NLR, AFR, and CAR. Pearson correlation analysis was carried out to test the correlation of the data. Receiver operating characteristic curves were evaluated for each ratio using ASDASCRP as the gold standard for disease activity. Results: Eighty-five patients were included. The sex ratio was 60 males to 25 females. The mean age was 42.58 ± 11.75 years. There was a positive correlation between the PLR and the following parameters: CAR, CRP, and ESR. A negative correlation was found between AFR and the following ratios: PLR, NLR, CRP, and ESR. The ASDAS correlated negatively with AFR and positively with both PLR and CAR. The cut-offs values of CAR and PLR to distinguish patients with very high disease activity (ASDASCRP>3.5) were 0.442 and 173.64, respectively. Conclusions: Given their good correlation with ESR and CRP, we suggest that PLR, CAR, and AFR can be used as potential indicators of inflammation in spondyloarthritis. The CAR and PLR are useful to identify patients with very high disease activity.

Sign in / Sign up

Export Citation Format

Share Document