scholarly journals Serum Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 as Predictive Biomarkers for Delayed Graft Function After Kidney Transplantation

2012 ◽  
Vol 26 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Eun Young Lee ◽  
Myoung Soo Kim ◽  
Yongjung Park ◽  
Hyon-Suk Kim
Keyword(s):  
Kidney Transplantation ◽  
Graft Function ◽  
Predictive Biomarkers ◽  
Delayed Graft Function ◽  
Interleukin 18 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

scholarly journals The Predictive value of serum NGAL for the diagnosis of Delayed Graft Function in kidney transplantation

2020 ◽  
Author(s):  
Gholamreza Pourmand ◽  
Behrouz Emamjomeh ◽  
Shahram Gooran ◽  
Farshad Namdari ◽  
Abdolrasool Mehrsay ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Urine Output ◽  
Graft Function ◽  
Roc Curves ◽  
Delayed Graft Function ◽  
Postoperative Phase ◽  
Post Transplantation ◽  
Significant Independent Predictor ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Abstract Background and aims the role of serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting delayed graft function (DGF) after kidney transplantation is poorly defined. The objective of this study was to evaluate the serum NGAL expression in the early postoperative phase after kidney transplantation and compare it with serum creatinine (Cr). Methods We studied 32 patients who received kidney transplantation from deceased (n=24) and live (n=5) donors during October 2017 to December 2018 at the Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Serum NGAL, Serum Cr and urine output were measured at 1 to 7 day after transplantation. The need for dialysis in one week after transplantation was evaluated. Results Among 29 recipients with serum biomarkers measurements, 8 (27.5%) developed DGF (need to hemodialysis within 1 week of transplantation). Resulted in areas under ROC curves (AUCs) for serum NGAL at early hours following transplantation was (0.839, 95% CI: 0.69-0.98, P =0.005) that could accurately predict DGF compared to urine output (0.747, 95% CI: 0.55-0.93, P =0.045) and serum Cr (0.607, 95% CI: 0.34-0.86, P =0.398) at 24 hours after transplantation. Multivariate analysis revealed that only serum NGAL was significant independent predictor of DGF (OR: 0.996, 95% CI: 0.993-1.000, P =0.039). Conclusion Serum NGAL at early hours of post-transplantation was valuable biomarker for early accurate predictor of DGF in kidney transplantation compare with tradition biomarkers such as serum Cr and urine output.

scholarly journals Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Isabel Fonseca ◽  
José Carlos Oliveira ◽  
Manuela Almeida ◽  
Madalena Cruz ◽  
Anabela Malho ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Serum Creatinine ◽  
Graft Function ◽  
Roc Curves ◽  
First Year ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Early Marker ◽  
One Year ◽  
A Prospective Study ◽  
Neutrophil Gelatinase

Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been suggested as potential early marker of delayed graft function (DGF) following kidney transplantation (KTx). We conducted a prospective study in 40 consecutive KTx recipients to evaluate serial changes of uNGAL within the first week after KTx and assess its performance in predicting DGF (dialysis requirement during initial posttransplant week) and graft function throughout first year. Urine samples were collected on post-KTx days 0, 1, 2, 4, and 7. Linear mixed and multivariable regression models, receiver-operating characteristic (ROC), and areas under ROC curves were used. At all-time points, mean uNGAL levels were significantly higher in patients developing DGF (n=18). Shortly after KTx (3–6 h), uNGAL values were higher in DGF recipients (on average +242 ng/mL, considering mean dialysis time of 4.1 years) and rose further in following days, contrasting with prompt function recipients. Day-1 uNGAL levels accurately predicted DGF (AUC-ROC = 0.93), with a performance higher than serum creatinine (AUC-ROC = 0.76), and similar to cystatin C (AUC-ROC = 0.95). Multivariable analyses revealed that uNGAL levels at days 4 and 7 were strongly associated with one-year serum creatinine. Urinary NGAL is an early marker of graft injury and is independently associated with dialysis requirement within one week after KTx and one-year graft function.

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