scholarly journals Biological Variation and Reference Change Value Data for Serum Neuron-Specific Enolase in a Turkish Population

2016 ◽  
Vol 30 (6) ◽  
pp. 1081-1085 ◽  
Author(s):  
Selcuk Matyar ◽  
Ozlem Goruroglu Ozturk ◽  
Esin Ziyanoglu Karacor ◽  
Sedefgul Yuzbasioglu Ariyurek ◽  
Gulhan Sahin ◽  
...  
Keyword(s):  
Neuron Specific Enolase ◽  
Turkish Population ◽  
Biological Variation ◽  
Reference Change Value ◽  
Serum Neuron Specific Enolase

scholarly journals Biological variation of serum neuron-specific enolase and carbohydrate antigen 724 tumor markers

2017 ◽  
Vol 32 (4) ◽  
pp. e22327 ◽  
Author(s):  
Shuo Wang ◽  
Min Zhao ◽  
Runqing Mu ◽  
Xin Zhang ◽  
Ke Yun ◽  
...  
Keyword(s):  
Tumor Markers ◽  
Neuron Specific Enolase ◽  
Carbohydrate Antigen ◽  
Biological Variation ◽  
Serum Neuron Specific Enolase

scholarly journals Biological variation and reference change value data for serum copper, zinc and selenium in Turkish adult population

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ceylan Bal ◽  
Serpil Erdogan ◽  
Gamze Gök ◽  
Cemil Nural ◽  
Betül Özbek ◽  
...  
Keyword(s):  
Adult Population ◽  
Reference Intervals ◽  
Serum Copper ◽  
Biological Variation ◽  
Serum Samples ◽  
Reference Change Value ◽  
Index Of Individuality ◽  
Copper Zinc ◽  
Clinically Significant ◽  
Analytical Variation

Abstract Objectives Calculation of biological variation (BV) components is very important in evaluating whether a test result is clinically significant. The aim of this study is to analyze BV components for copper, zinc and selenium in a cohort of healthy Turkish participants. Methods A total of 10 serum samples were collected from each of the 15 healthy individuals (nine female, six male), once a week, during 10 weeks. Copper, zinc and selenium levels were analyzed by atomic absorption spectrometer. BV parameters were calculated with the approach suggested by Fraser. Results Analytical variation (CVA), within-subject BV (CVI), between-subject BV (CVG) values were 8.4, 7.1 and 4.3 for copper; 4.2, 9.1 and 13.7 for zinc; 7.6, 2.5 and 6.9 for selenium, respectively. Reference change values (RCV) were 30.46, 27.56 and 22.16% for copper, zinc and selenium, respectively. The index of individuality (II) values were 1.65, 0.66 and 0.36 for copper, zinc and selenium, respectively. Conclusions According to the results of this study, traditional reference intervals can be used for copper but we do not recommend using it for zinc and selenium. We think that it would be more accurate to use RCV value for zinc and selenium in terms of following significant changes in recurrent results of a patient.

SERUM NEURON-SPECIFIC ENOLASE: A MARKER FOR DISEASE EXTENT AND RESPONSE TO THERAPY OF SMALL-CELL LUNG CANCER

The Lancet ◽  
1982 ◽  
Vol 319 (8272) ◽  
pp. 583-585 ◽  
Author(s):  
DesmondN Carney ◽  
DanielC Ihde ◽  
MartinH Cohen ◽  
PaulJ Marangos ◽  
PaulA Bunn ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Neuron Specific Enolase ◽  
Small Cell ◽  
Response To Therapy ◽  
Small Cell Lung ◽  
Disease Extent ◽  
Serum Neuron Specific Enolase

Serum neuron-specific enolase levels do not increase after electroconvulsive therapy

1997 ◽  
Vol 150 (2) ◽  
pp. 173-176 ◽  
Author(s):  
Jörg Berrouschot ◽  
Kathrin Rolle ◽  
Hans-Jürgen Kühn ◽  
Dietmar Schneider
Keyword(s):  
Electroconvulsive Therapy ◽  
Neuron Specific Enolase ◽  
Serum Neuron Specific Enolase

Evaluation of serum neuron specific enolase levels among patients with primary and secondary burning mouth syndrome

