scholarly journals Leucocyte telomere length and paroxysmal atrial fibrillation: A prospective cohort study and systematic review with meta‐analysis

2018 ◽  
Vol 32 (9) ◽  
Author(s):  
Nixiao Zhang ◽  
Chong Fan ◽  
Mengqi Gong ◽  
Xue Liang ◽  
Weili Zhang ◽  
...  
2017 ◽  
Vol 177 (4) ◽  
pp. 347-359 ◽  
Author(s):  
Samer R Khan ◽  
Arjola Bano ◽  
Marlies Wakkee ◽  
Tim I M Korevaar ◽  
Oscar H Franco ◽  
...  

ObjectiveAutoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results.DesignWe assessed the association of AITD with psoriatic disease in a prospective cohort study and performed a systematic review and meta-analysis.Methods8214 participants of the Rotterdam Study (RS) with thyroid peroxidase antibodies (TPO-Abs), thyroid-stimulating hormone (TSH) and/or free thyroxine (FT4) measurements and information on psoriatic disease were included. We performed logistic and Cox regression analyses and a systematic literature search in several electronic databases on AITD and psoriatic disease. We pooled odds ratios (ORs) of included studies using the Mantel-Haenszel method, while adding RS data on prevalent psoriatic disease.ResultsWithin the RS, we found no association between TPO-Ab positivity and psoriatic disease. There was a positive trend between TSH and prevalent psoriatic disease, and between FT4 and incident psoriatic disease, although not significant. Out of 1850 articles identified, seven were included in the systematic review and four in the meta-analysis. The risk of psoriatic disease (pooled OR) was 1.71 (confidence interval (CI): 1.27–2.31) for TPO-Ab positivity, 1.25 (CI: 1.14–1.37) for AITD and 1.34 (CI: 1.16–1.54) respectively, and 1.17 (CI: 1.03–1.32) for hypothyroidism and hyperthyroidism.ConclusionsOur meta-analysis suggests that TPO-Ab positivity, hypothyroidism and hyperthyroidism might be associated with prevalent psoriatic disease. However, there are only few studies with large heterogeneity regarding psoriatic disease definition and indication of publication bias. Additional prospective data are needed to assess the association of AITD with incident psoriatic disease.


PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112483 ◽  
Author(s):  
Peter Willeit ◽  
Julia Raschenberger ◽  
Emma E. Heydon ◽  
Sotirios Tsimikas ◽  
Margot Haun ◽  
...  

2016 ◽  
Vol 46 (2) ◽  
pp. 160-167 ◽  
Author(s):  
Nicola Veronese ◽  
Emanuele Cereda ◽  
Stefania Maggi ◽  
Claudio Luchini ◽  
Marco Solmi ◽  
...  

Radiology ◽  
2015 ◽  
Vol 277 (1) ◽  
pp. 173-180 ◽  
Author(s):  
Augustin Lecler ◽  
Jean Raymond ◽  
Christine Rodriguez-Régent ◽  
Fawaz Al Shareef ◽  
Denis Trystram ◽  
...  

2013 ◽  
Vol 41 (6) ◽  
pp. 610-620 ◽  
Author(s):  
S. C. Hillman ◽  
D. J. McMullan ◽  
G. Hall ◽  
F. S. Togneri ◽  
N. James ◽  
...  

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110143
Author(s):  
Fusheng Ke ◽  
Yinhui Huang ◽  
Zhexiu Jin ◽  
Lei Huang ◽  
Qiang Xiong ◽  
...  

Objective The present study aimed to investigate the effect of functional mitral regurgitation (FMR) on recurrence of paroxysmal atrial fibrillation (PAF) in patients undergoing radiofrequency catheter ablation. Methods This prospective cohort study comprised 107 patients with PAF. The patients were divided into the FMR and non-FMR groups. FMR was assessed by Doppler echocardiography before index ablation. All patients initially underwent circumferential pulmonary vein isolation (CPVI) and were followed up for 12 months after ablation. PAF, atrial tachycardia, or atrial flutter served as the endpoint indicator. Results The median duration of PAF was 24 (3–60) months. Binary logistic univariate and multivariate analyses showed that FMR was not a risk factor for recurrence of catheter ablation for PAF (hazard ratio=0.758, 95% confidence interval: 0.191–3.004; hazard ratio=0.665, 95% confidence interval: 0.134–3.300, respectively). Kaplan–Meier analysis showed no significant difference in the recurrence rate between the groups. Fifteen (15/107, 14%) cases of PAF were triggered by the pulmonary vein. Three (3/107, 2.8%) cases of PAF were triggered by the superior vena cava. Conclusions FMR is not an independent risk factor for predicting recurrence of catheter ablation for PAF. FMR does not affect patients undergoing radiofrequency catheter ablation for PAF.


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