LRP6 regulates Rab7‐mediated autophagy through the Wnt/β‐catenin pathway to modulate trophoblast cell migration and invasion

2019 ◽  
Vol 121 (2) ◽  
pp. 1599-1609 ◽  
Author(s):  
Lei Li ◽  
Wei Peng ◽  
Qian Zhou ◽  
Ji‐Peng Wan ◽  
Xie‐Tong Wang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Trophoblast Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

Vaccinium angustifolium (lowbush blueberry) leaf extract increases extravillous trophoblast cell migration and invasion in vitro

2018 ◽  
Vol 32 (4) ◽  
pp. 705-714 ◽  
Author(s):  
Christina Ly ◽  
Jonathan Ferrier ◽  
Jeremiah Gaudet ◽  
Julien Yockell-Lelièvre ◽  
John Thor Arnason ◽  
...  
Keyword(s):  
Cell Migration ◽  
Leaf Extract ◽  
Trophoblast Cell ◽  
Extravillous Trophoblast ◽  
Migration And Invasion ◽  
Vaccinium Angustifolium ◽  
Cell Migration And Invasion ◽  
Lowbush Blueberry

Dysregulation of HDAC9 Represses Trophoblast Cell Migration and Invasion Through TIMP3 Activation in Preeclampsia

2019 ◽  
Vol 32 (5) ◽  
pp. 515-523 ◽  
Author(s):  
Dandan Xie ◽  
Jingping Zhu ◽  
Qianqian Liu ◽  
Jun Li ◽  
Mengjiu Song ◽  
...  
Keyword(s):  
Cell Migration ◽  
Trophoblast Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals Down-regulation of microRNA-34a-5p promotes trophoblast cell migration and invasion via targetting Smad4

2019 ◽  
Vol 39 (2) ◽  
Author(s):  
Fang Xue ◽  
Jing Yang ◽  
Qirong Li ◽  
Haibin Zhou
Keyword(s):  
Cell Migration ◽  
Expression Profiles ◽  
Trophoblast Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Invasion And Migration ◽  
Luciferase Activity Assay ◽  
Cell Invasiveness ◽  
And Migration ◽  
Mirnas Expression

Abstract Trophoblastic dysfunction, such as insufficient migration and invasion, is well-known to be correlated with preeclampsia (PE). Recently, microRNAs (miRNAs) have been implicated in diverse biological processes and human diseases, including PE. However, the expression and functions of miRNAs in the progression of PE, especially in the regulation of trophoblast cell migration and invasion remain largely unclear. Here, we compared the miRNAs expression profiles of PE patients with healthy controls using microarray assay and chose a significant increased miRNA-miR-34a-5p for further investigation. Overexpression of miR-34a-5p dramatically reduced migration and invasion in trophoblast HTR-8/SVneo cells, whereas enhanced by its inhibitor. Luciferase activity assay showed that miR-34a-5p directly target Smad family member 4 (Smad4), which is associated with cancer cell invasiveness and metastasis. We also found that Smad4 was down-regulated in PE patients, and an inverse relationship between Smad4 and miR-34a-5p expression levels was observed in placental tissues from PE patients. Further study showed that knockdown of Smad4 effectively attenuated the promoting effects of miR-34a-5p inhibition on the migration and invasion of HTR-8/SVneo cells. Taken together, these findings suggest that inhibition of miR-34a-5p improves invasion and migration of trophoblast cells by directly targetting Smad4, which indicated the potential of miR-34a-5p as a therapeutic target against PE.

scholarly journals LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal–maternal interface

2014 ◽  
Vol 5 (8) ◽  
pp. e1396-e1396 ◽  
Author(s):  
S Liu ◽  
J Wang ◽  
H-M Qin ◽  
X-M Yan ◽  
X-S Yang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Trophoblast Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion
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