Cephalalgia ◽  
2021 ◽  
pp. 033310242110466
Author(s):  
Jaimala Kishore ◽  
Fouzia Shaikh ◽  
Adnan Mustafa Zubairi ◽  
Sana Mirza ◽  
Montaser N Alqutub ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Spinal Cord Injuries ◽  
Clinical Symptoms ◽  
Neuron Specific Enolase ◽  
Burning Mouth Syndrome ◽  
Enzyme Linked Immunosorbent Assay ◽  
Painful Condition ◽  
Burning Mouth ◽  
A Minor ◽  
Serum Neuron Specific Enolase

Introduction Burning mouth syndrome is a painful condition of the oral cavity with ambiguous pathogenesis and diagnosis. Neuron-specific enolase is increased in several conditions including peripheral neuropathy of diabetes, ophthalmopathies, spinal cord injuries and tumors. Evidence on association of burning mouth syndrome and neuron-specific enolase is limited. Aim This study aims to evaluate neuron-specific enolase levels in primary and secondary burning mouth syndrome patients and compare the levels of neuron-specific enolase with associated conditions in secondary burning mouth syndrome. Methods One hundred and twenty-eight patients of more than 18 years of age with no gender predilection and having clinical symptoms of burning mouth syndrome and 135 healthy subjects were included. All the patients fulfilled Scala’s criteria for the diagnosis of burning mouth syndrome, including “primary” (idiopathic) and “secondary” (resulting from identified precipitating factors) burning mouth syndrome patients. Blood samples were obtained from burning mouth syndrome patients. Serum neuron-specific enolase was evaluated using enzyme-linked immunosorbent assay. To compare means and standard deviations, among primary and secondary burning mouth syndrome, data was analysed with analysis of variance and multiple comparisons test. Results The mean age of the study participants for burning mouth syndrome and healthy subjects was 53.30 and 51.6 years, respectively. Amongst the secondary burning mouth syndrome group, 32 (25%) of the patients had menopause, 15 (11.7%) had diabetes, eight (6.2%) of the patients had nutritional deficiency, seven (5.4%) had combined diabetes, menopause, and depression, six (4.6%) had combined diabetes and depression, four (3.1%) were diagnosed with Sjögren’s syndrome. A minor percentage of 2.3% (three) had gastroesophageal reflux disease, while the remaining three (2.3%) patients in the secondary burning mouth syndrome group were on anti-depressants. There was a statistically significant increase in the levels of neuron-specific enolase in primary burning mouth syndrome as compared to the secondary burning mouth syndrome and healthy groups. Among the subgroups of secondary burning mouth syndrome, diabetic individuals showed a significant increase in neuron-specific enolase level when compared with other conditions in the secondary burning mouth syndrome patients. Discussion and conclusion: The raised serum neuron-specific enolase levels in patients suffering from primary burning mouth syndrome highlight a possible neuropathic mechanism. It was also increased in the sub-group of secondary burning mouth syndrome patients having diabetes. Although it cannot be ascertained whether the deranged values in the diabetic group were due to burning mouth syndrome or due to diabetes, the raised quantity of neuron-specific enolase in the primary burning mouth syndrome group is a reliable diagnostic indicator. Future studies on the assessment of neuron-specific enolase levels as a diagnostic tool for onset and management of primary and secondary burning mouth syndrome are recommended.

Annual biological variation and personalized reference intervals of clinical chemistry and hematology analytes

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shuo Wang ◽  
Min Zhao ◽  
Zihan Su ◽  
Runqing Mu
Keyword(s):  
Clinical Chemistry ◽  
Population Based ◽  
Reference Intervals ◽  
Biological Variation ◽  
Annual Data ◽  
Healthy Individuals ◽  
Reference Change Value ◽  
Index Of Individuality ◽  
Personalized Diagnosis

Abstract Objectives A large number of people undergo annual health checkup but accurate laboratory criterion for evaluating their health status is limited. The present study determined annual biological variation (BV) and derived parameters of common laboratory analytes in order to accurately evaluate the test results of the annual healthcare population. Methods A total of 43 healthy individuals who had regular healthcare once a year for six consecutive years, were enrolled using physical, electrocardiogram, ultrasonography and laboratory. The annual BV data and derived parameters, such as reference change value (RCV) and index of individuality (II) were calculated and compared with weekly data. We used annual BV and homeostatic set point to calculate personalized reference intervals (RIper) which were compared with population-based reference intervals (RIpop). Results We have established the annual within-subject BV (CVI), RCV, II, RIper of 24 commonly used clinical chemistry and hematology analytes for healthy individuals. Among the 18 comparable measurands, CVI estimates of annual data for 11 measurands were significantly higher than the weekly data. Approximately 50% measurands of II were <0.6, the utility of their RIpop were limited. The distribution range of RIper for most measurands only copied small part of RIpop with reference range index for 8 measurands <0.5. Conclusions Compared with weekly BV, for annual healthcare individuals, annual BV and related parameters can provide more accurate evaluation of laboratory results. RIper based on long-term BV data is very valuable for “personalized” diagnosis on annual health assessments.

