Guanylate‐binding protein‐2 inhibits colorectal cancer cell growth and increases the sensitivity to paclitaxel of paclitaxel‐resistant colorectal cancer cells by interfering Wnt signaling

2019 ◽  
Vol 121 (2) ◽  
pp. 1250-1259 ◽  
Author(s):  
Jing Wang ◽  
Hui Min ◽  
Bin Hu ◽  
Xiaorong Xue ◽  
Yufan Liu
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Binding Protein ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Growth ◽  
Colorectal Cancer Cells ◽  
Guanylate Binding Protein

scholarly journals Onion Peel Extract Inhibits Cancer Cell Growth and Progression through the Roles of L1CAM, NF-κB, and Angiogenesis in HT-29 Colorectal Cancer Cells

2021 ◽  
Vol 26 (3) ◽  
pp. 330-337
Author(s):  
Tamonwan Uttarawichien ◽  
Wilunplus Khumsri ◽  
Prasit Suwannalert ◽  
Nathawut Sibmooh ◽  
Witchuda Payuhakrit
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Onion Peel ◽  
Colorectal Cancer Cells ◽  
Onion Peel Extract ◽  
Ht 29 ◽  
Peel Extract

Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth

2011 ◽  
Vol 71 (1) ◽  
pp. 197-205 ◽  
Author(s):  
Jo Waaler ◽  
Ondrej Machon ◽  
Jens Peter von Kries ◽  
Steven Ray Wilson ◽  
Elsa Lundenes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Wnt Signaling ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Canonical Wnt Signaling ◽  
Cancer Cell Growth ◽  
Canonical Wnt

scholarly journals In Hyperthermia Increased ERK and WNT Signaling Suppress Colorectal Cancer Cell Growth

Cancers ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 49 ◽  
Author(s):  
Michael Bordonaro ◽  
Senji Shirasawa ◽  
Darina Lazarova
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Wnt Signaling ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1

2020 ◽  
Vol 21 (12) ◽  
pp. 4514 ◽  
Author(s):  
Keitaro Takahashi ◽  
Mikihiro Fujiya ◽  
Hiroaki Konishi ◽  
Yuki Murakami ◽  
Takuya Iwama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Mrna Expression ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Colorectal Cancer Cells ◽  
Cell Progression ◽  
Sphingosine 1 Phosphate ◽  
Nuclear Ribonucleoprotein

The oncogenic properties of heterogeneous nuclear ribonucleoprotein H1 (hnRNP H1) have been reported, although the tumor-promoting mechanism remains unclear. We herein report the mechanism underlying colorectal cancer cell progression mediated by hnRNP H1. The growth of colorectal cancer cells was suppressed by hnRNP H1 downregulation. A terminal deoxynucleotidyl transferase dUTP nick-end labeling assay revealed the anti-apoptotic effect of hnRNP H1 in colorectal cancer cells. An RNA immunoprecipitation assay revealed that hnRNP H1 bound to sphingosine-1-phosphate lyase 1 (SGPL1). Reverse transcription-polymerase chain reaction revealed the high expression of hnRNP H1 mRNA in colorectal cancer cells and Spearman’s rank correlation coefficient showed a strong positive correlation between hnRNP H1 mRNA and SGPL1 mRNA. An siRNA of hnRNP H1 decreased SGPL1 mRNA expression in colorectal cancer cells, but not in non-tumorous cells. These findings suggested that hnRNP H1 increased SGPL1 mRNA expression specifically in cancer cells through direct binding. Targeted knockdown of hnRNP H1 or SGPL1 with siRNAs upregulated p53 phosphorylation and p53-associated molecules, resulting in cell growth inhibition, while hnRNP H1 upregulated the mRNA of SGPL1 and inhibited p53 activation, thereby promoting tumor cell growth. This is a novel mechanism underlying colorectal cancer cell progression mediated by hnRNP H1–SGPL1 mRNA stabilization.

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