scholarly journals Associations of urinary, glomerular, and tubular markers with the development of diabetic kidney disease in type 2 diabetes patients

2017 ◽  
Vol 32 (1) ◽  
pp. e22191 ◽  
Author(s):  
Xu Jiang ◽  
Qian Zhang ◽  
Hua-Bin Wang ◽  
Xiao-Fan Cui ◽  
Rui Liu
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Tubular Markers ◽  
Diabetes Patients

Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease

Endocrine ◽  
2016 ◽  
Vol 55 (1) ◽  
pp. 130-138 ◽  
Author(s):  
Ying Shao ◽  
Huiwen Ren ◽  
Chuan Lv ◽  
Xiaoyu Ma ◽  
Can Wu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Diabetes Patients

scholarly journals Manifestation of rs1888747 polymorphisms in the FRMD3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients

2021 ◽  
Author(s):  
Chatchai Kreepala ◽  
Pitirat Panpruang ◽  
Rapeeporn Yodprom ◽  
Teeraya Piyajarawong ◽  
Krittanont Wattanavaekin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
I Gene ◽  
Diabetes Patients

scholarly journals The Association of a Genetic Variant inSCAF8-CNKSR3with Diabetic Kidney Disease and Diabetic Retinopathy in a Chinese Population

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Li Jin ◽  
Tao Wang ◽  
Song Jiang ◽  
Miao Chen ◽  
Rong Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Mexican Americans ◽  
Diabetic Kidney Disease ◽  
Association Studies ◽  
Genome Wide Association Studies ◽  
Diabetic Kidney ◽  
Diabetes Patients

Background. Genome-wide association studies found rs955333 located in 6q25.2 was associated with diabetic kidney disease in multiple ethnic populations, including European Americans, African Americans, and Mexican Americans. We aimed to investigate the association between the variant rs955333 inSCAF8-CNKSR3and DKD susceptibility in Chinese type 2 diabetes patients.Methods. The variant rs955333 was genotyped in 1884 Chinese type 2 diabetes patients. Associations of the variant rs955333 with DKD and DR susceptibility and related quantitative traits were evaluated.Results. The variant rs955333 was not associated with DKD in our samples, while subjects with genotype GG were associated with DR (P=0.047, OR = 0.55250.308,0.9911), and it also showed association with microalbuminuria (P=0.024, beta = −0.1812-0.339,-0.024).Conclusion. Our data suggests the variant rs955333 was not associated with DKD but showed association with diabetic retinopathy in Chinese type 2 diabetes patients.

scholarly journals Association of Diabetic Kidney Disease Markers and Urinary Beta-crossLaps in Type 2 Diabetes

2021 ◽  
Author(s):  
Lalithambigai Arumugasamy ◽  
Hetal G Patel
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Patient Group ◽  
Diabetic Kidney Disease ◽  
Collagen Degradation ◽  
Statistical Testing ◽  
Creatinine Ratio ◽  
Diabetic Kidney ◽  
Diabetes Patients

Introduction: Diabetic Kidney Disease (DKD) is a chronic complication in Type 2 diabetes. The Chronic Kidney Disease (CKD273) peptide classifier has been found to predict development of DKD even before microalbuminuria develops. Seventy four percent of peptides in the CKD273 classifier are Collagen degradation fragments. The Beta-CrossLaps (β-CTx) Enzyme Llinked Immunosorbent Assay (ELISA) assay detects the specific collagen degradation product, C terminal telopeptide of Type 1 collagen. In light of the Capillary Electrophoresis/Mass Spectrometry (CE-MS) findings, linking collagen degradation fragments excretion to early detection of DKD, the significance of urinary β-CTx levels as a DKD biomarker needs to be evaluated. Aim: To study the urinary excretion of β-CTx in type 2 diabetes patients and to evaluate its relation to Microalbuminuria status and estimated Glomerular Filtration Rate (eGFR) of the patients. Materials and Methods: This descriptive cross-sectional study was undertaken at a tertiary care hospital, with enrollment of 82 type 2 diabetes patients from the diabetes Out Patient Department (OPD) Participants were divided into groups based on their Urinary Albumin Creatinine Ratio (UACR) and eGFR levels. The study participants were tested for Urinary β-CTx level, UACR and eGFR. Mean or median was calculated for the parameters with normal and non-normal distribution, respectively. All statistical testing was performed on online calculators available at the site; https://www.socscistatistics.com/. Results: The median urinary β-CTx level observed was 100.6 ng/mmol of creatinine. Among the 82 participants, 15 participants had urinary β-CTx level 15pg/mL, the sensitivity of the kit. Among the remaining 67 participants, the minimum Urinary Beta-CrossLaps: Creatinine ratio observed was 2.6 ng/mmol and the maximum value observed was 2071 ng/mmol (i.e., 2.1 μg/mmol). The median urinary β-CTx level was highest (100.6 ng/mmol creatinine) in the patient group with eGFR in the normal range. The urinary β-CTx level was found to decline with decline in eGFR, with median urinary β-CTx 65.5 ng/mmol creatinine in the patient group with mildly decreased eGFR and 7.2 ng/mmol creatinine in the patient group with moderately decreased eGFR. Conclusion: The Urinary β-CTx concentration in type 2 diabetes patients is dispersed over a wide range. The Urinary β-CTx concentration correlates with the eGFR of the patient and is not influenced by age, gender or duration of diabetes. This parameter is a potential early DKD biomarker.

