scholarly journals Noninvasive Diagnosis of Liver Fibrosis and Cirrhosis in Chronic Hepatitis C Patients

2013 ◽  
Vol 27 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Abdelfattah M. Attallah ◽  
Mohamed El-Far ◽  
Mohamed M. Omran ◽  
Khaled Farid ◽  
Mohamed S. Albannan ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Noninvasive Diagnosis ◽  
Chronic Hepatitis C Patients

Insulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patients

2005 ◽  
Vol 42 (1) ◽  
pp. 41-46 ◽  
Author(s):  
A MUZZI ◽  
G LEANDRO ◽  
L RUBBIABRANDT ◽  
R JAMES ◽  
O KEISER ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis C Patients

scholarly journals Association of TM6SF2 rs58542926 with Hepatic and Extrahepatic Alterations in Chronic Hepatitis C Patients

2021 ◽  
Author(s):  
Mohi I. Mohammed Abdul ◽  
Adriana Vitiello ◽  
Hanieh Ghassabian ◽  
Heba M. Eltahir ◽  
Elham Ahmed Hassan ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Biochemical Analysis ◽  
Complete Blood Count ◽  
Minor Allele ◽  
Chronic Hepatitis C Patients ◽  
Severe Fibrosis

Abstract Human genetic variants play major roles in predicting and prognosis of several diseases. The effect of rs58542926 variant in transmembrane 6 superfamily member 2 (TM6SF2) gene on liver fibrosis among patients with chronic hepatitis C (CHC) is still debatable. The aim of this study is to investigate the possible effects of this variant in CHC patients. The study comprised 351 subjects: 250 CHC patients with different fibrosis stages (F0-F4) and 101 healthy volunteers. TM6SF2 (rs58542926) genotype was determined for all subjects. Blood samples were collected for complete blood count and biochemical analysis and cohort subjects were genotyped for the variant TM6SF2 rs58542926. Fibrosis staging was performed using Fibrotest and Fibroscan standard tests. The presence of the minor allele was significantly associated with severe liver fibrosis, as well as thrombocytopenia as an extrahepatic alteration. In addition, there was a significant association between the minor allele and lower thrombopoietin levels. The association of TM6SF2 genotype with thrombocytopenia was explored by measuring plasma thrombopoietin (TPO) levels for CHC patients. The results showed an association with extrahepatic alteration (thrombocytopenia) through its effect on plasma TPO level, and consequently on platelets production, which raises questions about the role of this variant in HCV treatment outcome. In conclusion, the occurrence of the minor allele of the variant rs58542926 can be linked to severe fibrosis stages as well as thrombocytopenia, enabling this variant to be used as a diagnostic pharmacogenetic marker for predicting the risk of fibrosis onset in CHC patients.

Novel scores combining AFP with non-invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

2018 ◽  
Vol 90 (6) ◽  
pp. 1080-1086 ◽  
Author(s):  
Mohamed Gamil ◽  
Mohamed Alboraie ◽  
Mohammad El-Sayed ◽  
Aisha Elsharkawy ◽  
Noha Asem ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Non Invasive ◽  
Chronic Hepatitis C Patients

Association Between Liver Fibrosis and Insulin Sensitivity in Chronic Hepatitis C Patients

2006 ◽  
Vol 101 (12) ◽  
pp. 2752-2759 ◽  
Author(s):  
Naota Taura ◽  
Tatsuki Ichikawa ◽  
Keisuke Hamasaki ◽  
Kazuhiko Nakao ◽  
Daisuke Nishimura ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Insulin Sensitivity ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis C Patients

scholarly journals Liver Fibrosis in Patients with Chronic Hepatitis C: Noninvasive Diagnosis by Means of Real-time Tissue Elastography—Establishment of the Method for Measurement

Radiology ◽  
2011 ◽  
Vol 258 (2) ◽  
pp. 610-617 ◽  
Author(s):  
Yohei Koizumi ◽  
Masashi Hirooka ◽  
Yoshiyasu Kisaka ◽  
Ichiro Konishi ◽  
Masanori Abe ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Real Time ◽  
Chronic Hepatitis C ◽  
Noninvasive Diagnosis ◽  
Tissue Elastography

[627] EFFECTS OF PPAR-GAMMA LIGAND ROSIGLITAZONE ON LIVER FIBROSIS IN CHRONIC HEPATITIS C PATIENTS

2007 ◽  
Vol 46 ◽  
pp. S237 ◽  
Author(s):  
N. Passariello ◽  
A. Peluso ◽  
G. Passariello ◽  
G. Moniello ◽  
A. Maio ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Ppar Gamma ◽  
Chronic Hepatitis C Patients
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