The importance of aromatic-type interactions in serotonin synthesis: Protein-ligand interactions in tryptophan hydroxylase and aromatic amino acid decarboxylase

2009 ◽  
Vol 30 (7) ◽  
pp. 1111-1115 ◽  
Author(s):  
Laura R. Hofto ◽  
Caroline E. Lee ◽  
Mauricio Cafiero
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Tryptophan Hydroxylase ◽  
Acid Decarboxylase ◽  
Serotonin Synthesis ◽  
Amino Acid Decarboxylase ◽  
Aromatic Amino Acid Decarboxylase ◽  
Protein Ligand Interactions ◽  
Ligand Interactions

Inhibitors binding to L-aromatic amino acid decarboxylase

Life Sciences ◽  
1982 ◽  
Vol 31 (14) ◽  
pp. 1519-1524 ◽  
Author(s):  
Erminia Barboni ◽  
Carla Borri Voltattorni ◽  
Maria D'Erme ◽  
Anna Fiori ◽  
Alba Minelli ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Acid Decarboxylase ◽  
Amino Acid Decarboxylase ◽  
Aromatic Amino Acid Decarboxylase

Influence of an Aromatic Amino Acid Decarboxylase Inhibitor on GTP Cyclohydrolase I Activity in the Rat Brain

Pteridines ◽  
1997 ◽  
Vol 8 (3) ◽  
pp. 206-210
Author(s):  
Hideo Sakamoto ◽  
Ko Fujita ◽  
Hiroshi Kuzuya
Keyword(s):  
Amino Acid ◽  
Medulla Oblongata ◽  
Aromatic Amino Acid ◽  
Acid Decarboxylase ◽  
Gtp Cyclohydrolase I ◽  
Gtp Cyclohydrolase ◽  
Amino Acid Decarboxylase ◽  
Aromatic Amino Acid Decarboxylase ◽  
Biopterin Synthesis ◽  
Pons Medulla

Summary Based on the hypothesis that catecholamine decreases may cause increases in biopterin, we measured the GTP cyclohydrolase I(GTPCH-I) activity and biopterin content in the cerebral cortex, midbrain/diencephalon, cerebeilum, pons/medulla oblongata, striatum , and hippocampus of brains from rats given NSDlOIS, an inhibitor for aromatic amino acid decarboxylase . The catecholamine contents decreased in all the regions tested. The changes in the GTPCH -I activity and bioptcrin content were different among the regions; they decreased in some regions contrary to expectations and increased in other regions. However, either the enzyme activity or biopterin content increased in the midbrain/ diencephalon and pons/ medulla oblongata, in which similar levels of catecholamines, GTPCH -I activity and biopterin were detected. These results suggest that for the midbrain/diencephalon and pons/medulla oblongata the surmise that a decrease in catecholamines causes an increase in the biopterin synthesis may be correct.

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