Eco‐friendly, ultrasound‐assisted, and facile synthesis of one‐pot multicomponent reaction of acridine‐1,8(2H,5H)‐diones in an aqueous solvent

2019 ◽  
Vol 66 (8) ◽  
pp. 822-828 ◽  
Author(s):  
Pravin N. Chavan ◽  
Dattatraya N. Pansare ◽  
Rohini N. Shelke
Keyword(s):  
Multicomponent Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Aqueous Solvent ◽  
Ultrasound Assisted

scholarly journals One-pot sequential multicomponent reaction between in situ generated aldimines and succinaldehyde: facile synthesis of substituted pyrrole-3-carbaldehydes and applications towards medicinally important fused heterocycles

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15448-15458 ◽  
Author(s):  
Anoop Singh ◽  
Nisar A. Mir ◽  
Sachin Choudhary ◽  
Deepika Singh ◽  
Preetika Sharma ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Component Method ◽  
Fused Heterocycles

An efficient sequential multi-component method for the synthesis of N-arylpyrrole-3-carbaldehydes has been developed.

scholarly journals Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

RSC Advances ◽  
2019 ◽  
Vol 9 (68) ◽  
pp. 39735-39742 ◽  
Author(s):  
Trimurti L. Lambat ◽  
Ahmed A. Abdala ◽  
Sami Mahmood ◽  
Pankaj V. Ledade ◽  
Ratiram G. Chaudhary ◽  
...  
Keyword(s):  
Ball Milling ◽  
Multicomponent Reaction ◽  
Sulfamic Acid ◽  
Facile Synthesis ◽  
One Pot ◽  
One Pot Synthesis

We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions.

scholarly journals Facile Synthesis of 5,6,7,8-tetrahydropyrimido[4,5-d] pyrimidine-2,4 (1H,3H) -dione Analogs via One Pot Multicomponent Reaction

2020 ◽  
Vol 1 (1) ◽  
pp. 1-8
Author(s):  
Shumaila Shafi ◽  
Ammara Chand ◽  
Mehwish Nawaz ◽  
Rashida Parveen ◽  
Saba Munawar ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Multicomponent Reaction ◽  
Heterocyclic Compounds ◽  
Biological Significance ◽  
Biological Properties ◽  
Facile Synthesis ◽  
One Pot ◽  
Conventional Methods ◽  
Work Up

Indeed, MCR technology is widely acknowledged now for its impact on drug discovery projects and is strongly supported by industry as well as academia. Uracil is an important one of the five nucleobases and significantly important because of their biological properties; of which 6-amino uracil is most important and can act as nucleophile and electrophile. 6-Aminouracils being rich are used as starting materials for the synthesis of heterocyclic compounds of biological significance such as pyrido-, pyrazolo, pyrimido and pyrimidines derivatives. 5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione have been synthesized by various conventional methods. However, these methods have drawbacks such as unsatisfactory yields and tedious work-up etc.  In the present work, we would like to report a new route for the synthesis of 5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4 (1H,3H)-dione in MCRs.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

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