Photophysical properties of heavy atom containing tetrasulfonyl phthalocyanines as possible photosensitizers in photodynamic therapy

2021 ◽  
Author(s):  
Bruna Clara De Simone ◽  
Marta Erminia Alberto ◽  
Nino Russo ◽  
Marirosa Toscano
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Heavy Atom

Femtosecond Intersystem Crossing to the Reactive Triplet State of the 2,6-Dithiopurine Skin Cancer Photosensitizer

2021 ◽  
Author(s):  
Luis A. Ortiz-Rodríguez ◽  
Sean J. Hoehn ◽  
Chris Acquah ◽  
Nadia Abbass ◽  
Lidia Waidmann ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Triplet State ◽  
Photophysical Properties ◽  
Heavy Atom ◽  
Strong Absorption ◽  
Intersystem Crossing ◽  
Ultraviolet A

Site-selected sulfur-substituted nucleobases are a class of all organic, heavy-atom-free photosensitizers for photodynamic therapy applications that exhibit excellent photophysical properties such as strong absorption in the ultraviolet-A region of the...

Excitation energies, singlet–triplet energy gaps, spin–orbit matrix elements and heavy atom effects in BOIMPYs as possible photosensitizers for photodynamic therapy: a computational investigation

2018 ◽  
Vol 20 (4) ◽  
pp. 2656-2661 ◽  
Author(s):  
Bruna Clara De Simone ◽  
Gloria Mazzone ◽  
Nino Russo ◽  
Emilia Sicilia ◽  
Marirosa Toscano
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Heavy Atom ◽  
Spin Orbit ◽  
Matrix Elements ◽  
Computational Investigation ◽  
Triplet Energy ◽  
Excitation Energies ◽  
Halogen Atoms ◽  
Energy Gaps

Introduction of halogen atoms in different amounts and positions into the BOIMPY skeleton significantly affects its photophysical properties.

The heavy atom effect on Zn(ii) phthalocyanine derivatives: a theoretical exploration of the photophysical properties

2015 ◽  
Vol 17 (36) ◽  
pp. 23595-23601 ◽  
Author(s):  
Marta E. Alberto ◽  
Bruna C. De Simone ◽  
Gloria Mazzone ◽  
Emilia Sicilia ◽  
Nino Russo
Keyword(s):  
Photodynamic Therapy ◽  
Electronic Spectra ◽  
Photophysical Properties ◽  
Heavy Atom ◽  
Spin Orbit ◽  
Matrix Elements ◽  
Triplet Energy ◽  
Energy Gaps ◽  
P Absorption ◽  
Atom Effect

Absorption electronic spectra, singlet–triplet energy gaps and spin–orbit matrix elements have been computed at DFT and TDDFT levels of theory for a series of substituted Zn(ii)-phthalocyanines (ZnPcs), recently proposed as potential photosensitizers in photodynamic therapy (PDT).

scholarly journals Twisted Bodipy Derivative: Intersystem Crossing, Electron Spin Polarization and Application As a Novel Photodynamic Therapy Reagent

2021 ◽  
Author(s):  
Yu Dong ◽  
Prashant Kumar ◽  
Partha Maity ◽  
Ivan Kurganskii ◽  
Shujing Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Triplet State ◽  
Spin Polarization ◽  
Electron Spin ◽  
Photophysical Properties ◽  
Heavy Atom ◽  
Electron Spin Polarization ◽  
Intersystem Crossing

The photophysical properties of a heavy atom-free Bodipy derivative with twisted π-conjugation framework were studied. Efficient intersystem crossing (ISC. Quantum yield: 56%) and exceptionally long-lived triplet state wereobserved (4.5 ms....

scholarly journals The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

2018 ◽  
Vol 9 ◽  
pp. 2960-2967 ◽  
Author(s):  
Jan Hynek ◽  
Sebastian Jurík ◽  
Martina Koncošová ◽  
Jaroslav Zelenka ◽  
Ivana Křížová ◽  
...  
Keyword(s):  
Inorganic Chemistry ◽  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Biological Applications ◽  
Nanoparticle Surface ◽  
Metal Organic ◽  
Unsaturated Metal Sites ◽  
First Time

Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin. The nanoICR-2/porphyrin composites retain part of the free porphyrins photophysical properties, while the photodynamic efficacy is strongly affected by the R substituent at the porphyrin phosphinate groups. Thus, phosphinatophenylporphyrin with phenyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake.

Sign in / Sign up

Export Citation Format

Share Document