scholarly journals Association of peripheral blood neutrophil gelatinase‐associated lipocalin levels with bone marrow neutrophil gelatinase‐associated lipocalin levels and neutrophil count in hematologic malignancy

2019 ◽  
Vol 33 (6) ◽  
Author(s):  
Chi‐Hyun Cho ◽  
Jung Yoon ◽  
Deok‐Su Kim ◽  
Shin‐Jong Kim ◽  
Hwa Jung Sung ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Neutrophil Count ◽  
Peripheral Blood ◽  
Hematologic Malignancy ◽  
Blood Neutrophil ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Peripheral Blood Neutrophil ◽  
Neutrophil Gelatinase

scholarly journals Preoperative peripheral blood neutrophil count predicts long-term outcomes following hepatic resection for colorectal liver metastases

2017 ◽  
Vol 13 (5) ◽  
pp. 3688-3694 ◽  
Author(s):  
Koichiro Haruki ◽  
Hiroaki Shiba ◽  
Yuki Fujiwara ◽  
Kenei Furukawa ◽  
Tomonori Iida ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Hepatic Resection ◽  
Neutrophil Count ◽  
Peripheral Blood ◽  
Colorectal Liver Metastases ◽  
Blood Neutrophil ◽  
Long Term Outcomes ◽  
Peripheral Blood Neutrophil

scholarly journals Quantitative in vivo assay of human granulocyte colony-stimulating factor using cyclophosphamide-induced neutropenic mice

Blood ◽  
1990 ◽  
Vol 75 (6) ◽  
pp. 1228-1233 ◽  
Author(s):  
K Hattori ◽  
K Shimizu ◽  
M Takahashi ◽  
M Tamura ◽  
M Oheda ◽  
...  
Keyword(s):  
Linear Relationship ◽  
Neutrophil Count ◽  
Peripheral Blood ◽  
Assay Method ◽  
Blood Neutrophil ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Peripheral Blood Neutrophil ◽  
Stimulating Factor

Abstract Administration of human granulocyte colony-stimulating factor (hG-CSF) to mice with cyclophosphamide (CPA)-induced neutropenia for 4 consecutive days from the day after the CPA dosing (100 mg/kg) resulted in a dose-dependent increase in the peripheral blood neutrophil count 6 hours after the final hG-CSF injection. Within the hG-CSF dose range of 0.1 to 10 micrograms per mouse per day, there was a strong linear relationship (r greater than .9) between the logarithm of the dose and the peripheral blood neutrophil count in the treated mice. Using the same hG-CSF preparation, 38 experiments indicated that the regression lines are highly reproducible. Such an association never occurred with intact mice, and 100 mg/kg of CPA induced the highest response to hG- CSF. This linear relationship between the two variables allows us to determine the biologic potency of a test hG-CSF preparation relative to a reference standard using a parallel line assay, with a coefficient of precision of around .2. When assayed by this bioassay procedure, which we have termed CPA-mouse assay, natural hG-CSF and recombinant hG-CSF (produced by Chinese hamster ovary cells) were nearly equipotent in specific biologic activity. These results confirm the CPA-mouse assay as an especially useful assay method for quantifying the in vivo activity of hG-CSF.

Peripheral blood neutrophil morphology reflects bone marrow dysplasia in myelodysplastic syndromes

1995 ◽  
Vol 49 (2) ◽  
pp. 115-120 ◽  
Author(s):  
S. Widell ◽  
E. Hellström-Lindberg ◽  
Y. Kock ◽  
M. Lindberg ◽  
Å. Öst ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Myelodysplastic Syndromes ◽  
Peripheral Blood ◽  
Blood Neutrophil ◽  
Peripheral Blood Neutrophil ◽  
Bone Marrow Dysplasia

scholarly journals Quantitative in vivo assay of human granulocyte colony-stimulating factor using cyclophosphamide-induced neutropenic mice

Blood ◽  
1990 ◽  
Vol 75 (6) ◽  
pp. 1228-1233
Author(s):  
K Hattori ◽  
K Shimizu ◽  
M Takahashi ◽  
M Tamura ◽  
M Oheda ◽  
...  
Keyword(s):  
Linear Relationship ◽  
Neutrophil Count ◽  
Peripheral Blood ◽  
Assay Method ◽  
Blood Neutrophil ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Peripheral Blood Neutrophil ◽  
Stimulating Factor

Administration of human granulocyte colony-stimulating factor (hG-CSF) to mice with cyclophosphamide (CPA)-induced neutropenia for 4 consecutive days from the day after the CPA dosing (100 mg/kg) resulted in a dose-dependent increase in the peripheral blood neutrophil count 6 hours after the final hG-CSF injection. Within the hG-CSF dose range of 0.1 to 10 micrograms per mouse per day, there was a strong linear relationship (r greater than .9) between the logarithm of the dose and the peripheral blood neutrophil count in the treated mice. Using the same hG-CSF preparation, 38 experiments indicated that the regression lines are highly reproducible. Such an association never occurred with intact mice, and 100 mg/kg of CPA induced the highest response to hG- CSF. This linear relationship between the two variables allows us to determine the biologic potency of a test hG-CSF preparation relative to a reference standard using a parallel line assay, with a coefficient of precision of around .2. When assayed by this bioassay procedure, which we have termed CPA-mouse assay, natural hG-CSF and recombinant hG-CSF (produced by Chinese hamster ovary cells) were nearly equipotent in specific biologic activity. These results confirm the CPA-mouse assay as an especially useful assay method for quantifying the in vivo activity of hG-CSF.

Sputum neutrophil count after bronchial allergen challenge is related to peripheral blood neutrophil chemotaxis in asthma patients

2014 ◽  
Vol 63 (11) ◽  
pp. 951-959 ◽  
Author(s):  
Simona Lavinskiene ◽  
Ieva Bajoriuniene ◽  
Kestutis Malakauskas ◽  
Jolanta Jeroch ◽  
Raimundas Sakalauskas
Keyword(s):  
Neutrophil Count ◽  
Peripheral Blood ◽  
Allergen Challenge ◽  
Neutrophil Chemotaxis ◽  
Blood Neutrophil ◽  
Peripheral Blood Neutrophil ◽  
Asthma Patients ◽  
Bronchial Allergen Challenge
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