A new functional role of mitochondria‐anchored protein ligase in peroxisome morphology in mammalian cells

2021 ◽  
Author(s):  
Abhishek Mohanty ◽  
Rodolfo Zunino ◽  
Vincent Soubannier ◽  
Shilpa Dilipkumar
Keyword(s):  
Mammalian Cells ◽  
Functional Role

scholarly journals Expression and Functional Role of the γ Subunit of the Na,K-ATPase in Mammalian Cells

1999 ◽  
Vol 274 (18) ◽  
pp. 12252-12256 ◽  
Author(s):  
Alex G. Therien ◽  
Steven J. D. Karlish ◽  
Rhoda Blostein
Keyword(s):  
Mammalian Cells ◽  
Functional Role ◽  
Γ Subunit

scholarly journals The functional role of Cdc6 in S–G2/M in mammalian cells

EMBO Reports ◽  
2006 ◽  
Vol 7 (4) ◽  
pp. 425-430 ◽  
Author(s):  
Eric Lau ◽  
Changjun Zhu ◽  
Robert T Abraham ◽  
Wei Jiang
Keyword(s):  
Mammalian Cells ◽  
Functional Role

scholarly journals Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2716
Author(s):  
Matteo Trovato ◽  
Vibha Patil ◽  
Maja Gehre ◽  
Kyung Min Noh
Keyword(s):  
Mammalian Cells ◽  
Functional Role ◽  
Histone Variant ◽  
Model Organisms ◽  
Post Translational Modification ◽  
Mammalian Development ◽  
Histone 3 ◽  
Oncogenic Mutations ◽  
Health And Disease

The systematic mutation of histone 3 (H3) genes in model organisms has proven to be a valuable tool to distinguish the functional role of histone residues. No system exists in mammalian cells to directly manipulate canonical histone H3 due to a large number of clustered and multi-loci histone genes. Over the years, oncogenic histone mutations in a subset of H3 have been identified in humans, and have advanced our understanding of the function of histone residues in health and disease. The oncogenic mutations are often found in one allele of the histone variant H3.3 genes, but they prompt severe changes in the epigenetic landscape of cells, and contribute to cancer development. Therefore, mutation approaches using H3.3 genes could be relevant to the determination of the functional role of histone residues in mammalian development without the replacement of canonical H3 genes. In this review, we describe the key findings from the H3 mutation studies in model organisms wherein the genetic replacement of canonical H3 is possible. We then turn our attention to H3.3 mutations in human cancers, and discuss H3.3 substitutions in the N-terminus, which were generated in order to explore the specific residue or associated post-translational modification.

Expression and functional role of c-Kit and erbB2 in human hepatoblastoma.

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
B Steiger ◽  
I Leuschner ◽  
D Denkhaus ◽  
D von Schweinitz ◽  
T Pietsch
Keyword(s):  
Functional Role
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