scholarly journals Serum neuron-specific enolase, a marker of neuronal injury, increases after catheter ablation of atrial fibrillation

2018 ◽  
Vol 46 (11) ◽  
pp. 4518-4526 ◽  
Author(s):  
Aynur Acibuca ◽  
Veysel Kutay Vurgun ◽  
Demet Menekse Gerede ◽  
Ali Timucin Altin ◽  
Inci Sule Gul ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Neuron Specific Enolase ◽  
Clinical Importance ◽  
Neuronal Injury ◽  
Neurological Deficits ◽  
Reference Limit ◽  
Before And After ◽  
Upper Reference Limit ◽  
Serum Neuron Specific Enolase

Objective Catheter ablation of atrial fibrillation (AF) can lead to thromboembolic complications, especially stroke. We measured the periprocedural serum neuron-specific enolase (NSE) level, which is a biomarker of neuronal injury, after ablation of AF. Methods Forty-three patients with paroxysmal AF were prospectively enrolled before radiofrequency ablation. A neurological examination was performed before and after the procedure. The serum NSE level was determined before and at the end of the procedure and at 2, 24, and 48 h after the procedure. Results No patients developed new neurological deficits. However, the median (interquartile range) NSE level increased after ablation from 6.7 (3.87) ng/mL at baseline to 11.48 (5.3) ng/mL at 24 h postoperatively. The NSE level exceed the upper reference limit of normal (17 ng/mL) in 14 patients (33%), and these patients were found to have a larger left atrium. Conclusions Serum NSE increased in most of the patients undergoing ablation for AF, and it exceeded the normal limit in one-third of the patients. Although NSE is a biomarker of neuronal injury, the clinical importance of this increase after AF ablation and its relationship with the left atrial diameter should be evaluated in a longitudinal study.

SERUM NEURON-SPECIFIC ENOLASE MAY BE RAISED IN CHILDREN WITH WILMS' TUMOUR

The Lancet ◽  
1987 ◽  
Vol 329 (8524) ◽  
pp. 110 ◽  
Author(s):  
J. Pritchard ◽  
E.H. Cooper ◽  
S. Hamilton ◽  
C.C. Bailey ◽  
J. Ninane
Keyword(s):  
Neuron Specific Enolase ◽  
Wilms Tumour ◽  
Serum Neuron Specific Enolase

Serum Levels of Neuron-Specific Enolase in Children With Diabetic Ketoacidosis

2017 ◽  
Vol 32 (5) ◽  
pp. 475-481 ◽  
Author(s):  
Sherifa Hamed ◽  
Kotb Abbass Metwalley ◽  
Hekma Saad Farghaly ◽  
Tahra Sherief
Keyword(s):  
Diabetic Ketoacidosis ◽  
Neuronal Damage ◽  
Neuron Specific Enolase ◽  
Serum Levels ◽  
Time Points ◽  
Factors Associated ◽  
Neurologic Disorders ◽  
Younger Age ◽  
Serum Neuron Specific Enolase ◽  
Sensitive Marker

Neuron-specific enolase is a sensitive marker of neuronal damage in various neurologic disorders. This study aimed to measure serum neuron-specific enolase levels at different time points and severities of diabetic ketoacidosis. This study included 90 children (age 9.2 ± 3.4 years) with diabetic ketoacidosis. Neuron-specific enolase was measured at 3 time points (baseline and after 12 and 24 hours of starting treatment). Among patients, 74.4% had diagnosis of new diabetes, 60% had Glasgow Coma Scale score <15, and 75.6% had moderate/severe diabetic ketoacidosis. Compared with controls (n = 30), children with diabetic ketoacidosis had higher neuron-specific enolase levels at the 3 time points ( P = .0001). In multiple regression analysis, the factors associated with higher neuron-specific enolase levels were younger age, higher glucose, lower pH, and bicarbonate values. This study indicates that serum neuron-specific enolase is elevated in diabetic ketoacidosis and correlated with the severity of hyperglycemia, ketosis, and acidosis. This study indicates that diabetic ketoacidosis may cause neuronal injury from which the patients recovered partially but not completely.

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