scholarly journals Serum Total Sialic Acid Level is Elevated in Hypothyroid Patients as an Atherosclerotic Risk Factor

2016 ◽  
Vol 31 (2) ◽  
pp. e22034 ◽  
Author(s):  
Mustafa Altay ◽  
Mehmet Ayhan Karakoç ◽  
Nuri Çakır ◽  
Canan Yılmaz Demirtaş ◽  
Ethem Turgay Cerit ◽  
...  
Keyword(s):  
Risk Factor ◽  
Sialic Acid ◽  
Acid Level ◽  
Total Sialic Acid ◽  
Atherosclerotic Risk Factor ◽  
Hypothyroid Patients

Met-enkephalin modulates lipid peroxidation and total sialic acid level in CBA mice in age- and sex-dependent manners

2002 ◽  
Vol 37 (12) ◽  
pp. 1413-1421 ◽  
Author(s):  
Višnja Šverko ◽  
Sandra Sobočanec ◽  
Tihomir Balog ◽  
Tatjana Marotti
Keyword(s):  
Lipid Peroxidation ◽  
Sialic Acid ◽  
Acid Level ◽  
Cba Mice ◽  
Total Sialic Acid ◽  
Age And Sex

Serum Sialic Acid, a Reputed Cardiovascular Risk Factor, is Elevated in South Asian Men Compared to European Men

1998 ◽  
Vol 35 (2) ◽  
pp. 242-244 ◽  
Author(s):  
M Crook ◽  
P Kerai ◽  
V Andrews ◽  
P Lumb ◽  
R Swaminathan
Keyword(s):  
Risk Factor ◽  
Cardiovascular Risk ◽  
Sialic Acid ◽  
Racial Differences ◽  
South Asian ◽  
Cardiovascular Risk Factor ◽  
Racial Groups ◽  
Total Sialic Acid ◽  
Asian Men ◽  
Young Subjects

Serum total sialic acid (TSA) has recently been reported as a cardiovascular risk factor, but whether there are racial differences is not known. One hundred and twenty-four healthy young subjects (62 women and 62 men) were studied. Their age was 20.7 [0.9] years and they were matched for body mass index (BMI). Sixty-eight were of South Asian origin (37 women and 31 men) and 56 (25 women and 31 men) were European. Mean (SD) serum TSA was significantly higher in the South Asian men than the age-matched European men (74.3 [12.3]mg/dL versus 68.2 [13.0]mg/dL, P = 0.0198). In addition, serum TSA was significantly higher in South Asian women compared with European men (71.6 [8.9]mg/dL versus 68.2 [13.0]mg/dL, P = 0.0352). Finally, serum TSA was significantly higher in European women compared with European men (76.0 [13.1]mg/dL versus 69.2 [130]mg/dL, P = 0008). We conclude that serum TSA may be worth measuring in different racial groups and also may be useful to assess individuals at risk of cardiovascular disease. Large prospective studies may help to explain why serum TSA is a reputed cardiovascular risk factor and shows racial differences.

Salivary Total Sialic Acid Levels Increase in Breast Cancer Patients: A Preliminary Study

2011 ◽  
Vol 7 (5) ◽  
pp. 443-447 ◽  
Author(s):  
Leyla Koc Ozturk ◽  
Ebru Emekli-Alturfan ◽  
Emel Kasikci ◽  
Gokhan Demir ◽  
Aysen Yarat
Keyword(s):  
Breast Cancer ◽  
Sialic Acid ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Total Sialic Acid ◽  
Preliminary Study

scholarly journals Usefulness of sialic acid for diagnosis of sepsis in critically ill patients: a retrospective study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Bo Yao ◽  
Wen-juan Liu ◽  
Di Liu ◽  
Jin-yan Xing ◽  
Li-juan Zhang
Keyword(s):  
Sialic Acid ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Incomplete Data ◽  
Acid Level ◽  
Operating Characteristic ◽  
Area Under The Curve ◽  
Diagnostic Efficacy ◽  
Receiver Operating Characteristic Curves ◽  
Sensitivity Specificity

Abstract Background Early diagnosis of sepsis is very important. It is necessary to find effective and adequate biomarkers in order to diagnose sepsis. In this study, we compared the value of sialic acid and procalcitonin for diagnosing sepsis. Methods Newly admitted intensive care unit patients were enrolled from January 2019 to June 2019. We retrospectively collected patient data, including presence of sepsis or not, procalcitonin level and sialic acid level. Receiver operating characteristic curves for the ability of sialic acid, procalcitonin and combination of sialic acid and procalcitonin to diagnose sepsis were carried out. Results A total of 644 patients were admitted to our department from January 2019 to June 2019. The incomplete data were found in 147 patients. Finally, 497 patients data were analyzed. The sensitivity, specificity and area under the curve for the diagnosis of sepsis with sialic acid, procalcitonin and combination of sialic acid and procalcitonin were 64.2, 78.3%, 0.763; 67.9, 84.0%, 0.816 and 75.2, 84.6%, 0.854. Moreover, sialic acid had good values for diagnosing septic patients with viral infection, with 87.5% sensitivity, 82.2% specificity, and 0.882 the area under the curve. Conclusions Compared to procalcitonin, sialic acid had a lower diagnostic efficacy for diagnosing sepsis in critically ill patients. However, the combination of sialic acid and procalcitonin had a higher diagnostic efficacy for sepsis. Moreover, sialic acid had good value for diagnosing virus-induced sepsis.

Abstract 14920: Uric Acid is Neither the Risk Factor nor Prognostic Factor for 3-year Clinical Events in Vasospastic Angina Patients Regardless of Gender

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Sang-Ho Park ◽  
Seung Woon Rha ◽  
Ung Jun ◽  
Byoung Geol Choi ◽  
Se Yeon Choi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Coronary Artery ◽  
Prognostic Factor ◽  
Uric Acid Level ◽  
Acid Level ◽  
Female Gender ◽  
Male Gender ◽  
Vasospastic Angina ◽  
Clinical Events

Background: It has been reported that a major cause of vasospastic angina is endothelial dysfunction of the coronary artery. However, it is controversial whether the uric acid level is associated with vasospastic angina, and can be a prognostic factor for vasospastic angina. Methods: A total 3828 patients (pts) underwent coronary angiography with acetylcholine (Ach) provocation test from Mar 2004 to Sep 2012 were enrolled. The definition of positive coronary artery spasm (CAS) was defined as transient luminal narrowing more than 70%. The uric acid level was categorized into 4 quartile groups; less than 3.8, 3.9~4.7, 4.8~5.7, and more than 5.8 mg/dL. Major adverse cardiovascular events (MACEs) defined as the composite of recurrent chest pain, cardiac death, myocardial infarction, and cerebrovascular accident were valuated up to 3 years. Results: The follow-up rate was the 61.1% (2340/3828). There was no difference in uric acid level between negative and positive CAS groups in female gender but in male gender, uric acid level was higher in negative CAS group (Table 1). However, when adjusted by age, the difference was disappeared (OR, 0.965; 95% CI, 0.898-1.037; P-value, 0.335). The incidence of MACE was 11.1% in male gender and 8.6% in female gender. In male gender, the serum uric acid level between the groups with and without MACE was similar but in female gender, the uric acid level was higher in the group with MACE. However, when adjusted by age, uric acid was not associated with MACE (Table 2). Conclusions: In our study, uric acid was neither the risk factor nor prognostic factor for 3-year clinical events in CAS patients regardless of gender.

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