A novel regulatory role of TRAPPC9 in L‐plastin‐mediated osteoclast actin ring formation

2019 ◽  
Vol 121 (1) ◽  
pp. 284-298
Author(s):  
Nazar J. Hussein ◽  
Thomas Mbimba ◽  
Asaad A. Al‐Adlaan ◽  
Mohammad Y. Ansari ◽  
Fatima A. Jaber ◽  
...  
Keyword(s):  
Ring Formation ◽  
Regulatory Role ◽  
Actin Ring

Critical role of cortactin in actin ring formation and osteoclastic bone resorption

2006 ◽  
Vol 24 (5) ◽  
pp. 368-372 ◽  
Author(s):  
Takuma Matsubara ◽  
Akira Myoui ◽  
Fumiyo Ikeda ◽  
Kenji Hata ◽  
Hideki Yoshikawa ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Critical Role ◽  
Ring Formation ◽  
Osteoclastic Bone Resorption ◽  
Actin Ring

scholarly journals The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe

2003 ◽  
Vol 162 (5) ◽  
pp. 851-862 ◽  
Author(s):  
Robert H. Carnahan ◽  
Kathleen L. Gould
Keyword(s):  
Schizosaccharomyces Pombe ◽  
Actin Filaments ◽  
Critical Role ◽  
Ring Formation ◽  
Actin Nucleation ◽  
Actin Ring ◽  
Mutual Dependence ◽  
Family Protein

Cytokinetic actin ring (CAR) formation in Schizosaccharomyces pombe requires two independent actin nucleation pathways, one dependent on the Arp2/3 complex and another involving the formin Cdc12p. Here we investigate the role of the S. pombe Cdc15 homology family protein, Cdc15p, in CAR assembly and find that it interacts with proteins from both of these nucleation pathways. Cdc15p binds directly to the Arp2/3 complex activator Myo1p, which likely explains why actin patches and the Arp2/3 complex fail to be medially recruited during mitosis in cdc15 mutants. Cdc15p also binds directly to Cdc12p. Cdc15p and Cdc12p not only display mutual dependence for CAR localization, but also exist together in a ring-nucleating structure before CAR formation. The disruption of these interactions in cdc15 null cells is likely to be the reason for their complete lack of CARs. We propose a model in which Cdc15p plays a critical role in recruiting and coordinating the pathways essential for the assembly of medially located F-actin filaments and construction of the CAR.

Regulatory role of resistin on ovarian function

2014 ◽  
Author(s):  
Agnieszka Rak-Mardyla ◽  
Anna Wrobel ◽  
Eliza Drwal ◽  
Ewa Gregoraszczuk
Keyword(s):  
Ovarian Function ◽  
Regulatory Role
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