scholarly journals Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto's thyroiditis in Chinese patients in Taiwan

2006 ◽  
Vol 20 (3) ◽  
pp. 109-112 ◽  
Author(s):  
Wei-Yong Lin ◽  
Lei Wan ◽  
Chang-Hai Tsai ◽  
Rong-Hsing Chen ◽  
Cheng-Chun Lee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Hashimoto’S Thyroiditis ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Chinese Patients ◽  
Hashimoto's Thyroiditis ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms

Vitamin D receptor gene polymorphisms/haplotypes and serum 25(OH)D3 levels in Hashimoto’s thyroiditis

Endocrine ◽  
2016 ◽  
Vol 55 (2) ◽  
pp. 599-606 ◽  
Author(s):  
Salvatore Giovinazzo ◽  
Teresa M. Vicchio ◽  
Rosaria Certo ◽  
Angela Alibrandi ◽  
Orazio Palmieri ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Hashimoto’S Thyroiditis ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Hashimoto's Thyroiditis ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms

scholarly journals Association of Vitamin D deficiency and Vitamin D Receptor Gene Polymorphisms with Type 2 diabetes mellitus Saudi patients

1970 ◽  
Vol 19 (4) ◽  
pp. 2812-2818
Author(s):  
Ayman S Al-Hazmi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms ◽  
25 Oh Vitamin D

Background: Type 2 diabetes mellitus (T2DM) is a global problem. Association of multiple genes in T2DM becomes a hot point recently. This study was aimed to evaluate association of vitamin D receptor gene polymorphisms with susceptibility to T2DM. Subjects and methods: One hundred T2DM Saudi male patients were included in this study and one hundred healthy Saudi men were used as control. For each individual, fasting blood glucose, cholesterol, HDL-C, LDL-C, HbA1c, insulin and 25-(OH) vitamin D were measured. In addition, Apal, BsmI and TaqI genotypes were performed for each subject. Data was analyzed by SPSS version 16, using Spearman's rho and ANOVA tests. Results: There was significant inverse correlation between 25-(OH) vitamin D level and T2DM (p<0.01). HbA1c was inversely correlated with 25-(OH) vitamin D level (P<0.05). Genotype study showed that tt of TaqI genotype was higher in T2DM group compared with control group (p<0.05). Moreover, tt genotype has higher HbA1c than both TT and Tt genotypes (p<0.05). Conclusion: An association was confirmed between TaqI genotypes and T2DM but there is no correlation between BsmI, ApaI and T2DM. In addition, HbA1c is positively correlated with tt genotype of TaqI.Keywords: Vitamin D receptor, diabetes type 2, polymorphism.

Sign in / Sign up

Export Citation Format

Share Document