Identification of Nrf2/STAT3 axis in induction of apoptosis through sub‐G 1 cell cycle arrest mechanism in HT‐29 colon cancer cells

2019 ◽  
Vol 120 (8) ◽  
pp. 14035-14043 ◽  
Author(s):  
Issa Tajmohammadi ◽  
Jamal Mohammadian ◽  
Mehdi Sabzichi ◽  
Shiva Mahmuodi ◽  
Mina Ramezani ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Cycle Arrest ◽  
Induction Of Apoptosis ◽  
Ht 29

Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells

2009 ◽  
Vol 274 (2) ◽  
pp. 299-304 ◽  
Author(s):  
Astrid Bernhaus ◽  
Monika Fritzer-Szekeres ◽  
Michael Grusch ◽  
Philipp Saiko ◽  
Georg Krupitza ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Acid Derivative ◽  
Phenolic Acid ◽  
Colon Cancer Cells ◽  
Cycle Arrest ◽  
Ht 29

Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

2014 ◽  
Vol 156 ◽  
pp. 277-289 ◽  
Author(s):  
Soheil Zorofchian Moghadamtousi ◽  
Hamed Karimian ◽  
Elham Rouhollahi ◽  
Mohammadjavad Paydar ◽  
Mehran Fadaeinasab ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Annona Muricata ◽  
Colon Cancer Cells ◽  
Cycle Arrest ◽  
Hct 116 ◽  
G1 Cell Cycle Arrest ◽  
Ht 29

Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest

2002 ◽  
Vol 38 (18) ◽  
pp. 2446-2454 ◽  
Author(s):  
G Murillo ◽  
G.I Salti ◽  
J.W Kosmeder II ◽  
J.M Pezzuto ◽  
R.G Mehta
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Cycle Arrest ◽  
Induction Of Apoptosis

scholarly journals Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29

Foods ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 300 ◽  
Author(s):  
Hanaa Zbakh ◽  
Eva Zubía ◽  
Carolina De Los Reyes ◽  
José M. Calderón-Montaño ◽  
Virginia Motilva
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Brown Seaweed ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Cycle Arrest ◽  
Ht 29

Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy. However, due to the side effects and the emergence of drug resistance, the search for new anticancer agents, pharmacologically safe and effective, is needed. In the present study, we have investigated the anticancer effects of eight algal meroterpenoids (AMTs, 1-8) isolated from the brown seaweed Cystoseira usneoides and their underlying mechanisms of action using HT-29, a highly metastatic human colon cancer cell line. All the tested meroterpenoids inhibited the growth of HT-29 malignant cells and were less toxic towards non-cancer colon cells, with the AMTs 1 and 5 exhibiting selectivity indexes of 5.26 and 5.23, respectively. Treatment of HT-29 cells with the AMTs 1, 2, 3, 4, 5, and 7 induced cell cycle arrest in G2/M phase and, in some instances, apoptosis (compounds 2, 3, and 5). Compounds 1-8 also exhibited significant inhibitory effects on the migration and/or invasion of colon cancer cells. Mechanistic analysis demonstrated that the AMTs 1, 2, 5, 6, 7, and 8 reduced phosphorylation levels of extracellular signal-regulated kinase (ERK) and the AMTs 2, 3, 4, 5, 7, and 8 decreased phosphorylation of c-JUN N-terminal kinase (JNK). Moreover, the AMTs 1, 2, 3, 4, 7, and 8 inhibited phosphorylation levels of protein kinase B (AKT) in colon carcinoma cells. These results provide new insights into the mechanisms and functions of the meroterpenoids of C. usneoides, which exhibit an anticancer effect on HT-29 colon cancer cells by inducing cell cycle arrest and apoptosis via the downregulation of ERK/JNK/AKT signaling pathways.

Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine

2007 ◽  
Vol 45 (6) ◽  
pp. 935-944 ◽  
Author(s):  
Jiunn-Chang Lin ◽  
Yuan-Soon Ho ◽  
Jie-Jen Lee ◽  
Chien-Liang Liu ◽  
Tsen-Long Yang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Cycle Arrest ◽  
Induction Of Apoptosis ◽  
Human Colon Cancer Cells
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