scholarly journals Serum zonulin levels in type 2 diabetes patients with diabetic kidney disease

2021 ◽  
Author(s):  
Fevziye Burcu Sirin ◽  
Hakan Korkmaz ◽  
Ismet Eroglu ◽  
Barıs Afsar ◽  
Duygu Kumbul Doguc
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Diabetes Patients

scholarly journals Urinary A- and C-megalin predict progression of diabetic kidney disease: a retrospective cohort study

2021 ◽  
Author(s):  
Tomomichi Iida ◽  
Michihiro Hosojima ◽  
Hideyuki Kabasawa ◽  
Keiko Kabasawa ◽  
Sawako Goto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Estimating Equation ◽  
Sglt2 Inhibitors ◽  
Diabetic Kidney ◽  
Novel Method ◽  
Egfr Slope ◽  
Diabetes Patients

Abstract Background Urinary excretion of megalin, a proximal tubular endocytic receptor, may be associated with the development and progression of diabetic kidney disease (DKD). However, no studies have assessed whether the levels of the urinary ectodomain (A-megalin) and full-length (C-megalin) forms of megalin can predict DKD progression. Methods We evaluated the correlation of urinary A-megalin levels of 34 patients with type 2 diabetes as measured by novel reducing and previous methods. Then, we retrospectively analyzed 188 type 2 diabetes patients not taking sodium glucose cotransporter 2 (SGLT2) inhibitors in order to investigate whether urinary A- and C-megalin might be used as predictors of kidney outcomes. The median observation period was 3.96 years. The associations between the baseline urinary A-megalin measured by the novel method and/or C-megalin levels and the subsequent estimated glomerular filtration rate (eGFR) slope were analyzed using a generalized estimating equation. Patients were categorized into higher or lower groups based on the optimal cutoff values, obtained from a receiver operating characteristic (ROC) curve, of the two forms of urinary megalin. Results Urinary A-megalin levels measured by the two methods were strongly correlated. The eGFR slopes of the higher A-megalin and C-megalin groups were −0.904 (95% confidence interval [CI] −1.584, −0.224) and −0.749 (95% CI −1.312, −0.186) ml/min/1.73 m2 per year steeper than those of the lower groups, respectively. Moreover, the eGFR slope was −1.888 (95% CI −2.764, −1.011) ml/min/1.73 m2 per year steeper in the group with both higher A- and higher C-megalin than in the other groups. These results remained significant when adjusted for albuminuria or known tubular injury markers. Conclusions Our novel method allows urinary A-megalin measurements to be performed more easily. Baseline urinary megalin levels were associated with the subsequent eGFR slope independently of known biomarkers in type 2 diabetes patients not receiving SGLT2 inhibitors. These two forms of megalin may be distinct urinary biomarkers of the progression of DKD.

Albuminuria Is More Closely Associated with Vascular Endothelial Function than eGFR in Type 2 Diabetes with Diabetic Kidney Disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 443-P
Author(s):  
YOSHINORI KAKUTANI ◽  
MASANORI EMOTO ◽  
YUKO YAMAZAKI ◽  
KOKA MOTOYAMA ◽  
TOMOAKI MORIOKA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Endothelial Function ◽  
Diabetic Kidney Disease ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Diabetic Kidney
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