The prominence of potential biomarkers in the diagnosis and management of hepatocellular carcinoma: Current scenario and future anticipation

2021 ◽  
Author(s):  
Ishfaq Hassan Mir ◽  
K. C. Jyothi ◽  
Chinnasamy Thirunavukkarasu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnosis And Management ◽  
Current Scenario ◽  
Potential Biomarkers

scholarly journals Comprehensive analyses of competing endogenous RNA networks reveal potential biomarkers for predicting hepatocellular carcinoma recurrence

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ping Yan ◽  
Zuotian Huang ◽  
Tong Mou ◽  
Yunhai Luo ◽  
Yanyao Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Malignant Tumors ◽  
Expression Profiles ◽  
Clinical Information ◽  
Gene Expression Omnibus ◽  
The Cancer Genome Atlas ◽  
High Rate ◽  
Competing Endogenous Rna ◽  
Tissue Samples ◽  
Potential Biomarkers

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common and deadly malignant tumors, with a high rate of recurrence worldwide. This study aimed to investigate the mechanism underlying the progression of HCC and to identify recurrence-related biomarkers. Methods We first analyzed 132 HCC patients with paired tumor and adjacent normal tissue samples from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs). The expression profiles and clinical information of 372 HCC patients from The Cancer Genome Atlas (TCGA) database were next analyzed to further validate the DEGs, construct competing endogenous RNA (ceRNA) networks and discover the prognostic genes associated with recurrence. Finally, several recurrence-related genes were evaluated in two external cohorts, consisting of fifty-two and forty-nine HCC patients, respectively. Results With the comprehensive strategies of data mining, two potential interactive ceRNA networks were constructed based on the competitive relationships of the ceRNA hypothesis. The ‘upregulated’ ceRNA network consists of 6 upregulated lncRNAs, 3 downregulated miRNAs and 5 upregulated mRNAs, and the ‘downregulated’ network includes 4 downregulated lncRNAs, 12 upregulated miRNAs and 67 downregulated mRNAs. Survival analysis of the genes in the ceRNA networks demonstrated that 20 mRNAs were significantly associated with recurrence-free survival (RFS). Based on the prognostic mRNAs, a four-gene signature (ADH4, DNASE1L3, HGFAC and MELK) was established with the least absolute shrinkage and selection operator (LASSO) algorithm to predict the RFS of HCC patients, the performance of which was evaluated by receiver operating characteristic curves. The signature was also validated in two external cohort and displayed effective discrimination and prediction for the RFS of HCC patients. Conclusions In conclusion, the present study elucidated the underlying mechanisms of tumorigenesis and progression, provided two visualized ceRNA networks and successfully identified several potential biomarkers for HCC recurrence prediction and targeted therapies.

The effect of key DNA methylation in different regions on gene expression in hepatocellular carcinoma

2021 ◽  
Author(s):  
Yu-Xian Liu ◽  
Qian-Zhong Li ◽  
Yan-Ni Cao
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Prognostic Factors ◽  
Potential Biomarkers

Four genes related to DNA methylation were found to be independent prognostic factors and potential biomarkers for hepatocellular carcinoma.

scholarly journals Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

Neoplasma ◽  
2012 ◽  
Vol 60 (02) ◽  
pp. 135-142 ◽  
Author(s):  
J. QI ◽  
J. WANG ◽  
H. KATAYAMA ◽  
S. SEN ◽  
S. M. LIU
Keyword(s):  
Hepatocellular Carcinoma ◽  
Circulating Micrornas ◽  
Potential Biomarkers

scholarly journals Long Non-Coding RNAs: Potential Biomarkers and Targets for Hepatocellular Carcinoma Therapy and Diagnosis

2021 ◽  
Vol 17 (1) ◽  
pp. 220-235
Author(s):  
Donghong Yuan ◽  
Yu Chen ◽  
Xiaobing Li ◽  
Jing Li ◽  
Yueshui Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Non Coding Rnas ◽  
Therapy And Diagnosis ◽  
Potential Biomarkers

scholarly journals Saudi Guidelines for the Diagnosis and Management of Hepatocellular Carcinoma: Technical Review and Practice Guidelines

2012 ◽  
Vol 32 (2) ◽  
pp. 174-199 ◽  
Author(s):  
Ayman A. Abdo ◽  
Mazen Hassanain ◽  
AbdulRahman AlJumah ◽  
Ashwaq Al Olayan ◽  
Faisal M. Sanai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Practice Guidelines ◽  
Diagnosis And Management ◽  
Technical Review

Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma

2018 ◽  
Vol 12 (3) ◽  
pp. 245-256 ◽  
Author(s):  
Mahmoud A Ali ◽  
Marwa Matboli ◽  
Nashwa El-Khazragy ◽  
Osama Saber ◽  
Sarah El-Nakeep ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mrna Expression ◽  
Potential Biomarkers

Management of hepatocellular carcinoma

2021 ◽  
Vol 4 (1) ◽  
pp. 19-25
Author(s):  
Salem Youssef Mohamed
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Liver Cancer ◽  
Early Diagnosis ◽  
Primary Liver Cancer ◽  
Screening Programs ◽  
Diagnosis And Management

Hepatocellular carcinoma (HCC) is a heterogeneous disease that develops most of the time on diseases liver. Early diagnosis and management are the best options for the patients, so screening programs are mandatory for those who are at risk of the development of HCC. Despite the challenge of management of HCC, there is hopeful management for HCC as the field of primary liver cancer has moved quickly

Current approaches to the diagnosis and management of hepatocellular carcinoma

2005 ◽  
Vol 5 (1) ◽  
pp. 1-13 ◽  
Author(s):  
J. F. Perry ◽  
H. Poustchi ◽  
J. George ◽  
G. C. Farrell ◽  
G. W. McCaughan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnosis And Management
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