Clinical significance of long noncoding RNA VIM‐AS1 and CTBP1‐AS2 expression in type 2 diabetes

2018 ◽  
Vol 120 (6) ◽  
pp. 9315-9323 ◽  
Author(s):  
Maryam Erfanian Omidvar ◽  
Hamid Ghaedi ◽  
Faranak Kazerouni ◽  
Saeid kalbasi ◽  
Mehrnoosh Shanaki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Significance ◽  
Long Noncoding Rna ◽  
Noncoding Rna

Genetic variants in long noncoding RNA H19 and MEG3 confer risk of type 2 diabetes in an Iranian population

Gene ◽  
2018 ◽  
Vol 675 ◽  
pp. 265-271 ◽  
Author(s):  
Hamid Ghaedi ◽  
Ali Zare ◽  
Mir Davood Omrani ◽  
Amir Hossein Doustimotlagh ◽  
Reza Meshkani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Iranian Population

Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus

2019 ◽  
Vol 79 (7) ◽  
pp. 519-523 ◽  
Author(s):  
Mahroo Mohamadi ◽  
Hamid Ghaedi ◽  
Faranak Kazerouni ◽  
Maryam Erfanian Omidvar ◽  
Saeid Kalbasi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus

BBA Clinical ◽  
2015 ◽  
Vol 4 ◽  
pp. 102-107 ◽  
Author(s):  
Gay Carter ◽  
Branko Miladinovic ◽  
Achintya A. Patel ◽  
Lauren Deland ◽  
Stephen Mastorides ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Long Noncoding Rna ◽  
Noncoding Rna

Inhibition of long noncoding RNA IGF2AS promotes angiogenesis in type 2 diabetes

2017 ◽  
Vol 92 ◽  
pp. 445-450 ◽  
Author(s):  
Zhuo Zhao ◽  
Bin Liu ◽  
Bo Li ◽  
Chunli Song ◽  
Hongying Diao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Markers of endothelial dysfunction in men with type 2 diabetes and their clinical significance

2016 ◽  
Vol 0 (3) ◽  
Author(s):  
Irina Khripun ◽  
Elizaveta Dzantieva ◽  
Sergey Vorobyev ◽  
Zalina Gusova ◽  
Maksim Morgunov ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Endothelial Dysfunction ◽  
Clinical Significance

scholarly journals Clinical Significance of the Maximum Body Mass Index Before Onset of Type 2 Diabetes for Predicting Beta-Cell Function

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Harutoshi Ozawa ◽  
Kenji Fukui ◽  
Sho Komukai ◽  
Yoshiya Hosokawa ◽  
Yukari Fujita ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Insulin Secretion ◽  
Beta Cell ◽  
Clinical Significance ◽  
Beta Cell Function ◽  
Cell Function ◽  
Duration Of Diabetes ◽  
Maximum Body

Abstract Objective This study aimed to clarify the clinical significance of the maximum body mass index (BMI) before the onset of type 2 diabetes (MBBO) for predicting pancreatic beta-cell function. Methods This was a cross-sectional observational study. Of 1304 consecutively admitted patients with type 2 diabetes, we enrolled 410 patients satisfying the criteria in this study. The correlations between the C-peptide index (CPI), which is one of the parameters that reflects beta-cell function, and various clinical parameters, including MBBO and duration of diabetes, were analyzed in multiple linear regression analyses. Results The analyses revealed that MBBO was correlated with CPI independently after adjustment for age, sex, HbA1c, and duration of diabetes. When we divided the subjects into three subgroups by MBBO (MBBO < 25 kg/m2; 25 kg/m2 ≤ MBBO < 30 kg/m2; MBBO ≥ 30 kg/m2), CPI was negatively correlated with duration of diabetes in each subgroup, while the rates of CPI based on the duration of diabetes were not different among the three MBBO subgroups. In contrast, the declining rates of CPI were higher in the BMI ≥ 25 kg/m2 group on admission than in the BMI < 25 kg/m2 group on admission. Conclusions MBBO may be an independent factor correlating with beta-cell function and may predict insulin secretion capacity at diagnosis, but it does not seem to affect the rate of decline in insulin secretion capacity after diagnosis. It is important to preserve beta-cell function by decreasing a patient’s BMI during treatment after diagnosis regardless of MBBO.

Sign in / Sign up

Export Citation Format

Share Document