scholarly journals Association between subclinical hypothyroidism and metabolic disorders: A retrospective chart review study in an emerging university hospital

2019 ◽  
Vol 33 (9) ◽  
Author(s):  
Khaled Aldossari ◽  
Sameer Al‐Ghamdi ◽  
Jamaan Al‐Zahrani ◽  
Anwar Al Jammah ◽  
Bader Alanazi ◽  
...  
Keyword(s):  
Subclinical Hypothyroidism ◽  
Metabolic Disorders ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
Review Study

Abstract 17044: Gender Discrepancies in Management and Outcome of Hospitalized Heart Failure Patients

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Idris Bare ◽  
Rizwan Malik ◽  
Yangzhao Cheng ◽  
Prosanta Mondal ◽  
Jason Orvold ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
Clinical Factors ◽  
Academic Hospital ◽  
Review Study ◽  
Baseline Characteristics ◽  
Gender Discrepancies

Introduction: The incidence of heart failure (HF), particularly in women, is increasing rapidly. While earlier reports indicated that HF mortality was higher in men compared to women, recent studies have suggested higher HF mortality in women. The cause of this changing pattern is not well described. The purpose of this study was to explore different clinical factors and management patterns that could contribute to this. Methods: We conducted a retrospective chart review study of all the patients admitted to a tertiary academic hospital (Royal University Hospital, University of Saskatchewan, Canada) with a diagnosis of HF in 2015, with follow up analysis up to February 20, 2018. Results: In total, 379 patients were admitted with HF, of which 166 (43.8%) were women. Overall, the most important predictors of mortality on multivariate analysis include admission to non-cardiology services (NCS, p < 0.0001), age on admission (p<0.001), readmission (p=0.001), and haemoglobin on admission (P=0.004). Review of baseline characteristics showed that women with HF were older (p<0.001), and more likely to have HFpEF (26.3% vs. 46.4%, p<0.001) than men. However, women were less likely to have comorbidities including COPD, CKD, PVD, HTN, diabetes and dyslipidemia (p<0.001). In spite of this, there was a trend towards higher mortality among women over the follow up period (57.8% vs. 47.9%, p=0.055). Women were significantly less likely to be admitted to cardiology (62% vs. 71.4%, p=0.0084), and less likely to have follow up scheduled on discharge with either an internist or cardiologist (70.4% vs. 53.6%, p<0.001). Similar gender discrepancy in admission to cardiology was also observed among the subgroup of patients with HFrEF. Conclusions: In our study, women admitted with heart failure had worse overall prognosis than men, in spite of less associated comorbidities. Admission to cardiology service was the most significant positive prognostic factor overall. However, surprisingly, women were significantly less likely to be admitted to cardiology, possibly contributing to their observed poor outcome. Further studies to elucidate factors underlying this observed difference in admission pattern may help improve the management of women with HF.

Improving patient safety in Palestinian hospitals: a cross-sectional and retrospective chart review study

The Lancet ◽  
2018 ◽  
Vol 391 ◽  
pp. S44
Author(s):  
Shahenaz Najjar ◽  
Nashat Nafouri ◽  
Kris Vanhaecht ◽  
Martin Euwema
Keyword(s):  
Patient Safety ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Cross Sectional ◽  
Review Study

scholarly journals Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients—a retrospective chart review

2021 ◽  
Author(s):  
Azzeddine Kermad ◽  
Jacques Speltz ◽  
Guy Danziger ◽  
Thilo Mertke ◽  
Robert Bals ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Retrospective Study ◽  
Linear Regression ◽  
Chart Review ◽  
Distress Syndrome ◽  
Minute Ventilation ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
High Doses ◽  
End Tidal

Abstract Purpose In this retrospective study, we compared inhaled sedation with isoflurane to intravenous propofol in invasively ventilated COVID-19 patients with ARDS (Acute Respiratory Distress Syndrome). Methods Charts of all 20 patients with COVID-19 ARDS admitted to the ICU of a German University Hospital during the first wave of the pandemic between 22/03/2020 and 21/04/2020 were reviewed. Among screened 333 days, isoflurane was used in 97 days, while in 187 days, propofol was used for 12 h or more. The effect and dose of these two sedatives were compared. Mixed sedation days were excluded. Results Patients’ age (median [interquartile range]) was 64 (60–68) years. They were invasively ventilated for 36 [21–50] days. End-tidal isoflurane concentrations were high (0.96 ± 0.41 Vol %); multiple linear regression yielded the ratio (isoflurane infusion rate)/(minute ventilation) as the single best predictor. Infusion rates were decreased under ECMO (3.5 ± 1.4 versus 7.1 ± 3.2 ml∙h−1; p < 0.001). In five patients, the maximum recommended dose of propofol of 4 mg∙hour−1∙kg−1ABW was exceeded on several days. On isoflurane compared to propofol days, neuro-muscular blocking agents (NMBAs) were used less frequently (11% versus 21%; p < 0.05), as were co-sedatives (7% versus 31%, p < 0.001); daily opioid doses were lower (720 [720–960] versus 1080 [720–1620] mg morphine equivalents, p < 0.001); and RASS scores indicated deeper levels of sedation (− 4.0 [− 4.0 to − 3.0] versus − 3.0 [− 3.6 to − 2.5]; p < 0.01). Conclusion Isoflurane provided sufficient sedation with less NMBAs, less polypharmacy and lower opioid doses compared to propofol. High doses of both drugs were needed in severely ill COVID-19 patients.

