Promoting osteogenic differentiation of human‐induced pluripotent stem cells by releasing Wnt/β‐catenin signaling activator from the nanofibers

2018 ◽  
Vol 120 (4) ◽  
pp. 6339-6346 ◽  
Author(s):  
Fatemeh Sadat Hosseini ◽  
Fatemeh Soleimanifar ◽  
Arash Khojasteh ◽  
Abdolreza Ardeshirylajimi
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Osteogenic Differentiation ◽  
Pluripotent Stem Cells ◽  
Induced Pluripotent

scholarly journals Dysregulation of Mitochondrial Functions and Osteogenic Differentiation in Cisd2-Deficient Murine Induced Pluripotent Stem Cells

2015 ◽  
Vol 24 (21) ◽  
pp. 2561-2576 ◽  
Author(s):  
Ping-Hsing Tsai ◽  
Yueh Chien ◽  
Jen-Hua Chuang ◽  
Shih-Jie Chou ◽  
Chian-Hsu Chien ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Osteogenic Differentiation ◽  
Pluripotent Stem Cells ◽  
Mitochondrial Functions ◽  
Induced Pluripotent

scholarly journals Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells

2014 ◽  
Vol 10 (12) ◽  
pp. 4961-4970 ◽  
Author(s):  
Heemin Kang ◽  
Yu-Ru V. Shih ◽  
Yongsung Hwang ◽  
Cai Wen ◽  
Vikram Rao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Osteogenic Differentiation ◽  
Pluripotent Stem Cells ◽  
Induced Pluripotent

Resveratrol Promotes Osteogenic Differentiation and Protects Against Dexamethasone Damage in Murine Induced Pluripotent Stem Cells

2010 ◽  
Vol 19 (2) ◽  
pp. 247-258 ◽  
Author(s):  
Chung-Lan Kao ◽  
Lung-Kuo Tai ◽  
Shih-Hwa Chiou ◽  
Yi-Jen Chen ◽  
Kung-Hsiung Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Osteogenic Differentiation ◽  
Pluripotent Stem Cells ◽  
Induced Pluripotent

Concise review; the recent methods that enhance the osteogenic differentiation of human induced pluripotent stem cells

2021 ◽  
Vol 16 ◽  
Author(s):  
Yongchun Hou ◽  
Zi Yan ◽  
Zhongqi Wu
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Induced Pluripotent Stem Cells ◽  
Osteogenic Differentiation ◽  
Pluripotent Stem Cells ◽  
Bone Defects ◽  
Rapid Expansion ◽  
Differentiation Potential ◽  
Skeletal Defects ◽  
Induced Pluripotent

Bone regeneration is a critical problem in modern clinical practice. Osteocytes are the most abundant cell population of mature adult bone that plays major roles in the regulation of bone formation. In humans, the segmental bone defects cannot be repaired by endogenous regenerative mechanisms. Bone tissue engineering (BTE) is a promising option for the treatment of difficult segmental and skeletal defects. BTE requires suitable cell sources with rapid expansion and adequate function, inducible factors, and scaffolds, to successfully regenerate or repair the bone injury. To overcome the disadvantages of using allogeneic and autologous tissue grafts, stem cell-based therapy has progressed an advanced topic in regenerative medicine. In the past few decades, numerous attempts have been made to generate osteocytes by using pluripotent stem cells (PSCs) for repair and regeneration of bone defects. Human induced pluripotent stem cells (hiPSCs) are PSCs that can self-renew and differentiate into a variety of cell types. Reprogramming of human somatic cells into hiPSCs provides a new opportunity for regenerative medicine, cell-based drug discovery, disease modeling, and toxicity assessment. The ability to differentiate hiPSCs towards mesenchymal stem cells (iPSC-MSCs) is essential for treating bone-related damages and injuries. Several in vitro studies revealed that the cell type of origin for iPSCs, a combination of transcription factors, the type of promoter in the vector, transduction methods, scaffolds, differentiating techniques, and culture medium may affect the osteogenic differentiation potential of hiPSCs. This review will focus on several factors that influence the osteogenic differentiation of human iPSCs.

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