Silencing FUNDC1 alleviates chronic obstructive pulmonary disease by inhibiting mitochondrial autophagy and bronchial epithelium cell apoptosis under hypoxic environment

2019 ◽  
Vol 120 (10) ◽  
pp. 17602-17615 ◽  
Author(s):  
Wen Wen ◽  
Guoqing Yu ◽  
Wei Liu ◽  
Lei Gu ◽  
Jiahui Chu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cell Apoptosis ◽  
Bronchial Epithelium ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Epithelium Cell ◽  
Hypoxic Environment

scholarly journals Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease

2017 ◽  
Vol 124 ◽  
pp. 72-78 ◽  
Author(s):  
Sayantan Datta ◽  
Hae-Seong Nam ◽  
Masamichi Hayashi ◽  
Leonel Maldonado ◽  
Rachel Goldberg ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Epithelium ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Physiologic and histopathologic effects of targeted lung denervation in an animal model

2019 ◽  
Vol 126 (1) ◽  
pp. 67-76 ◽  
Author(s):  
James P. Hummel ◽  
Martin L. Mayse ◽  
Steve Dimmer ◽  
Philip J. Johnson
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Primary Source ◽  
Experimental Treatment ◽  
Bronchial Epithelium ◽  
Chronic Obstructive ◽  
Clinical Effects ◽  
Surface Cooling ◽  
Obstructive Pulmonary Disease ◽  
Long Acting

Parasympathetic efferent innervation of the lung is the primary source of lung acetylcholine. Inhaled long-acting anticholinergics improve lung function and symptoms in patients with chronic obstructive pulmonary disease. Targeted lung denervation (TLD), a bronchoscopic procedure intended to disrupt pulmonary parasympathetic inputs, is an experimental treatment for chronic obstructive pulmonary disease. The physiologic and histologic effects of TLD have not previously been assessed. Eleven sheep and two dogs underwent circumferential ablation of the main bronchi with simultaneous balloon surface cooling using a lung denervation system (Nuvaira, Inc., Minneapolis, MN). Changes in pulmonary air flow resistance were monitored before and following TLD. Four animals were assessed for the presence or abolishment of the sensory axon-mediated Hering-Breuer reflex before and following TLD. Six sheep were histologically evaluated 30 days post-TLD for the extent of lung denervation (axonal staining) and effect on peribronchial structures near the treatment site. No adverse clinical effects were seen in any treated animals. TLD produced a ~30% reduction in pulmonary resistance and abolished the sensory-mediated Hering-Breuer reflex. Axonal staining was consistently decreased 60% at 30 days after TLD. All treated airways exhibited 100% epithelial integrity. Damage to other peribronchial structures was minimal. Tissue 1 cm proximal and distal to the treatment was normal, and the esophagus and periesophageal vagus nerve branches were unaffected. TLD treatment effectively denervates the lung while protecting the bronchial epithelium and minimizing effects on peribronchial structures. NEW & NOTEWORTHY The feasibility of targeted lung denervation, a new minimally invasive therapy for obstructive lung disease, has been demonstrated in humans with preliminary clinical studies demonstrating improvement in symptoms, pulmonary function, and exercise capacity in patients with chronic obstructive pulmonary disease. This preclinical animal study demonstrates the ability of targeted lung denervation to disrupt vagal inputs to the lung and details its physiologic and histopathologic effects.

scholarly journals Neutrophils infiltrating bronchial epithelium in chronic obstructive pulmonary disease

1998 ◽  
Vol 92 (6) ◽  
pp. 863-870 ◽  
Author(s):  
A. Pesci ◽  
M. Majori ◽  
A. Cuomo ◽  
N. Borciani ◽  
S. Bertacco ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Epithelium ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156009 ◽  
Author(s):  
Helen M. Rigden ◽  
Ahmad Alias ◽  
Thomas Havelock ◽  
Rory O'Donnell ◽  
Ratko Djukanovic ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Squamous Metaplasia ◽  
Bronchial Epithelium ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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