scholarly journals Tuberous sclerosis complex: Clinical spectrum and epilepsy: A retrospective chart review study

2018 ◽  
Vol 9 (1) ◽  
pp. 154-160
Author(s):  
Sulaiman Almobarak ◽  
Mohammad Almuhaizea ◽  
Musaad Abukhaled ◽  
Suad Alyamani ◽  
Omar Dabbagh ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Gene Mutation ◽  
Tuberous Sclerosis Complex ◽  
Chart Review ◽  
Clinical Presentation ◽  
Retrospective Chart Review ◽  
Neurocutaneous Disorder ◽  
Development Delay ◽  
Review Study ◽  
New Onset

Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant genetic neurocutaneous disorder, with heterogeneous manifestations. We aimed to review the clinical presentation of TSC and its association with epilepsy among Saudi population. This was a retrospective chart review study of 88 patients diagnosed with TSC with or without epilepsy. In 38.6% of patients, symptoms began before 1 year of age. The most frequent initial manifestations of TSC were new onset of seizures (68.2%), skin manifestations (46.6%) and development delay (23.9%). During the evolution of the disease 65.9% had epilepsy, 17% facial angiofibromas, 13.6% Shagreen patch, 18.2% heart rhabdomyomas and 12.5% retinal hamartomas. The genetic study for TSC diagnosis was done for 44 patients, 42 (95,4%) of them were genetically confirmed, for whom 13 patients had TSC1 mutation (29.5%), 29 patients were carrying TSC2 gene mutation (65.9%), Genetic test for TSC 1 and TSC 2 were negative for 2 patients (4.5%) despite positive gene mutation in their relative with TSC. The most common manifestations were central nervous system (predominantly epilepsy) and dermatological manifestations. Most of the patients develop epilepsy with multiple seizure types. TSC 2 mutation is more common than TSC 1 mutation.

scholarly journals Post-operative fever in children undergoing mastoidectomy due to complicated acute mastoiditis

2021 ◽  
Author(s):  
Oren Ziv ◽  
Aviad Sapir ◽  
Eugene Leibowitz ◽  
Sofia Kordeluk ◽  
Daniel KAPLAN ◽  
...  
Keyword(s):  
Chart Review ◽  
Tertiary Care ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
Acute Mastoiditis ◽  
Benign Condition ◽  
Subperiosteal Abscess ◽  
Cortical Mastoidectomy ◽  
New Findings ◽  
Mastoid Surgery

Abstract Objectives: To determine the immediate post-operative course and outcome of pediatric patients with complicated acute mastoiditis (CAM) following surgical treatment. Study Design: A retrospective chart review of children diagnosed with CAM who underwent mastoid surgery during 2012-2019. Setting: Tertiary care university hospital. Participants: the study includes 33 patients, divided into two groups: 17 patients with subperiosteal abscess (SPA) alone - single complication group (SCG) and 16 patients with SPA and additional intracranial or intratemporal complications -multiple complications group (MCG). Main Outcome Measures: post-operative fever course and pattern (POF). Results :33 patients belong to the SCG 17(51%) and 16(49%) belonged to the MCG, respectively. 6/17(35.3%) SCG patients experienced POF vs. 12/16(75%) in the MCG (P=0.012). At post-operative day 2 (POD2), 10/13(77%) febrile patients belonged to MCG and 3/13(23%) to SCG (P=0.013). POF was recorded until POD6 in both groups. Seven patients, all from MCG with POF, underwent second imaging with no new findings. Conclusion: Following a cortical mastoidectomy for CAM, POF is not unusual in the first 6 days and seem to be benign condition. POF is more common, higher, and persistent for a longer duration in MCG compared with SCG. At POD 6, fever is expected to normalize in both groups, so if fever persists further evaluation should be considered.

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