scholarly journals Influence of Phosphatidylethanolamine Concentration and Composition on the Detection of Antiphosphatidylethanolamine Antibodies by ELISA

2016 ◽  
Vol 30 (5) ◽  
pp. 689-696 ◽  
Author(s):  
Ke Ke ◽  
Zachariah I. Strango ◽  
Paul E. Harper ◽  
Ming Zhao
Keyword(s):  
Antiphosphatidylethanolamine Antibodies

Childhood-Onset Systemic Lupus Erythematosus: Antiphospholipid Antibodies in 37 Patients and Their First-Degree Relatives

PEDIATRICS ◽  
1993 ◽  
Vol 92 (6) ◽  
pp. 849-853
Author(s):  
Charles Molta ◽  
Olivier Meyer ◽  
Christine Dosquet ◽  
Marcela Montes de Oca ◽  
Marie-Claude Babron ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Clinical Manifestations ◽  
Fetal Loss ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
First Degree Relatives ◽  
Antiphosphatidylethanolamine Antibodies ◽  
Onset Systemic Lupus Erythematosus

Objective. Antiphospholipid antibodies (aPL) are noted with increased frequency in patients with systemic lupus erythematosus (SLE). The main manifestations found to be associated with aPL are arterial and venous thrombotic events, thrombocytopenia, and recurrent pregnancy loss This study is an attempt to define the incidence of aPL in patients with childhood-onset SLE and in their relatives and to correlate their presence with clinical manifestations, and especially, to evaluate the risk of thrombosis in aPL-positive subjects. Methodology. We studied 37 unrelated patients and 107 of their first-degree relatives. VDRL, IgG and IgM anticardiolipin, and IgG antiphosphatidylethanolamine antibodies were studied in all probands during periods of clinical remission and in first-degree relatives at the time of interview. Lupus anticoagulant had only been studied in probands during an SLE flare-up. Results. Thirty-eight percent of probands and 19% of relatives were positive for at least one aPL, with little over-lap between the different aPL studied. -No aPL-negative proband developed thrombosis. Two of the aPL-positive probands had thrombotic events before testing, and a third one showed thrombosis after testing. Only two probands had high levels of IgG aCL and showed thrombosis. The occurrence of aPL positivity in relatives was not always related to its presence in probands. None of the aPL-positive relatives had hadthrombosis, but recurrent fetal loss was noted in one aPL-positive mother with SLE. Although there was a high frequency of SLE, SLE-like disease, auto-immune disorders or positive serological findings for lupus in first-degree relatives, many of these relativew did not test positive for aPL. Conclusion. The high levels of IgG aCL may be considered a risk factor for thrombosis. Findings in relatives suggest a multifactorial origin for autoimmune disease and antibody production.

Antiphosphatidylethanolamine Antibodies in Systemic Lupus Erythematosus

Lupus ◽  
1993 ◽  
Vol 2 (3) ◽  
pp. 157-160 ◽  
Author(s):  
M. Karmochkine ◽  
M. Berard ◽  
J.C. Piette ◽  
P. Cacoub ◽  
M.F. Aillaud ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Antiphosphatidylethanolamine Antibodies

scholarly journals Kininogen domain 3 contains regions recognized by antiphosphatidylethanolamine antibodies

2003 ◽  
Vol 1 (1) ◽  
pp. 132-138 ◽  
Author(s):  
J. Katsunuma ◽  
T. Sugi ◽  
A. Inomo ◽  
H. Matsubayashi ◽  
S-I Izumi ◽  
...  
Keyword(s):  
Domain 3 ◽  
Antiphosphatidylethanolamine Antibodies

Prevalence and heterogeneity of antiphosphatidylethanolamine antibodies in patients with recurrent early pregnancy losses

1999 ◽  
Vol 71 (6) ◽  
pp. 1060-1065 ◽  
Author(s):  
Toshitaka Sugi ◽  
Junko Katsunuma ◽  
Shun-ichiro Izumi ◽  
John A McIntyre ◽  
Tsunehisa Makino
Keyword(s):  
Early Pregnancy ◽  
Antiphosphatidylethanolamine Antibodies

Antibodies to Phosphatidylethanolamine as the only Antiphospholipid Antibodies Found in Patients with Unexplained Thromboses

2001 ◽  
Vol 85 (05) ◽  
pp. 800-805 ◽  
Author(s):  
Marie-Christine Alessi ◽  
Jean Robert Harle ◽  
Christophe Sapin ◽  
Marie-Françoise Aillaud ◽  
Stéphanie Gentile ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Infectious Diseases ◽  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Blood Donors ◽  
Systemic Lupus ◽  
A Site ◽  
Antiphosphatidylethanolamine Antibodies ◽  
Biological Variant

SummaryThe objective of this study was to assess the interest of antiphosphatidylethanolamine antibodies (aPE) in unexplained thrombosis (UT) defined as thrombotic episode without any of the main autoimmune and hereditary thrombophilic defects. Results from 98 UT were compared to those of (I) 142 patients with thrombophilia: 67 antiphospholipid syndrome (APS) and 75 hereditary hemostatic defects (HHD); (II) 110 patients without thrombosis: 60 with systemic lupus erythematosus (SLE) and 50 with infectious diseases (ID). As compared to controls (100 blood donors), aPE prevalence was significantly higher in both autoimmune contexts (APS: 43%; SLE: 40%, p <0.0001) and among non-autoimmune pathologies, only in UT (18%, p = 0.001) conversely to HHD (8%) or ID (10%). aPE prevalence in UT was not statistically different from that found in Primary APS (32%, p = 0.076) but lower than in Secondary APS (65%, p <0.005). In UT, aPE were mainly of IgM isotype like in Primary APS and they were found alone whereas in SLE they were always associated with classical anti-phospholipid antibodies. No significant association was found between any isotype of aPE and a site of thrombosis in UT as well as in APS. In conclusion, this study demonstrates an increase of the prevalence of aPE in patients with unexplained thrombosis. Thus, aPE investigation appears to be of interest in UT and their persistent presence could define a biological variant of APS.

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