Synthesis and Antifungal Activity Evaluation of Novel Substituted Pyrimidine-5-Carboxamides Bearing the Pyridine Moiety

2018 ◽  
Vol 65 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Shi-Chun Wang ◽  
Fu-Xian Wan ◽  
Si Liu ◽  
Shuai Zhang ◽  
Lin Jiang
Keyword(s):  
Antifungal Activity ◽  
Activity Evaluation ◽  
Pyridine Moiety

Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

2016 ◽  
Vol 13 (6) ◽  
pp. 521-525 ◽  
Author(s):  
Zhi-Wen Zhai ◽  
Yan-Xia Shi ◽  
Ming-Yan Yang ◽  
Wen Zhao ◽  
Zhao-Hui Sun ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Pyridine Moiety

Synthesis, Characterization, and Antifungal Activity Evaluation of Some Novel Arylazothiazoles

2017 ◽  
Vol 55 (1) ◽  
pp. 258-264 ◽  
Author(s):  
Salama A. Ouf ◽  
Sobhi M. Gomha ◽  
Mohamed M. Ewies ◽  
Ihab A. A. Sharawy
Keyword(s):  
Antifungal Activity ◽  
Activity Evaluation

scholarly journals Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors

2019 ◽  
Vol 70 (10) ◽  
pp. 3522-3526
Author(s):  
Smaranda Oniga ◽  
Catalin Araniciu ◽  
Gabriel Marc ◽  
Livia Uncu ◽  
Mariana Palage ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Molecular Docking ◽  
Antifungal Activity ◽  
Active Site ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Activity Evaluation ◽  
Lanosterol Demethylase ◽  
Target Enzyme

Considering the well-established antifungal activity of azole compounds, a new series of thiazolyl-methylen-1,3,4-oxadiazolines derivatives were designed and synthesized as lanosterol-demethylase inhibitors. The final compounds were screened for antifungal activity against the Candida albicans ATCC 90028 strain. Molecular docking studies were performed to investigate the interaction modes between the compounds and the active site of lanosterol 14a-demethylase, which is a target enzyme for anticandidal azoles. Theoretical ADME predictions were also calculated for the final compounds 5a-h.

Synthesis of 1,3,4-Oxadiazole derivatives with its Antifungal Activity Evaluation

2021 ◽  
pp. 336-338
Author(s):  
Anuja Patil ◽  
Mohite Shriniwas
Keyword(s):  
Salicylic Acid ◽  
Antifungal Activity ◽  
Toxic Effects ◽  
Pharmacological Properties ◽  
Microbial Infection ◽  
Activity Profile ◽  
Activity Evaluation ◽  
Development Of Resistance ◽  
Wide Range ◽  
Oxadiazole Derivatives

Azole exhibits wide range of pharmacological properties. there is limited number of drugs are available to treat microbial infection that too have serious toxic effects the existing drugs has been suffering from the development of resistance and thus newer drugs are required with better activity profile. In this paper synthesis of 1,3,4- oxadiazole derivative with precursor salicylic acid and perform an antifungal activity.

Synthesis and Antifungal Activity Evaluation of 1-sulfonyl-1,2,3-triazoles

2021 ◽  
Author(s):  
Juan José García-Vanegas ◽  
Janeth Rodríguez-Florencio ◽  
Damián David Cifuentes-Castañeda ◽  
Hugo Mendieta-Zerón ◽  
Sergio Pavón-Romero ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Activity Evaluation
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