MiR‐145 inhibits the migration and invasion of papillary thyroid carcinoma cells through NF‐κB pathway regulation

2020 ◽  
Vol 121 (5-6) ◽  
pp. 3325-3332 ◽  
Author(s):  
Gengyu Chen ◽  
Ying Gao ◽  
Gangpu Wang ◽  
Guofeng Dai ◽  
Li Tong
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Papillary Thyroid ◽  
Pathway Regulation

scholarly journals Expression of heparanase regulates cell proliferation, apoptosis, migration and invasion in vitro in papillary thyroid carcinoma cells with multiple signaling pathways involved

2019 ◽  
Author(s):  
Chuanjia Yang ◽  
Siyang Zhang ◽  
Xiaoying Chang ◽  
Yonglian Huang ◽  
Dongxu Cui ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Signaling Pathways ◽  
Signaling Molecules ◽  
Carcinoma Cells ◽  
Biological Behavior ◽  
Migration And Invasion ◽  
Papillary Thyroid ◽  
Multiple Signaling

Abstract Background Heparanase (HPSE) is an endo-β-D-glucuronidase, which is found overexpressed in various human cancers. The purpose of our work was to investigate the possible role of HPSE and the involved signaling molecules in the development of papillary thyroid carcinoma. Methods In this study, the expression plasmid of HPSE and RNA interference with shRNA specific for HPSE were used to elucidate the effects of HPSE on proliferation, apoptosis, migration and invasion in papillary thyroid carcinoma cells of B-CPAP. The probable downstream signaling molecules of HPSE were also explored. Results The results showed that upregulation of HPSE significantly promoted cell proliferation, migration and invasion of B-CPAP cells, and interfered with cell apoptosis. On the contrary, knockdown of HPSE exhibited the opposite effects. Compared with the parental cells, HPSE silencing cells showed attenuated capabilities of proliferation, migration and invasion, yet the apoptotic rate of transfected cells was increased. The activations of various signaling molecules correlated with cell biological behavior were found to be regulated by HPSE upregulation or knockdown. Conclusions Our results suggested that HPSE probably contributed to the progression and metastasis of papillary thyroid carcinoma, which were associated with multiple signaling pathways. HPSE could be a potent molecular target for the therapeutic strategy of papillary thyroid carcinoma.

scholarly journals MiRNA-146b-5p upregulates migration and invasion of different Papillary Thyroid Carcinoma cells

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Cilene Rebouças Lima ◽  
Murilo Vieira Geraldo ◽  
Cesar Seigi Fuziwara ◽  
Edna Teruko Kimura ◽  
Marinilce Fagundes Santos
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Papillary Thyroid

scholarly journals Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells

2014 ◽  
Vol 13 (1) ◽  
pp. 160 ◽  
Author(s):  
Gennaro Di Maro ◽  
Paolo Salerno ◽  
Kristian Unger ◽  
Francesca Orlandella ◽  
Mario Monaco ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Papillary Thyroid

scholarly journals Silencing of FoxM1 blocks growth, migration and invasion of papillary thyroid carcinoma cells

2019 ◽  
Author(s):  
Xiaotao Wang ◽  
Yongkui Zhao ◽  
Mingxin Cui ◽  
Jianli Chen ◽  
Wenbin Cao ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Papillary Thyroid
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