Is inhibition process better described with MD(QM/MM) simulations? The case of urokinase type plasminogen activator inhibitors

Florent Barbault; François Maurel

doi:10.1002/jcc.21983

Is inhibition process better described with MD(QM/MM) simulations? The case of urokinase type plasminogen activator inhibitors

Journal of Computational Chemistry ◽

10.1002/jcc.21983 ◽

2012 ◽

Vol 33 (6) ◽

pp. 607-616 ◽

Cited By ~ 7

Author(s):

Florent Barbault ◽

François Maurel

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Inhibition Process

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4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00312-8 ◽

2002 ◽

Vol 12 (15) ◽

pp. 2023-2026 ◽

Cited By ~ 14

Author(s):

Jeffrey R Spencer ◽

Danny McGee ◽

Darin Allen ◽

Bradley A Katz ◽

Christine Luong ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator

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Immunohistochemical localization of urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in early human implantation sites

International Journal of Gynecology & Obstetrics ◽

10.1016/0020-7292(94)90376-x ◽

1994 ◽

Vol 47 (2) ◽

pp. 195-195

Author(s):

G.E. Hofmann ◽

I. Glatstein ◽

F. Schatz ◽

D. Heller ◽

L. Deligdisch

Keyword(s):

Plasminogen Activator ◽

Immunohistochemical Localization ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Implantation Sites ◽

Early Human ◽

Human Implantation

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2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00311-6 ◽

2002 ◽

Vol 12 (15) ◽

pp. 2019-2022 ◽

Cited By ~ 21

Author(s):

Richard L. Mackman ◽

Hon C. Hui ◽

J.Guy Breitenbucher ◽

Bradley A. Katz ◽

Christine Luong ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator

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Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines†

Journal of Medicinal Chemistry ◽

10.1021/jm061066t ◽

2007 ◽

Vol 50 (10) ◽

pp. 2341-2351 ◽

Cited By ~ 38

Author(s):

Paul V. Fish ◽

Christopher G. Barber ◽

David G. Brown ◽

Richard Butt ◽

Michael G. Collis ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator

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Is there a role for urokinase-type plasminogen activator inhibitors as maintenance therapy in patients with ovarian cancer?

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2016.06.002 ◽

2017 ◽

Vol 43 (2) ◽

pp. 252-257 ◽

Cited By ~ 7

Author(s):

P.A. van Dam ◽

A. Coelho ◽

C. Rolfo

Keyword(s):

Ovarian Cancer ◽

Maintenance Therapy ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator

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Prognostic value of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in breast carcinomas

British Journal of Cancer ◽

10.1038/bjc.1994.74 ◽

1994 ◽

Vol 69 (2) ◽

pp. 398-405 ◽

Cited By ~ 104

Author(s):

C Bouchet ◽

F Spyratos ◽

PM Martin ◽

K Hacène ◽

A Gentile ◽

...

Keyword(s):

Plasminogen Activator ◽

Prognostic Value ◽

Breast Carcinomas ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Pai 1

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Immunohistochemical localization of urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in early human implantation sites

American Journal of Obstetrics and Gynecology ◽

10.1016/s0002-9378(94)70246-2 ◽

1994 ◽

Vol 170 (2) ◽

pp. 671-676 ◽

Cited By ~ 57

Author(s):

Glen E. Hofmann ◽

Isaac Glatstein ◽

Frederick Schatz ◽

Debra Heller ◽

Liana Deligdisch

Keyword(s):

Plasminogen Activator ◽

Immunohistochemical Localization ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Implantation Sites ◽

Early Human ◽

Human Implantation

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Insight into the Structural Requirements of Urokinase-Type Plasminogen Activator Inhibitors Based on 3D QSAR CoMFA/CoMSIA Models

Journal of Medicinal Chemistry ◽

10.1021/jm050149r ◽

2006 ◽

Vol 49 (2) ◽

pp. 475-489 ◽

Cited By ~ 7

Author(s):

Bhoomendra A. Bhongade ◽

Andanappa K. Gadad

Keyword(s):

Plasminogen Activator ◽

3D Qsar ◽

Structural Requirements ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Insight Into

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Urokinase-type plasminogen activator and plasminogen activator inhibitors (PAI-1 and PAI-2) in extracts of invasive cervical carcinoma and precursor lesions

European Journal of Cancer ◽

10.1016/s0959-8049(97)10038-7 ◽

1998 ◽

Vol 34 (4) ◽

pp. 566-569 ◽

Cited By ~ 27

Author(s):

A Daneri-Navarro ◽

G Macias-Lopez ◽

A Oceguera-Villanueva ◽

S Del Toro-Arreola ◽

A Bravo-Cuellar ◽

...

Keyword(s):

Plasminogen Activator ◽

Cervical Carcinoma ◽

Precursor Lesions ◽

Invasive Cervical Carcinoma ◽

Plasminogen Activator Inhibitors ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Pai 1

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EXPRESSION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR, UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR AND PLASMINOGEN ACTIVATOR INHIBITORS IN PATIENTS WITH RENAL CELL CARCINOMA: CORRELATION WITH TUMOR ASSOCIATED MACROPHAGE AND PROGNOSIS

The Journal of Urology ◽

10.1097/01.ju.0000165150.46006.92 ◽

2005 ◽

Vol 174 (2) ◽

pp. 461-465 ◽

Cited By ~ 44

Author(s):

KOJIRO OHBA ◽

YASUYOSHI MIYATA ◽

SHIGERU KANDA ◽

SHIGEHIKO KOGA ◽

TOMAYOSHI HAYASHI ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Plasminogen Activator ◽

Renal Cell ◽

Plasminogen Activator Inhibitors ◽

Tumor Associated Macrophage ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Plasminogen Activator Receptor

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