miR‐496 remedies hypoxia reoxygenation–induced H9c2 cardiomyocyte apoptosis via Hook3‐targeted PI3k/Akt/mTOR signaling pathway activation

2019 ◽  
Vol 121 (1) ◽  
pp. 698-712
Author(s):  
Yongping Jin ◽  
Shimao Ni
Keyword(s):  
Signaling Pathway ◽  
Mtor Signaling ◽  
Cardiomyocyte Apoptosis ◽  
Mtor Signaling Pathway ◽  
Pathway Activation ◽  
Hypoxia Reoxygenation

scholarly journals Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Bu-gao Zhou ◽  
Hai-mei Zhao ◽  
Xiu-yun Lu ◽  
Xin Wang ◽  
Yong Zou ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathway ◽  
Mammalian Target Of Rapamycin ◽  
Liver Weight ◽  
Mtor Signaling ◽  
Hepatoprotective Effect ◽  
Mtor Signaling Pathway ◽  
Gamma Glutamyl Transpeptidase ◽  
Pathway Activation ◽  
Experimental Liver

The present study aimed to investigate the mechanism of hepatoprotective effect of Erzhi Pill (EZP) on the liver injury via observing TSC/mTOR signaling pathway activation. The experimental liver injury was induced by 2-acetylaminofluorene (2-AAF) treatment combined with partial hepatectomy (PH). EZP treated 2-AAF/PH-induced liver injury by the therapeutic and prophylactic administration. After the administration of EZP, the activities of aspartic transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AKP), and gamma-glutamyl transpeptidase (γ-GT) were decreased, followed by the decreased levels of hepatocyte apoptosis and caspase-3 expression. However, the secretion of albumin, liver weight, and index of liver weight were elevated. Microscopic examination showed that EZP restored pathological liver injury. Meanwhile, Rheb and mammalian target of rapamycin (mTOR) activation were suppressed, and tuberous sclerosis complex (TSC) expression was elevated in liver tissues induced by 2-AAF/PHx and accompanied with lower-expression of Bax, Notch1, p70S6K, and 4E-EIF and upregulated levels of Bcl-2 and Cyclin D. Hepatoprotective effect of EZP was possibly realized via inhibiting TSC/mTOR signaling pathway to suppress excessive apoptosis of hepatocyte.

Exendin-4 attenuates cardiac hypertrophy via AMPK/mTOR signaling pathway activation

2015 ◽  
Vol 468 (1-2) ◽  
pp. 394-399 ◽  
Author(s):  
Yue Zhou ◽  
Xin He ◽  
Yili Chen ◽  
Yiyi Huang ◽  
Lingling Wu ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Pathway Activation
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